Research theme for competitive and other funds (26)：
2023 - 2028 Photosynthesis ubiquity: Supramolecular complexes and their regulations to enable ph otosynthesis all around the globe
2021 - 2026 Higher depeleopemt of disease-drug molecular path graph system
2020 - 2024 天然変性ヒストン様蛋白質による、結核菌の個性の創出と多様性獲得の分子機構
2020 - 2023 Functional analysis of novel Cas protein candidates for development of new genetic engineering technology
2017 - 2022 創薬等ライフサイエンス研究を促進する研究支援とデータサイエンス
2017 - 2021 Application of supramolecular graph system to GWAS analyses
2017 - 2020 超分子グラフシステムによるGWAS解析の研究
2015 - 2018 Construction of analyses basis for understanding rare variants using protein structural information
2014 - 2017 Structural study on the clamp PCNA-loading mechanism by the clamp loader RFC
2013 - 2016 Attempts in unifying biological molecular data via graph methods
2012 - 2016 Structural analysis to investigate the coordinating role of DNA clamp in replisome
2012 - 2016 超分子モデリングパイプラインの構築
2013 - 2015 生体分子構造データのグラフによる統一の試み
2008 - 2011 Molecular mechanism of aragonite crystal formation by proteins from Pteria penguin pearl shell, and its application to the development of functional materials
2008 - 2010 実践による超分子ネットワークモデリングシステムの開発
2005 - 2008 実践による超分子ネットワークモデリングシステムの開発
2005 - 2008 Development of super-molecule modelling system out of practices
1999 - 2008 Glyco-structural bioinformatics on X-ray crystallography
2002 - 2004 Clarification of Carbohydrate-Recognition Mechanisms of Gralectins which Evolved via Accelerated Substitution and Their Application for Biotechnology
2000 - 2004 Decoding of genome function and evolution based on the 3D structures of proteins
2000 - 2001 実験的・理論的手法を組み合わせたガレクチン天然リガンドの探索
2000 - 2001 ガレクチンをテンプレートにした糖鎖制限酵素の開発
1999 - 2000 Protein engineering of ascorbate oxidase and its application to clinical diagnostics and food atorage
1998 - 1998 キメラヘモグロビン結晶構造による蛋白質構造ブロック界面の分子進化機構の研究
1996 - 1996 モジュール置換キメラグロビンの結晶構造解析
1995 - 1996 Automatic adjusting system of high-intensity focusing mirror optics using for the collection of X-ray diffraction data from protein micro crystals
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Papers (109)：
Kohdai Yamada, Ryouhei Shioya, Kohei Nishino, Hirotake Furihata, Atsushi Hijikata, Mika K. Kaneko, Yukinari Kato, Tsuyoshi Shirai, Hidetaka Kosako, Tatsuya Sawasaki. Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding. Nature Communications. 2023. 14. 1
Tatsuro Nishikino, Atsushi Hijikata, Seiji Kojima, Tsuyoshi Shirai, Masatsune Kainosho, Michio Homma, Yohei Miyanoiri. Changes in the hydrophobic network of the FliGMC domain induce rotational switching of the flagellar motor. iScience. 2023. 26. 8. 107320-107320
Jun-ichi Akagi, Masayuki Yokoi, Yumi Miyake, Tsuyoshi Shirai, Tomohiro Baba, Young-Man Cho, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Kumiko Ogawa. A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis. Journal of Biological Chemistry. 2023. 105002-105002
Takahiro Hayashi, Naoko Yano, Kengo Kora, Atsushi Yokoyama, Kanako Maizuru, Taisei Kayaki, Kinuko Nishikawa, Mitsujiro Osawa, Akira Niwa, Toshiki Takenouchi, et al. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Human molecular genetics. 2023. 32. 10. 1683-1697
Yasuhiro Isogai, Hiroshi Imamura, Tomonari Sumi, Tsuyoshi Shirai. Improvement of Protein Solubility in Macromolecular Crowding during Myoglobin Evolution. Biochemistry. 2022
Hirokazu Nishida, Yoda Takuya, Maiko Tanabe, Toshiyuki Tsuji, Takao Yoda, Tsuyoshi Shirai, Haruko Takeyama, Yoshizumi Ishino. Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA. GENES & GENETIC SYSTEMS. 2016. 91. 6. 367-367
真柳 浩太, 石野 園子, 高藤 三加, 光岡 薫, 白井 剛, 清成 信一, 西田 洋一, 神田 大輔, 森川 耿右, 石野 良純. 分子認識と環境応答における分子機構解明を目指す電子顕微鏡学 単粒子解析により明らかにされたreplisomeの切り替え機構(Switching mechanism of the replisome as revealed by single particle analysis). 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [1S13-4]
Hirokazu Nishida, Takuya Yoda, Maiko Tanabe, Tsuyoshi Shirai, Haruko Takeyama, Yoshizumi Ishino. Effects of the PCNA-DNA interactions on the DNA polymerase/exonuclease reactions by archaeal replicative DNA polymerase. GENES & GENETIC SYSTEMS. 2015. 90. 6. 388-388
