Rchr

J-GLOBAL ID：200901030897807569 Update date: Apr. 10, 2024

TAKEDA Shin'ichi

タケダシンイチ | TAKEDA Shin'ichi

Affiliation and department：
Other affiliations (3)：

Tokushima University Visiting Professor
Toho University School of Medicine Invited lecturer
Tohoku University School of Medicine Invited lecturer

Research field (1)： Neurology

Research keywords (8)： nNOS , 幹細胞移植治療 , 遺伝子治療 , 筋ジストロフィー , Utrophin , Stem Cell , Gene Therapy , Muscular Dystrophy

Research theme for competitive and other funds (42)：

2018 - 2021 Development of DMD exon 3-9 skipping therapy using iPSc
2016 - 2019 Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition.
2016 - 2019 application of induced mesenchymal stem cells from human iPS cells to cell therapy in muscular dystrophy
2015 - 2018 Exon 45 skipping theraphy using iPS cells deleted exons 46-55 in the DMD gene
2015 - 2018 Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs

2014 - 2017 Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy

2013 - 2017 Establishment of chemical RNA editing method for genetic code resoration therapy

2013 - 2016 Development of Antisense Mediated Therapy for Exons Duplication in Duchenne Muscular Dystrophy.

2013 - 2016 Elucidation of the mechanisms of skeletal muscle hypertrophy by intracellular calcium concentration.

2012 - 2015 Induction of transplantable myogenic cells from pluripotent stem cells

2012 - 2015 Molecular characterization of a HECT-type E3 ubiquitin ligase that is encoded in the WWP1 gene responsible for chicken muscular dystrophy.

2011 - 2015 Molecular signaling in neuromuscular synaptogenesis and myasthenia

2010 - 2012 Study on Mechano-Sensing Channel in muscular dystrophic dog

2009 - 2012 Molecular pathogenesis of neonatal fulminant dystrophic dog and fetal therapy

2009 - 2011 The elucidation of the molecular mechanisms of NO-mediated muscle atrophy

2008 - 2010 Study on molecular regulation of muscle regeneration by mesenchymal cells

2007 - 2008 Molecular mechanism of selective degeneration of Purkinje fibers in dystrophic dog

2006 - 2007 Analysis of the roles of POMGnT1 in development and maintenance of certral nervous system and skeletal muscle

2004 - 2005 Analysis of roles for osteopontin in muscle regeneration

2004 - 2005 THE RELEVANCE OF THE SELECTIVE DAMAGE OF PURKINJE FIBER AND THE ABNORMAL ELECTROCARDIOGRAM IN CANINE X-LINKED MUSCLAR DYSTROPHY

2003 - 2005 Elucidation of Molecular Mechanism of Muscle Regeneration of Dystrophin-dificient Duchenne Muscular Dystorophy

2003 - 2004 Level and clinical picture of myocardial failure in Duchenne type muscular dystrophy

2002 - 2003 筋ジストロフィーの中枢神経障害:ジストロフィン複合体と相互作用する分子の解明

2002 - 2003 Endoplasmic reticulum stress-induced apoptosis in pre-necrotic period in skeletal muscles of laminin-2 deficiency

2000 - 2002 RESEARCH ON THE PATHOGENESIS AND PATHOPHYSIOLOGY OF HEREDITARY CERULOPLASMIN DEFICIENCY (ACERULOPLASMINEMIA)

1999 - 2001 Elucidation of molecular mechanism of utrophin expression in dystrophic skeletal muscle and its application to molecular therapy

1999 - 2000 ノックアウトマウスを用いた筋ジストロフィーの中枢神経障害に関する分子生物学的研究

1998 - 2000 Elucidation of Molecular Mechanism of Muscle Degenaration using Developmental Biology Technique and development of therapeutics

1997 - 2000 Molecular Immunology study of t

1997 - 1999 Production of muscular dystrophy mice by molecular engineering

1997 - 1998 Research on Therapy of Ceruloplasmin Deficiency using Adenovirus Vector

1996 - 1997 Regulation of cell growth and cell differentiation during muscle development.

1996 - 1996 セルロプラスミン欠損によるヘモジデロ-シスの病態発生機序に関する研究

1995 - 1996 標的遺伝子組換えによるメロシンM鎖の発現と機能の異常に関する研究

1995 - 1995 心筋におけるジストロフィン遺伝子の転写調節に関する分子生物学的研究

1994 - 1995 Molecular genetic research on the peculiar form of Becker Muscular Dystrophy (BMD), where cardiac muscle is preferentially involved

1994 - 1994 心筋におけるジストロフィン遺伝子の転写調節に関する分子生物学的研究

1993 - 1994 Basic Research of Gene Therapy using Adenoviral Vector for Muscular Dystrophy

1992 - 1994 ジストロフィン関連遺伝子のクローニング

1992 - 1993 Molecular Genetic Diagnosis and Prevention of Muscular Dystrophies

筋ジストロフィーにおける筋細胞の変性と壊死の分子病態学遺伝性筋疾患への遺伝子治療に関する基礎研究遺伝性筋疾患への幹細胞移植治療の基盤研究

Molecular Pathology of muscle cell degeneration in muscular dystrophies Basic research on gene therapy of hereditary muscle disease Basic research on stem cell therapy of hereditary muscle disease

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Papers (385)：

Michihiro Imamura, Hirokazu Matsumoto, Hideyuki Mannen, Shin’ichi Takeda, Yoshitsugu Aoki. The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function. In Vitro Cellular & Developmental Biology - Animal. 2024
Tsukasa Tominari, Masaru Takatoya, Toshiya Matsubara, Michio Matsunobe, Daichi Arai, Chiho Matsumoto, Michiko Hirata, Shosei Yoshinouchi, Chisato Miyaura, Yoshifumi Itoh, et al. Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle. International Journal of Molecular Sciences. 2023. 25. 1. 303-303
Shin’ichi Takeda. Memories of Professor François Gros. Comptes Rendus. Biologies. 2023. 346. S2. 1-5
野上健一郎, 中村治雅, 武田伸一. 【デュシェンヌ型筋ジストロフィー(DMD)診療の最前線】疫学研究世界のDMDの疫学研究. Progress in Medicine. 2023. 43. 11. 1005-1010
Fusako Sakai-Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe-Suzuki. Antioxidants restore store-operated Ca2+ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein. FASEB bioAdvances. 2023. 5. 11. 453-469

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MISC (387)：

Hiromi Hayashita-Kinoh, Posadas Herrera-Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada. Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment. MOLECULAR THERAPY. 2022. 30. 4. 494-494
Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Shin'ichi Takeda, Takashi Okada. Anti-Inflammatory Properties of IL-10-Expressing Multipotent Mesenchymal Stromal Cells for Duchenne Muscular Dystrophy. MOLECULAR THERAPY. 2022. 30. 4. 490-490
Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada. Improved Transduction of DMD Dog with rAAV-Microdystrophin via Multipotent Mesenchymal Cell Pretreatment. MOLECULAR THERAPY. 2021. 29. 4. 287-288
富成司, 松延道生, 松延道生, 高戸谷賢, 平田美智子, 武田伸一, 青木吉嗣, 稲田全規. LC-MSによるヒト骨格筋ジストロフィンの高精度タンパク質定量法の開発. 日本筋学会学術集会プログラム・抄録集. 2021. 7th
Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Kazuhiro Takao, Tsutomu Igarashi, Shin'ichi Takeda, Takashi Okada. Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment. MOLECULAR THERAPY. 2020. 28. 4. 327-327

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Patents (1)：

短縮型ジストロフィン特許出願日:平成10年5月8日特許出願公開番号:特開平11-318467号特許出願公開日:平成11年11月24日

Books (13)：

理科年表2020、第93冊、生物部
丸善出版(株) 2019
実験医学(増刊)超高齢社会に挑む骨格筋のメディカルサイエンス
(株)羊土社 2018
Muscle Cell and Tissue
IntechOpen, London 2018
Methods in molecular biology
2017
先端治療技術の実用化と開発戦略
株式会社技術情報協会 2017 ISBN:9784861046506

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Lectures and oral presentations (39)：

クリニカル・イノベーション・ネットワークのあゆみ
(第1回国際レジストリフォーラム 2019)
Antisense treatment to correct dystrophin-deficiency in the brain.
(European Nuero Muscular Centre (ENMC), 2019)
エクソン・スキップ治療薬(NS-065/NCNP-01)の開発
(2019年日本製薬工業協会医薬品評価委員会総会シンポジウム「医薬品の新規モダリティ」 2019)
遺伝性疾患における遺伝子治療の現状と今後の展望
(第61回歯科基礎医学会学術大会、メインシンポジウム3「骨と筋の遺伝性疾患の遺伝子治療:現状と今後の展望」 2019)
宇宙空間と筋萎縮
(徳島大学大学院2019年度「宇宙と栄養・医学概論」特別講義 2019)

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Education (2)：

- 1981 Shinshu University Graduate School
- 1977 Akita University School of Medicine Faculty of Medicine

Professional career (1)：

M.D., Ph.D. (Guraduate School Shinshu University)

Work history (10)：

2020/04 - 現在国立精神・神経医療研究センター神経研究所名誉所長・顧問
2018/04 - 現在国立精神・神経医療研究センター理事
2015/04 - 2018/03 National Center of Neurology and Psychiatry National Institute of Neuroscience Director-General
2000/10 - 2018/03 National Center of Neurology and Psychiatry Department of Molecular Therapy, National Institute of Neuroscience Director
2008/10 - 2015/03 National Center of Neurology and Psychiatry Translational Medical Center Director

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Committee career (12)：

- 現在日本神経学会評議員
- 現在日本筋学会理事長
- 現在日仏医学会理事
- 現在 Am J Pathol Associate editor
- 現在 J Neuromuscular Diseases Associate editor

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Awards (6)：

2000 - ヒューマンフロンティアサイエンスプロジェクト受賞(平成12年)
2000 - Award of Human Science Frontier Project
1993 - 三共生命科学研究振興財団研究基金受賞(平成5年)
1993 - 公益信託医用薬物研究奨励富岳基金受賞(平成5年)
1993 - Award of Sankyo Foundation of Life Science

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Association Membership(s) (10)：

European Society of Gene and Cell Therapy , World Muscle Society , Japanese Society of Inflammation and Regeneration , JAPANESE SOCIETY OF NEUROLOGY , アジアオセアニア筋病学センター , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , The Japan Society of Gene Therapy , Societas Neurologica Japonica , Asian Oceanian Myology Center , American Society of Gene Therapy

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