Rchr
J-GLOBAL ID：200901029698863761
Update date: Oct. 15, 2024
Inoue Ryuji
イノウエ リュウジ | Inoue Ryuji
Affiliation and department：
Job title：
Specially Appointed Research Professor
Homepage URL (1)：
http://www.med.fukuoka-u.ac.jp/physiol/
Research field (2)：
Physiology
, Pharmacology
Research keywords (6)：
model simulation
, muscle physiology
, molecular biology
, voltage-dependent Ca channel
, TRP channel superfamily
, voltage- and receptor-operated Ca mobilization
Research theme for competitive and other funds (27)：
- 2020 - 2023 Numerical analyses of the complex pathogenesis for hereditary tachy-/brady-arrhythmias due to TRPM4 channel mutations
- 2015 - 2019 Multi-hierarchical analysis of the role of TRPM4 subfamily members in cardiac atrial arrhythmogenicity
- 2014 - 2017 Lipid regulation on receptor-operated ion channels and its tuning by Ca2+
- 2012 - 2016 Exploration of the mechanisms underlying normal glomerular filtration function and its pathologic disruption via the TRPC6-slit diaphragm protein complex-mediated mechano-signaling
- 2010 - 2016 Establishment of Integrative Multi-level Systems Biology and its Applications
- 2012 - 2015 Development of innovative treatments for epilepsy based upon its molecular pathomechanisms using patient iPS cells and novel genetically engineered animals.
- 2010 - 2015 Integrative study on arrhythmogenicity associated with adaptive and pathological remodeling of stressed hearts.
- 2010 - 2014 PIPs and Ca2+-dependent regulation on Ca channels
- 2009 - 2011 パーキンソン病発症機転における受容体活性化CaチャネルTRPC6蛋白質の役割解明
- 2009 - 2011 Development of genetically engineered animal models and novel therapeutic measures for human Epilepsy
- 2009 - 2011 On the mechanism of modal regulation of cardiovascular Ca2+entry channel TRPC6
- 2008 - 2010 Regulatory mechanisms of Ca^<2+> oscillations and transcription factor NFAT in osteoclastogenesis.
- 2005 - 2006 Molecular elucidation of CaMKII-mediated regulation of vascular receptor-operated Ca^<2+> entry channel TRPC6.
- 2005 - 2006 Pharmacological study on the mechano-sensitive molecules involved in vascular smooth muscle and endothelial cells.
- 2003 - 2004 Role of transient receptor potential protein 7(TRP7), receptor-activated Ca^<2+> channels, in myocardial apoptosis
- 2002 - 2004 cDNA cloning of the new nigedipine-insenstive voltage-dependent Ca^2+ channels in the peripheral resistant artery..
- 2002 - 2003 Development of TRPC6 channel specific inhibitor as a new prototypic anti-hypertensive drug.
- 2000 - 2001 Molecular elucidation of receptor-operated Ca^<2+> permeable cation channels with TRP as candidate proteins
- 2000 - 2001 Elucidation of roles and development of selective blockers for novel voltage-gated Ca2+ channels in peripheral resistant arterioles
- 1999 - 1999 末梢循環調節における新型電位依存性Ca^<2+>チャネルの役割の解明
- 1998 - 1999 Investigation on regulatory mechanisms for smooth muscle receptor-operated Ca^<2+> permeable cation channels using lipid bilayer incorporation of plasma membrane vesicles.
- 1998 - 1999 Specific interaction of FK506 binding protein (FKBP) isoforms with the ryanodine/CaィイD12+ィエD1 release channel subtypes
- 1996 - 1997 Pharmacological studies on the NO-dependent and -independent NANC neurotransmitters in the human and cat airway.
- 1996 - 1996 平滑筋の受容体作動性陽イオンチャネルを介したCa動員に及ぼす機械刺激の効果
- 1995 - 1995 平滑筋における受容体作動性Ca透過型陽イオンチャネルのリン酸化による制御機構
- 1994 - 1995 Pharmacological studies on the active factors derived from airway epithelial cells.
- 1994 - 1994 受容体作動性陽イオン電流と細胞内Ca貯蔵部位の平滑筋収縮における相互連関
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Papers (174)：
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Reiko Sakaguchi, Nobuaki Takahashi, Takashi Yoshida, Nozomi Ogawa, Yoshifumi Ueda, Satoshi Hamano, Kaori Yamaguchi, Seishiro Sawamura, Shinichiro Yamamoto, Yuji Hara, et al. Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals. Journal of Biological Chemistry. 2024. 300. 9. 107705-107705
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Yaopeng Hu, Jiehui Cang, Keizo Hiraishi, Takayuki Fujita, Ryuji Inoue. The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis. International Journal of Molecular Sciences. 2023. 24. 14. 11798-11798
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Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, et al. Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation. Scientific Reports. 2022. 12. 1
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Keizo Hiraishi, Lin Hai Kurahara, Kaori Ishikawa, Tetsuhiko Go, Naoya Yokota, Yaopeng Hu, Takayuki Fujita, Ryuji Inoue, Katsuya Hirano. Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2022. 58. 50-62
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Yaopeng Hu, Qin Li, Yanghua Shen, Takayuki Fujita, Xin Zhu, Ryuji Inoue. Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block. International Journal of Molecular Sciences. 2021. 22. 16. 8513-8513
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MISC (72)：
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李 欽, 朱 欣, 胡 耀鵬, 沈 文楓, 井上 隆司. 過剰なTRPM4チャネルの活性が伝導速度とAP形状に変化を及ぼす可能性の検討 コンピュータシミュレーション研究(Excessive TRPM4 channel activity may change conduction velocities and AP shapes: a computer simulation study). 心電図. 2020. 40. Suppl.2. S-52
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Keizo Hiraishi, Lin-Hai Kurahara, Yuanyuan Cui, Ryuji Inoue. Pathophysiological Contribution of TRPM7 Channel to Pulmonary Arterial Hypertension. BIOPHYSICAL JOURNAL. 2020. 118. 3. 414A-414A
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胡耀鵬, 平石敬三, 倉原琳, 沼田朋大, 井上隆司. 徐脈性不整脈遺伝子変異TRPM4-E7Kチャネルの数理モデルシミュレーション. 日本生理学雑誌(Web). 2019. 81. 1
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小松 志保, 野見山 崇, 沼田 朋大, 堀川 剛, 川波 賢子, 濱口 百合子, 高橋 貴理子, 岩屋 智加予, 田中 智子, 井上 隆司, et al. がん SGLT2阻害薬イプラグリフロジンは乳癌細胞増殖を抑制する. 糖尿病合併症. 2018. 32. Suppl.1. 224-224
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小松 志保, 野見山 崇, 沼田 朋大, 岩屋 智加予, 川波 賢子, 濱口 百合子, 田中 智子, 田邉 真紀人, 井上 隆司, 柳瀬 敏彦. SGLT2阻害薬イプラグリフロジンは乳癌細胞増殖を抑制する. 糖尿病. 2018. 61. 4. 291-291
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Books (13)：
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New Insights into Inflammatory Bowel Disease
InTechOpen 2016 ISBN:9789535127543
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The pathophysiological implications of TRP channels in cardiac arrhythmia
InTech 2012 ISBN:9789535101260
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Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation.
Springer Verlag, Germany 2012 ISBN:9789400750722
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TRP channels and blood pressure regulation. In; TRP Channels in Health and Disease: Implication for Diagnosis and Therapy
Nova Science Publishers 2011
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電位非依存性Caチャネル群の分子実体としてのTRP蛋白質ファミリー In: 脳機能の解明-生命科学の主潮流-
編者、赤池 紀扶他、ガイア出版。 2002
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Lectures and oral presentations (90)：
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2D-simulation analysis of conduction failure caused by a gain-of-function mutation of TRPM4 channel.
(The 98th Annual Meeting of the Physiological Society of Japan 2021)
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From receptor-operated Ca2+ channels to TRP channels -my personal challenge to understanding elusive but fascinating molecules-.
(NIPS International Meeting on Cardiovascular Physiology 2020. HOLISTIC UNDERSTANDING OF CARDIOVASCULAR SYSTEM BY MECHANISTIC ANALYSIS OF PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. 2020)
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An updated overview on TRP channels involved in cardiovascular inflammatory/fibroproliferative diseases.
(The 97th Annual Meeting of the Physiological Society of Japan 2020)
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Diversity of Ca2+entry mechanisms associated with vascular functions
(The 97th Annual Meeting of the Physiological Society of Japan 2020)
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Numerical model-based studies on the activation/regulation of TRP channels.
(Frontiers in Biomedical Science Seminar 2019)
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Education (3)：
- 1983 - 1987 Kyushu University Graduate School of Medical Sciences
- 1977 - 1981 Osaka University Faculty of Medicine 医学科
- 1973 - 1977 The University of Tokyo The Faculty of Engineering Urban Designing
Professional career (1)：
- D.Med.Sci.(PhD.) (Kyushu University)
Work history (5)：
- 2020/04 - 現在 Fukuoka University Faculty of Medicine School of Medicine, Division for the Promotion of Sciences Specially Appointed Research Professor, Professor Emeritus
- 2005/04 - 2020/03 Fukuoka University Faculty of Medicine School of Medicine professor
- 1995 - 2005 九州大学大学院医学研究院生体情報薬理学・助教授
- 1989/03 - 1991/02 University of Oxford Department of Pharmacology postdoctoral fellow
- 1987/06 - 1989/02 Institute for Physiology, University of Cologne, West Germany Fellow, Humboldt Foundation (West Germany)
Committee career (1)：
- 2010/10 - 2017/08 IUPS Commission II chair
Awards (2)：
- 2001 - 日本心脈管作動物質学会奨励賞
- 1994 - Young Investigator's award (Japanese Pharmacological Society)
Association Membership(s) (3)：
日本循環薬理学会
, Japanese Smooth Muscle Research Society
, 日本生理学会
