Rchr
J-GLOBAL ID:200901029777143383
Update date: Apr. 19, 2024
Sugimura Haruhiko
スギムラ ハルヒコ | Sugimura Haruhiko
Affiliation and department:
Job title:
Director
Homepage URL (1):
http://www.sasaki-institute.org
Research field (2):
Experimental pathology
, Human pathology
Research keywords (16):
immune and metabolic check point
, genome medicine
, FISH
, chromosomal instability
, lung cancer
, genetic polymorphism
, adductome
, DNA adduct
, gastric cancer
, 実験腫瘍学
, 分子疫学
, 腫瘍病理学
, 分子病理学
, Experimental Oncology
, Molecular Epidemiology
, Molecular Pathology
Research theme for competitive and other funds (47):
- 2023 - 2027 Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues
- 2022 - 2027 Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymes
- 2018 - 2021 LIX1L蛋白質発現癌細胞でのRNA翻訳伸長反応制御による標的治療薬開発研究
- 2016 - 2018 RNA modifications of human tumors
- 2014 - 2018 Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them
- 2017 - 2018 環境要因による発がん機構の解明と予防法の確立
- 2000 - 2018 病理組織を用いたFISHによるcopy number analysis
- 2000 - 2018 FISH-Chip analysis in FFPE tissue.
- 1995 - 2018 胃・大腸・肝・肺癌の遺伝的感受性
- 1995 - 2018 Genetic Predisposition to Gastric, Hepatic and Lung Cancer
- 1991 - 2018 消化器及び呼吸器腫瘍の分子病理
- 2014 - 2017 Synthetic studies of DNA adducts and its amidites for DNA adductome analysis.
- 2014 - 2016 Distribution of DNA adducts in human tissues and its pathological significance
- 2014 - 2016 Applied evaluation to development and the pathological observation of the microscope based optical tomogram
- 2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- 2012 - 2014 Pathological Significance of modified nucleic acid base in human tissue.
- 2011 - 2013 Aberrant activations of cellular kinases and exploration of novel targeted therapy in human solid cancers
- 2011 - 2012 Property investigation of circulating tumor cells, primary and metastatic cancer tissues by use of whole genome sequencing and application to laboratory testing
- 2010 - 2011 adductome analysis of human tissues
- 2009 - 2010 循環腫瘍細胞の統合型オミックス解析による生物学的性状、病態診断に関する研究
- 2008 - 2009 修復遺伝子多型・変異のCommon Cancerの遺伝的素因への影響
- 2006 - 2007 修復遺伝子多型の喫煙関連がんおよび多発がんリスクへの影響
- 2005 - 2006 Possible new complementation group of xeroderma pigmentosum
- 2005 - 2005 修復遺伝子機能差多型のがん分子疫学的研究
- 2004 - 2005 Comparative analysis of replication timing among human cancer cell lines using microarray
- 2003 - 2005 Molecular pathological study of individual predisposition to gastric cancer
- 2003 - 2004 AP-PCR-SSCPを用いた病態特異的な遺伝子多型の網羅的探索法の確立と応用
- 2000 - 2004 代謝酵素遺伝子多型に基づいた宿主環境相互作用と発癌感受性の研究
- 1998 - 2001 Genetic polymorphism and susceptibility of common cancer
- 1998 - 2000 Establishment of Renal Stone Formation Model in Cell Culture and Isolation Study of Genetic Calculogenesis Factors
- 1999 - 1999 中国江蘇省の胃・食道がんの高・低率地域における防御要因に関する比較疫学研究
- 1998 - 1998 日本人家族集積性胃癌の分離比分析(Segregationanalysis)と分子病理
- 1996 - 1998 COMPARATIVE STUDY ON RISK FACTORS FOR UPPER G-I TRACT CANCER IN CHINA
- 1997 - 1997 胃癌の遺伝子不安定と浸潤能多発例、家族集積例の分子病理学的検討
- 1997 - 1997 ブラジル在住日系人の発がんにおける食事・栄養素と遺伝素因に関する研究
- 1996 - 1997 Lung cancer susceptibility gene and molecular pathology of lung cancer.
- 1996 - 1996 Diet, genetic factor and cancer in Japanese Brazilian
- 1993 - 1995 Innovation of the diagnosis and the treatment of colorectal cancer utilizing the cancer related gene analysis.
- 1995 - エフ/エフリンの病態的意義
- 1994 - 1994 症例対照研究を用いた癌感受性遺伝子の評価
- 1994 - 1994 消化管癌-胎児性遺伝子の単離と組織診断への適用
- 1994 - 1994 日本人肉腫の病理疫学的研究
- 1993 - 1993 日本人肉腫の病理疫学的研究
- 1991 - 1993 Molecular-Pathological investigation of human thyroid cancer with a special focus on poorly differentiated carcinoma
- 1992 - 1992 日本人肉腫の病理疫学的研究
- Eph/Ephrin in Pathology
- Molecular Pathology of Digestive and Respiratory Organ Tumor
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Papers (260):
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De Hu, Hidetaka Yamada, Katsuhiro Yoshimura, Tsutomu Ohta, Kazuo Tsuchiya, Yusuke Inoue, Kazuhito Funai, Takafumi Suda, Yuji Iwashita, Takuya Watanabe, et al. High Expression of Fas-Associated Factor 1 Indicates a Poor Prognosis in Non-Small-Cell Lung Cancer. Current oncology (Toronto, Ont.). 2023. 30. 11. 9484-9500
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金子 雅直, 中島 光子, 杉浦 喜一, 石田 夏樹, 田村 智, 谷 伸也, 山出 美穂子, 濱屋 寧, 大澤 恵, 立田 協太, et al. 大腸髄様癌はMLH1欠損かつBRAFV600E変異陽性の特徴を有する. 日本消化器病学会雑誌. 2023. 120. 臨増大会. A801-A801
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Masanao Kaneko, Mitsuko Nakashima, Kiichi Sugiura, Natsuki Ishida, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Kyota Tatsuta, et al. Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study. Medicine. 2023. 102. 38. e35022
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Naotaka Izuo, Hajime Miyanishi, Daisuke Nishizawa, Takuma Fujii, Junko Hasegawa, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Atsumi Nitta. DNA methylation status of SHATI/NAT8L promoter in the blood of cigarette smokers. Neuropsychopharmacology Reports. 2023
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Shin-Ya Katsuragi, Yoshiro Otsuki, Shuhei Unno, Masaharu Kimata, Yashiro Yoshizawa, Makoto Tomatsu, Kazuya Shinmura, Kazufumi Suzuki, Haruhiko Sugimura. Evaluation of the widths of the mucosal strips in pathological examination of specimens of endoscopic submucosal dissection for early gastric cancer. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2023. 26. 5. 755-762
more...
MISC (790):
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金子雅直, 中島光子, 杉浦喜一, 石田夏樹, 田村智, 谷伸也, 山出美穂子, 濱屋寧, 大澤恵, 立田協太, et al. 大腸髄様癌はMLH1欠損かつBRAFV600E変異陽性の特徴を有する. 日本消化器病学会雑誌(Web). 2023. 120
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FELIX Manirakiza, 山田英孝, 岩下雄二, 石野佳子, TAO Hong, 椙村春彦. Novel TP53 frameshift mutations in Romanian colorectal cancers. 大腸癌研究会プログラム・抄録集. 2022. 96th
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奥田亜弥, 橋本志野, 田村和朗, 田村和朗, 小嶋志之, 山田英孝, 岩泉守哉, 椙村春彦. 遺伝性びまん性胃がん(Hereditary Diffuse Gastric Cancer:HDGC)の1例. 日本遺伝性腫瘍学会学術集会プログラム・抄録集. 2022. 28th
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椙村春彦, 山田英孝. 本邦の遺伝性胃癌の探索の現状. 日本遺伝性腫瘍学会学術集会プログラム・抄録集. 2022. 28th
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川端 弥生, 五十嵐 久喜, 椙村 春彦. 接合菌類(ムコール菌)同定を目的としたグロコット染色 熱処理および過ヨウ素酸による酸化についての検討. 医学検査. 2022. 71. 1. 53-60
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Patents (13):
Books (3):
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ライフサイエンス 顕微鏡学ハンドブック
朝倉書店 2017
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Cancer and Inflammation Mechanisms
Wiley 2014
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Tumors of the central nervous system
Springer Science+Business Media 2011
Lectures and oral presentations (7):
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質量分析によるDNA付加体の網羅的同定法の開発
(2018 がん予防学術大会 2018)
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Identification of gastric cancer-related DNA adducts by DNA adductome analysis
(2017 EMGS Annual Meeting, Raleigh, NC 2017)
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Individual susceptibility of gastric cancer, a perspective from molecular epidemiology
(89th Annual Meeting of the Japanese Gastric Cancer Association 2017)
-
Updates of immunotherapyof lung cancer
(International conference of update of cancer prevention and research, Lucknow, India 2017)
-
日本の遺伝性胃がんの現状
(日本癌学会 2016)
more...
Education (2):
- 1982 - 1986 The University of Tokyo
- 1976 - 1982 The University of Tokyo Faculty of Medicine
Professional career (1):
Work history (9):
- 2023/06 - 現在 National University Corporation Hamamatsu University School of Medicine Professor Emeritus
- 2022/05 - 現在 Sasaki Institute, Sasaki Foundation Director
- 1995/11 - 2023/03 Hamamatsu University School of Medicine The First Department of Pathology (Department of Tumor Pathology) Professor
- 2020/04 - 2022/03 Hamamatsu University School of Medicine
- 1991/03 - 1995/11 Hamamatsu University School of Medicine The First Department of Pathology
- 1988/04 - 1991/02 The University of Tokyo Faculty of Medicine
- 1988/09 - 1990/08 National Cancer Institute, National Institute of Health Laboratory of Human Carcinogenesis Visiting Fellow
- 1987/05 - 1988/03 National Cancer Center Research Institute, Tokyo Epidemology Division Research Resident
- 1986/04 - 1986/05 Tokyo University Hospital Faculty of Medicine University Hospital Department of Pathology
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Committee career (10):
- 2019/04 - 現在 The Japanese Society of Hereditary Tumors Counciler
- 2017/10 - 現在 日本家族性腫瘍学会 家族性腫瘍専門医
- 2017/01 - 現在 日本胃癌学会 代議員
- 2016/01 - 現在 日本胃癌学会 胃癌取り扱い規約 委員 15版
- 2017 - 2019/06 日本がん疫学・分子疫学研究会 代表幹事
- 2016 - 2017 独立行政法人医薬品医療機器総合機構 (PMDA) 第二期科学委員会非臨床試験の活用に関する専門部会 委員
- 2001 - 日本癌学会 評議員
- 1999 - 日本がん分子疫学研究会 編集幹事
- 1992 - American Association for Cancer Research Active Member
- 1992 - 日本病理学会 学術評議員
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Awards (1):
- 2015/04 - 日本病理学会 日本病理学賞 ヒトがんの個体感受性
Association Membership(s) (8):
日本遺伝性腫瘍学会
, 日本胃癌学会
, 日本がん疫学・分子疫学研究会
, 日本消化器病学会
, American Association for Cancer Research
, 日本癌学会
, 日本肝臓学会
, 日本病理学会
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