Rchr
J-GLOBAL ID：200901030602809832
Update date: Mar. 19, 2026
Ohashi Kazuhiko
オオハシ カズヒコ | Ohashi Kazuhiko
Affiliation and department：
Job title：
Professor
Research field (1)：
Veterinary medicine
Research keywords (2)：
細胞生物学
, 感染免疫
Research theme for competitive and other funds (65)：
- 2023 - 2027 Development of cocktail vaccines against poultry red mites using the recombinant turkey herpesvirus
- 2023 - 2027 Development of cocktail vaccines against poultry red mites using the recombinant turkey herpesvirus
- 2023 - 2026 The roles of polymorphism in Meq on the pathogenicity of Marek's disease virus and their application for the vaccine development
- 2023 - 2026 The roles of polymorphism in Meq on the pathogenicity of Marek's disease virus and their application for the vaccine development
- 2022 - 2025 Development of evolving therapeutic technologies to address unmet medical needs for intractable diseases in animals
- 2022 - 2025 Development of evolving therapeutic technologies to address unmet medical needs for intractable diseases in animals
- 2020 - 2023 The search for the candidate molecule for the vaccine to control a wide range of ectoparasite species of chickens
- 2019 - 2022 Experimental study for practical application of cross-sectional cancer therapy in companion animals
- 2018 - 2021 Development of a method to control poultry red mites using recombinant Marek's disease virus that secretes a vaccine antigen
- 2017 - 2020 Analysis of the molecular mechanism for the increase in the virulence of Marek's disease virus
- 2016 - 2019 Analysis of genetic polymorphism of poultry red mites in the world and search for candidate molecules of anti-mite vaccines
- 2016 - 2018 Comprehensive analysis of molecules expressed on the midgut of poultry red mites for the development of new anti-mite vaccines
- 2014 - 2018 Empirical research for bovine leukemia control strategy
- 2014 - 2017 Studies on the molecular mechanisms for the increase in MDV virulence in the field
- 2013 - 2017 Pathologic analysis of malignant infectious diseases in foreign livestock and its applications for establishment of novel control strategy.
- 2011 - 2015 Establishment of control measure for bovine leukemia based on risk analysis of virus transmission
- 2012 - 2014 神経疾患を引き起こすレトロウイルスの海外拡散の実態とゲノム多様性
- 2011 - 2014 Studies on the immunoinhibitory mechanisms of Marek's disease virus and its application for adjuvant
- 2010 - 2014 レトロウイルスが引き起こす多様な神経障害の分子基盤
- 2010 - 2012 Elucidation of the evasion mechanism of cytokine storm in disease resistant native livestock
- 2009 - 2011 Identification and characterization of factors involved in the resistance to Marek' s disease in chickens and wild waterfowls
- 2008 - 2011 The origin and genome diversity of retroviruses causing neurological disorders
- 2008 - 2010 がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御
- 2008 - 2010 Studies on the molecular mechanisms for Marek's disease virus to increase its virulence in the field
- 2006 - 2009 Pathological and molecular biological analysis of nervous lesions caused by glioma-inducing retroviruses
- 2006 - 2008 Genetic analysis of drug resistant trypanosomes
- 2008 - 鳥類由来感染症の疫学的研究
- 2008 - Epidemiological study on infectious diseases of wild and domestic birds
- 2006 - 2007 抗糖脂質モノクローナル抗体のイヌ型抗体化とメラノーマ治療への応用
- 2006 - 2007 ダニの唾液由来免疫抑制因子を用いるダニ媒介性病原体の伝播阻止
- 2005 - 2007 レトロウイルス性グリオーマモデルにおける遺伝子サイレンシングの効果
- 2005 - 2007 Tick vaccine development by using tick testis-derived factors
- 2004 - 2007 Phylogenetic analysis of avian retroviruses with neuropathogenicity in central nervous system
- 2004 - 2006 Development of new vaccine strategies against Marek's disease virus with increased virulence
- 2004 - 2005 サイトカイン遺伝子多型解析による疾患抵抗性家畜の選抜
- 2003 - 2005 Molecular characterization of Marek's disease virus genomes isolated from white-fronted geese
- 2003 - 2005 Genetic diversity of bovine lentivirus distributed in south Asian countrirs
- 2003 - 2005 Oncogenesis of retrovirus induced-glioma and the development of animal model
- 2003 - 2005 Molecluar mechanism of propagation of abnormal prion protein in the cells
- 2003 - 2004 組み換えH鎖抗体を用いた血液脳関門デリバリーによる脳炎の治療
- 2003 - 2004 Search for biological active molecules from tick salivary glands
- 2001 - 2003 Molecular mimicry of carbohydrate receptors and its application for the control of infectious diseases
- 2000 - 2003 Development of anti-tick vaccine
- 2001 - 2002 Analysis of tick-encoded immunoregulatory serine proteinase inhibitors (serpins)
- 2000 - 2001 THE CHARACTERISTIC OF SO-CALLED FOWL GLIOMA, WHICH IS A UNIQUE CENTRAL NERVOUS SYSTEM NEOPLASM IN ANIMALS CAUSED BY A RETROVIRUS
- 2000 - 2001 Molecular mechanisms of diversity of theileria parasite genes distributed in middle and South America
- 1999 - 2000 Preparation of the recombinant Marek's disease virus which can induce apoptosis in tumor cells and its application for an anti-tumor vaccine.
- 1999 - 2000 Molecular approach to analyze strategies of pathogens in wildlife for acuierement of new host
- 1999 - 2000 Molecular mechanisms of diversity of theileria parasite genes and control of the disease
- 1998 - 2000 Molecular analysis of intraerythrocytic parasite population dinamics and acquirement of biological diversity
- 1998 - 1999 PLANT EXPRESSIONS OF CYTOKINES AND IIST APPILICATIONS FOR ANIMAL DISEASE CONTROL
- 1998 - 1999 Molecular evolution of Theileria parasites in Southern Asia
- 1998 - 1999 マレック病腫瘍化におけるアポトーシス関連及び癌抑制遺伝子の発現動態の解析
- 1997 - 1999 Immunological modulation and control of infections diseases by cytokaines
- 1997 - 1998 GENOME ANALYSIS OF THEILERIA PARASITES
- 1995 - 1998 Molecular escape mechanisms of Theileria parasites
- 1996 - 1997 ANALYSIS OF INTRACELLULAR ADAPTATION MECHANISMS OF PROTOZOAN PARASITES AND HOST ELIMINATION
- 1996 - 1997 Molecular evolution of Theileria parasites in Pacific area
- 1996 - 1996 ディファレンシャルデスプレイ法による鶏免疫関連分子の解析と病態変化への応用
- 1995 - 1996 Molecular epidemiology of Theileria infections in Africa : Characterization of parasites of wild and domestic animals.
- 1995 - 1995 鶏CD4:CD8遺伝子のクローニングによるマレック病ウイルスの癌化標的細胞の解析
- 1994 - 1994 鶏Fas抗原遺伝子のフローニングによるマレック病ワクチンの作用機序の解明
- 1992 - マレック病ウイルスによる腫瘍化の分子メカニズムの解析、ワクチン作用機序の解明
- 1992 - 動物感染症に対する免疫応答の分子機序の解明
- 1992 - Characterization of molecular mechanisms of immune responses against infectious diseases in animals
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Papers (196)：
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Satoshi Takagi, Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Yumiko Kagawa, Kenji Hosoya, Akinori Yamauchi, Ayano Kudo, Shintaro Kamo, Sangho Kim, et al. Clinical efficacy of anti-programmed death ligand 1 antibody HFC-L1/c4G12 in dogs with malignant tumors: an exploratory study. The Journal of veterinary medical science. 2025. 87. 12. 1419-1425
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Mari Ikehata, Tomohiro Okagawa, Hayato Nakamura, Naoya Maekawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi, Satoru Konnai. Enhancement of Vaccine-Induced T-Cell Responses by Probiotics in Calves. Vaccines. 2025. 13. 11
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Jumpei Sato, Aoi Kurokawa, Yoshinosuke Motai, Shunsuke Yamagami, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Benedikt B Kaufer, et al. Two distinct polymorphisms in the basic region of Meq protein of marek's disease virus alter pathological progression and clinical manifestations. Virology journal. 2025. 22. 1. 303-303
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Kenji Hosoya, Sangho Kim, Ryohei Kinoshita, Naoya Maekawa, Satoru Konnai, Satoshi Takagi, Michihito Tagawa, Yumiko Kagawa, Tatsuya Deguchi, Ryo Owaki, et al. Exploratory, Randomized, Dose-Response Study of the Anti-PD-L1 Antibody HFC-L1/c4G12 in Dogs with Pulmonary Metastatic Oral Malignant Melanoma. Veterinary sciences. 2025. 12. 9
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Wisa Tiyamanee, Tomohiro Okagawa, Shinji Yamada, Mari Ikehata, Hayato Nakamura, Maho Inoue, Naoya Maekawa, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi, et al. Evaluation of PD-L1 and TIM-3 Pathways in T Cells During Experimental Bovine Leukemia Virus Infection in Sheep. Veterinary sciences. 2025. 12. 9
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MISC (342)：
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堀川壮琉, 岡川朋弘, 岡川朋弘, 前川直也, 北内諒, 山家崇史, 村田史郎, 大橋和彦, 加藤史樹, 今内覚, et al. 馬精上皮腫に対する免疫チェックポイント阻害剤を用いた臨床試験研究の1例. 北海道獣医師会雑誌. 2025. 69. 8
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もたい吉之介, 村田史郎, 村田史郎, 佐藤純平, 山上竣裕, SHWE Win Yee, 堀尾文彌, 前川直也, 岡川朋弘, 今内覚, et al. Effect of polymorphisms in the meq gene of Marek’s disease virus distributed in Japan on the pathogenicity and transcriptional regulation. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2024. 71st
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佐藤純平, 村田史郎, 村田史郎, もたい吉之介, 山上竣裕, 堀尾文彌, SHWE Win Yee, 前川直也, 岡川朋弘, 今内覚, et al. Effect of polymorphisms in the basic region of Meq protein of Marek’s disease, an avian oncogenic herpesvirus, on virulence. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2024. 71st
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松原幸芽, 岡川朋弘, 斎藤益満, 松平崇弘, 直亨則, 神谷可菜, 齋藤麻矢, 前川直也, 村田史郎, 大橋和彦, et al. 非典型的な地方病性牛伝染性リンパ腫症例のRAISING法を用いた性状解析. 日本獣医学会学術集会講演要旨集. 2024. 167th
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飯高早紀子, 前川直也, 今内覚, 出口辰弥, 岡川朋弘, 高木哲, 高木哲, 鈴木定彦, 鈴木定彦, 村田史郎, et al. 抗PD-L1抗体により治療した悪性黒色腫の犬における血清バイオマーカーの探索. 日本獣医学会学術集会講演要旨集. 2024. 167th
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Education (6)：
Professional career (2)：
- Ph. D. (コーネル大学(アメリカ合衆国))
- 獣医学修士 (北海道大学)
Work history (11)：
- 2007 - 2008 Hokkaido University Graduate School of Veterinary Medicine
- 2008 - - 北海道大学大学院獣医学研究科 動物疾病制御学講座 教授
- 2008 - - Professor
- 2001 - 2007 Hokkaido University Graduate School of Veterinary Medicine
- 2001 - 2007 Associate Professor
- 1995 - 2000 Hokkaido University Graduate School of Veterinary Medicine
- 1995 - 2000 Research Associate
- 1993 - 1995 北海道大学獣医学部 家畜伝染病学講座 助手
- 1993 - 1995 Research Associate
- 1985 - 1989 三楽(現メルシャン)株式会社中央研究所 生物評価室 研究員
- 1985 - 1989 Researcher
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Awards (1)：
Association Membership(s) (4)：
日本ウイルス学会
, 日本獣医学会
, 日本癌学会
, 日本免疫学会
