Sugiyama Tsuyoshi

スギヤマツヨシ | Sugiyama Tsuyoshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.u-gifu-ms.ac.jp/

Research field (4)： Immunology , Bacteriology , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (7)： Intestinal bacterial flora , 自然免疫 , エンドトキシン , Toll様受容体 , innate immunity , endotoxin , Toll-like receptor

Research theme for competitive and other funds (8)：

2020 - 2023 Establishment of intestinal flora modification method for prevention of enterohemorrhagic Escherichia coli infection and inflammatory enteritis
2016 - 2020 Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant development
2009 - 2010 コッホの原則を満たす実験的マウス潰瘍性大腸炎起炎菌の同定
2004 - 2005 Inhibitory mechanism and the target of Toll like receptor signaling inhibitors
2001 - 2002 低濃度LPSに反応するB-1細胞のCD14を介したシグナル伝達経路の解析

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Papers (108)：

Shun Nakano, Masashi Nishikawa, Tomoyo Kobayashi, Eka Wahyuni Harlin, Takuya Ito, Katsuya Sato, Tsuyoshi Sugiyama, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda. The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN. The Journal of biological chemistry. 2022. 298. 2. 101579-101579
Keita Takahashi, Tsuyoshi Sugiyama, Nagisa Tokunoh, Shun Tsurumi, Tetsuo Koshizuka, Naoki Inoue. Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with Citrobacter rodentium. ImmunoHorizons. 2021. 5. 10. 870-883
Keiji NAGANO, Yutaka SHIRAK, Paola NERI, Yoshiharu MIYASHITA, Shunji TOKORO, Tsuyoshi SUGIYAMA, Hiroshi MORI. Cattle salivary IgA antibody titer against enterohemorrhagic Escherichia coli O157 as an indicator of harboring the bacterium. 2020. 2. 31-42
Naho Minegaki, Tetsuo Koshizuka, Saeka Nishina, Hiroki Kondo, Keita Takahashi, Tsuyoshi Sugiyama, Naoki Inoue. The Carboxyl-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Enhance Cell Proliferation. Biological & pharmaceutical bulletin. 2020. 43. 12. 1911-1916
Masashi Nishikawa, Shun Nakano, Hiromu Nakao, Katsuya Sato, Tsuyoshi Sugiyama, Yukihiro Akao, Hitoshi Nagaoka, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda. The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells. Cellular signalling. 2019. 61. 93-107

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MISC (27)：

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Books (1)：

Lectures and oral presentations (10)：

KIAA0599 augments TRIF- and Myd88-dependent TLR signaling
(Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society 2018)
Rhoグアニンヌクレオチド交換因子KIAA0362のToll様受容体シグナルへの影響
(第23回日本エンドトキシン・自然免疫研究会 2017)
組換えMajor royal jelly protein 3タンパク質の発現・精製および抗体の作製
(第8回岐阜薬科大学機能性健康食品研究講演会 2017)
A/E病変に伴うアクチンの重合が制御する宿主遺伝子発現
(第21回腸管出血性大腸菌感染症研究会 2017)
糞便移植を用いたデキストラン硫酸ナトリウム誘発マウス潰瘍性大腸炎モデルにおける腸内細菌叢と病態の関係の解析
(第54回日本細菌学会中部支部総会 2017)

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Professional career (1)：

Work history (1)：

Awards (1)：

Association Membership(s) (6)：

日本薬学会 , 毒素シンポジウム , International Endotoxin and Innate Immunity Society , 日本免疫学会 , 日本生化学会 , 日本細菌学会

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