Rchr

J-GLOBAL ID：200901029814222787 Update date: Nov. 14, 2024

Sasaki Ryohei

ササキリョウヘイ | Sasaki Ryohei

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.med.kobe-u.ac.jp/radonc/

Research field (1)： Radiology

Research keywords (6)： Particle therapy , Exosome , Medical device , Oncology , Radiation biology , Radiation oncology

Research theme for competitive and other funds (69)：

2024 - 2027 局所進行直腸癌のナノ粒子を用いた術前放射線免疫療法のモデル構築とその応用
2023 - 2026 難治性局所進行乳がんに対する金属ナノ粒子併用・超高線量率放射線治療法の開発
2023 - 2026 放射線応答エクソソームによる直腸癌Total neoadjuvant therapy(TNT)の治療効果予測
2024 - 2025 吸収性スペーサーを用いた体内空間可変・定位放射線治療の実用化研究
2022 - 2025 Development of radiosensitized nanoparticles for all cancers using simple and innovative surface-modified DDS

2022 - 2025 Space-making radiotherapy using bioabsorbable spacer

2021 - 2024 Comprehensive analysis of radiation-response miRNA for cell-to-cell communication

2021 - 2024 Development of Helium Ion CT Image System for Particle Therapy

2021 - 2024 A Novel immunoradiotherapy using TiOxNPs and tumor-derived exosome

2020 - 2024 Novel radiosensitizer with inorganic nanoparticles and antibodies assembly

2020 - 2023 A novel immuno-radiotherapy using autologus T cell and pH-responsive capsule for delivery of inorganic nanoparticles

2020 - 2023 Development of new radiation therapy using ultra-high dose rate slit beam and metal nanoparticles

2020 - 2023 金属ナノ粒子を応用した新規・免疫放射線増感療法の開発

2020 - 2023 小児・AYA世代の骨軟部肉腫に対する吸収性スペーサー併用陽子線治療の確立

2020 - 2023 獣医療における過酸化チタンナノ粒子を用いた新規・高精度放射線増感療法の開発

2019 - 2022 Space making particle therapy for sarcoma and pediatric tumor

2019 - 2022 Usefulness of exosome-derived PDL1 in radiation therapy

2019 - 2022 Development of Theranostic particle beam therapy using titanium peroxide nanoparticles

2018 - 2021 Development of a novel radiosensitizer with inorganic nanoparticles

2018 - 2021 Development of a new radiosensitizer utilizing the cell specificity of exosomes

2017 - 2020 Transarterial infusion of metallic nanoparticles for radiation therapy enhancement

2016 - 2020 Elucidation of the hypoxic immune response and its application to multidisciplinary therapy

2016 - 2019 Investigation of titanium peroxide nanoparticles for cancer therapy application

2016 - 2019 Next-generation bioabsorbable spacer for miminum invasive radiotherapy

2016 - 2019 A novel strategy for radiosensitization using titanium peroxide nanoparticles

2015 - 2018 Ultrahigh dose-rate, "FLASH" irradiation minimizes the side-effects of radiotherapy

2015 - 2018 Efficacy of prophylactic functional foods for amelioration of radiation enteropathy and its metabolism

2017 - 先端医療機器の開発/高い安全性と更なる低侵襲化及び高難度治療を可能にする軟性内視鏡手術システムの研究開発

2013 - 2016 Development of radioprotective agents for the intestine in radiotherapy

2013 - 2016 synchrotoron micro beam irradiation for tumors and normar tissue

2013 - 2016 Space modulated radiotherapy using bio-absorbable spacer

2013 - 2016 Establishment of Image guided brachytherapy using newly developed high quality vaginal wall spacer

2013 - 2016 Investigation of titanium peroxide nanoparticles for cancer therapy application

2013 - 2016 Diagnostic value of tumor metabolites in metabolome analysis for glioma patients

2013 - 2016 A Novel strategy of radiosensitization using titan peroxide nanoparticles

2016 - (AMED)先端医療機器の開発/高い安全性と更なる低侵襲化及び高難度治療を可能にする軟性内視鏡手術システムの研究開発

2012 - 2015 Efficacy and tolerance of ultra high dose rate synchrotron irradiation

2015 - 吸収性スペーサーを用いた体内空間可変粒子線治療の有用性と安全性の検討/陽子線治療による吸水性スペーサーの有用性と安全性の検討

2012 - 2014 Not only angiogenesis but also inflammation participate in the pathophysiology of brain radiation necrosis

2011 - 2013 子宮がん患者の放射線治療衣の開発

2010 - 2013 Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy

2011 - 2013 Development of intra-abdominal space modulated radiotherapy

2011 - 2012 The development of the clothing for improving the quality of life for uterine cancer patients

2010 - 2012 Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy

2009 - 2012 Clinical trials for the establishment of standard radiation therapy methods and the selection of radiosensitive tumors in early cancer patients

2009 - 2011 Chemoradiotherapy targeting autophagy mechanism against pancreas cancer.

2009 - 2011 Study on enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid

2011 - オートファジーを標的とした膵癌に対する集学的な新規放射線化学療法の開発

2010 - 2010 Development of the garment wearing during receiving radiation treatment for the patients with breast or uterine cancer

2008 - 2010 Basic Comparison of Biological Effects between Protons and Carbon-Ions

2008 - 2010 Development of the garment wearing during receiving radiation treatment for the patients with breast or uterine cancer

2010 - 陽子線・炭素線の生物学的効果に関する基礎的比較・検討

2007 - 2008 Redox-moduIated functional foods for protection of radiation-induced gastrointestineal damage

2006 - 2008 Clinical trials for the establishment of standard radiation therapy methods for early cancers

2008 - 自殺における細胞内情報伝達の変化に関する分子遺伝学的研究

2008 - レドックスを利用した消化管に対する機能性放射線防護食品の開発

2005 - 2006 Research of significance of AKT for the radioresistant mechanisms in normal and malignant tissue

2005 - 2006 Research for serum markers of radiosensitivity from cancer patients

2005 - 2006 放射線感受性・分子標的としてのp53蛋白のミトコンドリアゲノム制御機能

2006 - 臨床検体プロテオーム解析による癌患者の放射線感受性マーカー探索

2006 - 良性・悪性組織におけるAKTを介した放射線抵抗性のメカニズムの解析

2006 - 放射線感受性・分子標的としてのp53蛋白のミトコンドリアゲノム制御機能

2003 - 2004 Research of Proton and Carbon ion bean irradiation and its diagnostic methods

2003 - 2004 Research of increase radiosensitivity targeting DNA repair mechanism in treatment-resistant cells

2002 - 2003 INNOVATION FOR TISSUE-SPECIFIC RADIO-SENCITIZATION OF SELECTIVE INHIBITOR OF CYCLO-OXYGENASE 2 (COX-2)

2002 - 2003 拡散強調MRI及びMRSによる遺伝子治療の生体内効果伴定法の開発

2001 - 2002 Estimation of Biologic and Molecular Aspects of Heavy Charged Particle Therapy for Cancer Cells

2000 - 2002 Efficacy of Combination Therapy of Ionizing Radiation and Gene Therapy in Prostate Cancer in vitro

1999 - 2001 Basic research for the development of electroporation-electrode-mounted balloon catheter

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Papers (381)：

Akihiro Fujisawa, Shohei Komatsu, Satoshi Omiya, Ryosuke Fujinaka, Nobuaki Yamasaki, Hiroaki Yanagimoto, Masahiro Kido, Hirochika Toyama, Ryohei Sasaki, Takumi Fukumoto. Evaluation of Interaction With Bio-absorbable Polyglycolic Acid Spacer and Anti-adhesive Agents Using a Rat Experimental Model. Anticancer research. 2024. 44. 8. 3349-3353
Toshiyuki Takemori, Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Ryoko Sawada, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Shunsuke Yahiro, et al. Comparison of clinical outcome between surgical treatment and particle beam therapy for pelvic bone sarcomas: A retrospective multicenter study in Japan. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2024
Mitsuko Yui, Yoshihisa Matsuno, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Naomi Kiyota, Tadashi Nomura, Daisuke Miyawaki, Ryohei Sasaki, Ken-Ichi Nibu. Oncological Outcomes of Concurrent Chemoradiotherapy and Surgical Treatment for Patients With T3 Hypopharyngeal Cancer: A Single-Center Retrospective Analysis. Cureus. 2024. 16. 6. e62553
大片祐一, 小松昇平, 出水祐介, 山本暢之, 佐々木良平, 福本巧, 尾藤祐子. 小児がん支持療法と関連する外科治療吸収性スペーサー留置術神戸大学における経験と小児領域への応用. 日本小児血液・がん学会雑誌. 2024. 60. 5. 297-300
Daisuke Kawahara, Yuji Murakami, Shota Awane, Yuki Emoto, Kazuma Iwashita, Hikaru Kubota, Ryohei Sasaki, Yasushi Nagata. Radiomics and dosiomics for predicting complete response to definitive chemoradiotherapy patients with oesophageal squamous cell cancer using the hybrid institution model. European radiology. 2024. 34. 2. 1200-1209

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MISC (312)：

出水祐介, 美馬正幸, 福光延吉, 鈴木毅, 畠山理, 小阪嘉之, 福本巧, 佐々木良平, 副島俊典. Space-making proton therapy using bioabsorbable spacer for a pediatric case with Ewing sarcoma: Upfront boost irradiation. 日本小児血液・がん学会雑誌(Web). 2021. 58. 4
岩下和真, 石原武明, 妹尾悟史, 窪田光, 川口弘毅, 小林加奈, 宮脇大輔, 佐々木良平, 蓼原瞬, 手島直則, et al. T3N0M0声門癌に対する根治的放射線治療の成績. 頭頸部癌. 2021. 47. 2
小山泰司, 清田尚臣, 清田尚臣, 今村善宣, 長谷善明, 蓼原瞬, 手島直則, 四宮弘隆, 宮脇大輔, 佐々木良平, et al. 再発・転移頭頸部扁平上皮癌に対するニボルマブ療法治療の予後予測における好酸球数変化の有用性. 頭頸部癌. 2021. 47. 2
Sachiko Inubushi, Hiroki Kawaguchi, Sachiko Mizumoto, Tomonari Kunihisa, Motoi Baba, Yukiya Kitayama, Toshifumi Takeuchi, Robert M. Hoffman, Hirokazu Tanino, Ryohei Sasaki. Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients (vol 40, pg 3091, 2020). ANTICANCER RESEARCH. 2020. 40. 8. 4805-4805
Shohei Komatsu, Yusuke Demizu, Nor Shazrina Sulaiman, Kazuki Terashima, Masaki Suga, Masahiro Kido, Hirochika Toyama, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, et al. Space-making particle therapy for sarcomas derived from the abdominopelvic region. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2020. 146. 194-199

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Patents (4)：

放射線治療用スペーサー
放射線治療剤
放射線治療剤(中)
放射線治療剤

Books (22)：

眼科検査ガイド第2版 / 超音波・放射線・画像診断 5)PET, SPECT, ガリウムシンチ
文光堂 2016
外来患者をサポートするがん薬物療法マネジメントブック / 第2章がん薬物療法のマネジメントに役立つ情報と活用術、3.検査所見 2)異常所見画像
株式会社じほう 2016
耳鼻咽喉科・頭頸部外科研修ノート改訂第2版 / 第7章放射線治療
診断と治療社 2016
Radiotherapy / New paradigm of radiotherapy for bone metastasis
INTECH 2016
Non-woven Fabrics / Medical Application of Nonwoven Fabrics: Intra-abdominal Spacers for Particle Therapy.
INTECH 2016

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Lectures and oral presentations (598)：

放射線治療のための金ナノ粒子内包アルブミンインプリントナノゲルの創製
(日本化学会第99春季年会 (2019) 2019)
Radiation therapy for pancreatic cancer using moluculaly imprintednanogels imcopolating gold nanoparticles
(日本化学会第99春季年会 (2019) 2019)
Gold nanoparticle incorporated polymer nanogels for radiation therapy
(第66回応用物理学会春季学術講演会 2019)
稀な松果体乳頭状腫瘍に対して放射線治療を施行した症例
(第321回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント) 2019)
IMRTについて ~有望な放射線治療とは~
(第37回日本口腔腫瘍学会 2019)

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Education (1)：

- 2001 Kobe University Graduate School of Medicine

Professional career (1)：

博士(医学) (神戸大学)

Committee career (2)：

2014/12 - 2024/11 JASTRO Director, Editor-in-chief
1994/04 - 2020/03 日本医学放射線学会評議員

Awards (13)：

2024/10 - Ministry of Education, Culture, Sports, Science and Technology The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Awards for Science and Technology, Development Category
2023/10 - Kobe university president award
2022/10 - Kobe University President award
2021/10 - Kobe University President award
2020/10 - Kobe University President award

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Association Membership(s) (6)：

THE JAPANESE RADIATION RESEARCH SOCIETY , Japanese breast cancer society , 日本ミトコンドリア学会 , Amecian Society of Therapeutic Radiation Oncology , 日本放射線腫瘍学会 , 日本医学放射線学会

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