Noguchi Hiroshi

ノグチヒロシ | Noguchi Hiroshi

Affiliation and department：
Other affiliations (1)：

静岡県立大学客員教授

Research field (3)： Pharmaceuticals - chemistry and drug development , Pharmaceuticals - chemistry and drug development , Molecular biochemistry

Research keywords (5)： biosynthesis , 生薬学 , 生物有機科学 , Pharmacognosy , Biological Organic Chemistry

Research theme for competitive and other funds (26)：

2016 - 2020 Susceptibility HLA alleles and the biological contribution of HLA for the pathogenesis of Behcet's disease or Scleroderma in East Asia
2016 - 2019 Development of comprehensive calculation method of HLA-peptide affinity and application to elucidation of the pathogenesis of Behcet's disease
2014 - 2017 Unprecedented enzyme-catalyzed generation of complexity in fumagillin-pseurotin biosynthesis
2013 - 2016 多様な植物ポリケタイド生合成機構の統合化
2011 - 2015 Genetic contribution of HLA-A alleles for the pathogenesis of Behcet disease in East Asia

2011 - 2015 Enzyme engineering for natural product biosynthesis

2010 - 2013 各種ポリケタイド生合成酵素による分子多様性の創出

2010 - 2012 New mutagenesis approaches to study gene function in crop

2010 - 2012 Application of gene targeting by homologous recombination as a biothecnological tool for rice functional genomics.

2010 - 2012 Reverse genetics and recombination

2008 - 2009 植物ポリケタイド生合成工学による分子多様性の創出

2005 - 2006 Combinatorial Biosynthesis of Plant Polyketides and Polyprenoids

2003 - 2004 Formation of unnatural novel polyketides and isoprenoids from alternate and/or nonphysiological substrate by the engineered plant enzymes

2001 - 2002 Functional diversity of chalcone synthase

1998 - 1999 4' Deoxytpe Chalcone Synthase from Scutellaria baicalensis

1998 - 1998 薬用植物に関わる有用遺伝子の解析と応用への新展開

1994 - 1995 Structural Studies on Reactive Complexes for Highly Selective Organic Reactions

1993 - 1994 The Study on Seaching for the Biologically Active Compounds Containd in the Medicinal Plants

1993 - 1994 The Research on the Production of Usefull Compounds by the Control of Regulations in the Biosynthesis of Secondary Metabolism

1993 - 1993 薬用植物におけるフラボノイド類の区別的発現機構

1992 - 1992 葉用植物におけるフラボノイド類生産の区別的発現

1991 - 1991 薬用植物におけるフラボノイド類生産の基礎研究

1989 - 1989 カンゾウ毛状根によるGlycyrrhiginの生産

Biosynthesis of Purple sweet potato pigment

Search for bioactive compounds from medicinal plants

Biosynthesis of Secondary metabolites

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Papers (151)：

Yaowared Chulikhit, Wichitsak Sukhano, Supawadee Daodee, Waraporn Putalun, Rakvajee Wongpradit, Charinya Khamphukdee, Kaoru Umehara, Hiroshi Noguchi, Kinzo Matsumoto, Orawan Monthakantirat. Effects of Pueraria candollei var mirifica (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain. Molecules. 2021. 26. 11. 3442-3442
Toshikatsu Kaburaki, Hisae Nakahara, Rie Tanaka, Kimiko Okinaga, Hidetoshi Kawashima, Youichiro Hamasaki, Thanyada Rungrotmongkol, Supot Hannongbua, Hiroshi Noguchi, Makoto Aihara, et al. Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet's uveitis. PloS one. 2019. 14. 9. e0222384
Masuya T, Tsunematsu Y, Hirayama Y, Sato M, Noguchi H, Nakazawa T, Watanabe K. Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions. Organic & biomolecular chemistry. 2019. 17. 2. 234-239
Kongkaew S, Rungrotmongkol T, Punwong C, Noguchi H, Takeuchi F, Kungwan N, Wolschann P, Hannongbua S. Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis. Scientific reports. 2019. 9. 1. 745
Md. Abdul Muhit, Kaoru Umehara, Hiroshi Noguchi. α-Keto tetrahydrofuran lignan glucosides from the Bangladeshi medicinal plant Terminalia citrina inhibit estradiol (E2) induced proliferation in cancer cells. Phytochemistry. 2018. 145. 161-167

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MISC (43)：

松井崇, 楊新美, 周暁希, 児玉猛, 森貴裕, 野口博司, 阿部郁朗, 森田洋行. アサ由来ポリケタイド閉環酵素のポリケタイド閉環機構の解明. 日本結晶学会年会講演要旨集. 2016. 2016. 47
森田洋行, 楊新美, 松井崇, 児玉猛, 森貴裕, 周暁希, 野口博司, 阿部郁朗. アサ由来ポリケタイド閉環酵素のX線結晶構造解析. 日本薬学会年会要旨集(CD-ROM). 2016. 136th. ROMBUNNO.29R-AM01
Kodama Takeshi, Matsui Takashi, Mori Takahiro, Tadakoshi Tesuhiro, Noguchi Hiroshi, Abe Ikuro, Morita Hiroyuki. Structure-function analyses of two novel plant type III polyketide syntheses obtained from medicinal plant Evodia rutaecarpa. Pacifichem 2015. 2015
森田洋行, 楊新美, 松井崇, 児玉猛, 周暁希, 森貴裕, 野口博司, 阿部郁朗. アサ由来ポリケタイド閉環酵素のX線結晶構造解析. 酵素工学研究会講演会講演要旨集. 2015. 74th. 55
児玉猛, 野口博司, 阿部郁朗, 森田洋行. ゴシュユ由来新規III型ポリケタイド合成酵素のcDNAクローニングと機能解析. 日本薬学会年会要旨集(CD-ROM). 2015. 135th. ROMBUNNO.26P-PM06

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Works (2)：

lpomoea属植物のカルコン合成酵素の解析
1997 -
Chalcone Synthase in lpomoea plants
1997 -

Education (4)：

1975 - 1979 東京大学大学院薬学系研究科薬学専攻
- 1979 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- 1975 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
- 1975 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (2)：

(BLANK) (The University of Tokyo)
(BLANK) (The University of Tokyo)

Work history (8)：

2020/04 - 現在 Nihon Pharmaceutical University
2016/04 - 現在 University of Shizuoka
2016/04 - 2020/03 Nihon Pharmaceutical University Nihon Pharmaceutical University
1995/09 - 2016/03 University of Shizuoka School of Pharmaceutical Sciences
1994/04 - 1995/08 The University of Tokyo Faculty of Pharmaceutical Sciences

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Committee career (3)：

2006 - 2008 日本学術会議連携会員
2001 - 日本植物細胞分子生物学会評議員
2001 - 日本生薬学会幹事

Awards (1)：

2015/09 - 日本生薬学会生薬学会賞

Association Membership(s) (4)：

日本食品化学学会 , 日本植物細胞分子生物学会 , 日本生薬学会 , 日本薬学会

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