Rchr
J-GLOBAL ID：200901029698863761
Update date: Jul. 28, 2022
Inoue Ryuji
イノウエ リュウジ | Inoue Ryuji
Affiliation and department：
Job title：
Specially Appointed Research Professor
Homepage URL (1)：
http://www.med.fukuoka-u.ac.jp/physiol/
Research field (2)：
Physiology
, Pharmacology
Research keywords (6)：
model simulation
, muscle physiology
, molecular biology
, voltage-dependent Ca channel
, TRP channel superfamily
, voltage- and receptor-operated Ca mobilization
Research theme for competitive and other funds (26)：
- 2020 - 2023 Numerical analyses of the complex pathogenesis for hereditary tachy-/brady-arrhythmias due to TRPM4 channel mutations
- 2015 - 2019 Multi-hierarchical analysis of the role of TRPM4 subfamily members in cardiac atrial arrhythmogenicity
- 2014 - 2017 Lipid regulation on receptor-operated ion channels and its tuning by Ca2+
- 2012 - 2016 Exploration of the mechanisms underlying normal glomerular filtration function and its pathologic disruption via the TRPC6-slit diaphragm protein complex-mediated mechano-signaling
- 2010 - 2016 Establishment of Integrative Multi-level Systems Biology and its Applications
- 2012 - 2015 Development of innovative treatments for epilepsy based upon its molecular pathomechanisms using patient iPS cells and novel genetically engineered animals.
- 2010 - 2015 Integrative study on arrhythmogenicity associated with adaptive and pathological remodeling of stressed hearts.
- 2010 - 2014 PIPs and Ca2+-dependent regulation on Ca channels
- 2009 - 2011 Development of genetically engineered animal models and novel therapeutic measures for human Epilepsy
- 2009 - 2011 On the mechanism of modal regulation of cardiovascular Ca2+entry channel TRPC6
- 2008 - 2010 Regulatory mechanisms of Ca^<2+> oscillations and transcription factor NFAT in osteoclastogenesis.
- 2005 - 2006 Molecular elucidation of CaMKII-mediated regulation of vascular receptor-operated Ca^<2+> entry channel TRPC6.
- 2005 - 2006 Pharmacological study on the mechano-sensitive molecules involved in vascular smooth muscle and endothelial cells.
- 2003 - 2004 Role of transient receptor potential protein 7(TRP7), receptor-activated Ca^<2+> channels, in myocardial apoptosis
- 2002 - 2004 cDNA cloning of the new nigedipine-insenstive voltage-dependent Ca^2+ channels in the peripheral resistant artery..
- 2002 - 2003 Development of TRPC6 channel specific inhibitor as a new prototypic anti-hypertensive drug.
- 2000 - 2001 Molecular elucidation of receptor-operated Ca^<2+> permeable cation channels with TRP as candidate proteins
- 2000 - 2001 Elucidation of roles and development of selective blockers for novel voltage-gated Ca2+ channels in peripheral resistant arterioles
- 1999 - 1999 末梢循環調節における新型電位依存性Ca^<2+>チャネルの役割の解明
- 1998 - 1999 Investigation on regulatory mechanisms for smooth muscle receptor-operated Ca^<2+> permeable cation channels using lipid bilayer incorporation of plasma membrane vesicles.
- 1998 - 1999 Specific interaction of FK506 binding protein (FKBP) isoforms with the ryanodine/CaィイD12+ィエD1 release channel subtypes
- 1996 - 1997 Pharmacological studies on the NO-dependent and -independent NANC neurotransmitters in the human and cat airway.
- 1996 - 1996 平滑筋の受容体作動性陽イオンチャネルを介したCa動員に及ぼす機械刺激の効果
- 1995 - 1995 平滑筋における受容体作動性Ca透過型陽イオンチャネルのリン酸化による制御機構
- 1994 - 1995 Pharmacological studies on the active factors derived from airway epithelial cells.
- 1994 - 1994 受容体作動性陽イオン電流と細胞内Ca貯蔵部位の平滑筋収縮における相互連関
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Papers (166)：
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Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, et al. Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation. Scientific Reports. 2022. 12. 1
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Yaopeng Hu, Qin Li, Yanghua Shen, Takayuki Fujita, Xin Zhu, Ryuji Inoue. Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block. International Journal of Molecular Sciences. 2021. 22. 16. 8513-8513
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Keizo Hiraishi, Lin Hai Kurahara, Jianlin Feng, Aya Yamamura, Yuanyuan Cui, Eiji Yahiro, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Naoya Yokota, et al. Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Translational Research. 2021. 233. 127-143
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Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue. An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP2 Interaction. Cells. 2021. 10. 5. 983-983
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Shohei Yoshimoto, Miho Matsuda, Kenichi Kato, Eijiro Jimi, Hiroshi Takeuchi, Shuji Nakano, Shunichi Kajioka, Etsuko Matsuzaki, Takao Hirofuji, Ryuji Inoue, et al. Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells. European Journal of Pharmacology. 2021. 895. 173881-173881
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MISC (54)：
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井上 隆司, 菅 忠, 瓦林 靖広, 本田 啓. O-29.PKGリン酸化による血管受容体作動性Ca^<2+>チャネルTRPC6チャネルの活性化モード転換機構(血管3,一般口演,一般演題,第51回日本平滑筋学会総会). 日本平滑筋学会雑誌. 2009. 13. 1. "J-17"
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Kinoshita Hideyuki, Kuwahara Koichiro, Inoue Ryuji, Nishida Motohiro, Kurose Hitoshi, Kiyonaka Shigeki, Mori Yasuo, Li Yuhao, Rong Xiang Lu, Murakami Masao, et al. DPE-007 Protein Kinase G-mediated Inhibition of TRPC6 Channel Activity Participates in Anti-hypertrophic Effect of Cardiac Natriuretic Peptides(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society). Circulation journal : official journal of the Japanese Circulation Society. 2009. 73. 357-357
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Kinue Nishioka, Marina Ariyoshi, Ryuji Inoue, Michio Nakaya, Motohiro Nishida, Hitoshi Kurose. INVOLVEMENT OF TRANDIENT RECEPTOR POTENTIAL (TRP) CHANNELS IN VASODILATION BY CILOSTAZOL. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009. 59. 409-409
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Kinue Nishioka, Marina Ariyoshil, Ryuji Inoue, Michio Nakaya, Motohiro Nishida, Hitoshi Kurose. Vasodilating effect of cilostazol through inhibition of TRPC channels. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 140P-140P
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New frontier for the pathophysiology of TRP channels in cardiovascular system: cardiovascular remodeling and TRP channels. Protein, nucleic acid and enzyme. 2008. 53. 7. 844-853
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Books (13)：
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New Insights into Inflammatory Bowel Disease
InTechOpen 2016 ISBN:9789535127543
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The pathophysiological implications of TRP channels in cardiac arrhythmia
InTech 2012 ISBN:9789535101260
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Lipid-mediated mechanisms involved in the mechanical activation of TRPC6 and TRPV4 channels in the vascular tone regulation.
Springer Verlag, Germany 2012 ISBN:9789400750722
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TRP channels and blood pressure regulation. In; TRP Channels in Health and Disease: Implication for Diagnosis and Therapy
Nova Science Publishers 2011
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電位非依存性Caチャネル群の分子実体としてのTRP蛋白質ファミリー In: 脳機能の解明-生命科学の主潮流-
編者、赤池 紀扶他、ガイア出版。 2002
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Lectures and oral presentations (90)：
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2D-simulation analysis of conduction failure caused by a gain-of-function mutation of TRPM4 channel.
(The 98th Annual Meeting of the Physiological Society of Japan 2021)
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From receptor-operated Ca2+ channels to TRP channels -my personal challenge to understanding elusive but fascinating molecules-.
(NIPS International Meeting on Cardiovascular Physiology 2020. HOLISTIC UNDERSTANDING OF CARDIOVASCULAR SYSTEM BY MECHANISTIC ANALYSIS OF PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. 2020)
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An updated overview on TRP channels involved in cardiovascular inflammatory/fibroproliferative diseases.
(The 97th Annual Meeting of the Physiological Society of Japan 2020)
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Diversity of Ca2+entry mechanisms associated with vascular functions
(The 97th Annual Meeting of the Physiological Society of Japan 2020)
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Numerical model-based studies on the activation/regulation of TRP channels.
(Frontiers in Biomedical Science Seminar 2019)
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Education (3)：
- 1983 - 1987 Kyushu University
- 1977 - 1981 Osaka University 医学科
- 1973 - 1977 The University of Tokyo Urban Designing
Professional career (1)：
- D.Med.Sci.(PhD.) (Kyushu University)
Work history (5)：
- 2020/04 - 現在 Fukuoka University Faculty of Medicine School of Medicine, Division for the Promotion of Sciences Specially Appointed Research Professor, Professor Emeritus
- 2005/04 - 2020/03 Fukuoka University Faculty of Medicine School of Medicine professor
- 1995 - 2005 九州大学大学院医学研究院生体情報薬理学・助教授
- 1989/03 - 1991/02 University of Oxford Department of Pharmacology postdoctoral fellow
- 1987/06 - 1989/02 Institute for Physiology, University of Cologne, West Germany Fellow, Humboldt Foundation (West Germany)
Committee career (1)：
- 2010/10 - 2017/08 IUPS Commission II chair
Awards (2)：
- 2001 - 日本心脈管作動物質学会奨励賞
- 1994 - Young Investigator's award (Japanese Pharmacological Society)
Association Membership(s) (3)：
日本循環薬理学会
, Japanese Smooth Muscle Research Society
, 日本生理学会
