Rchr
J-GLOBAL ID：200901030969692818   Update date: Oct. 03, 2024

Tsubata Takeshi

ツバタ タケシ | Tsubata Takeshi
Affiliation and department：
Nihon University School of Dentistry

About Nihon University School of Dentistry


Job title： Visiting Professor
Homepage URL  (1)： http://www.tmd.ac.jp/imm/index.html
Research field  (2)： Medical biochemistry ,  Immunology
Research keywords  (9)： vaccination ,  ROS ,  vesicular transport ,  apoptosis ,  infection immunity ,  autoimmunity ,  glycan antigens ,  antibody ,  immune response
Research theme for competitive and other funds  (70)：
  • 2021 - 2022 T細胞非依存性免疫応答と細胞内分解
  • 2019 - 2020 核抗原への自己抗体産生における変性自己抗原の役割の解明
  • 2018 - 2020 Glycocalyx(細胞表面糖鎖層)によるBリンパ球活性化制御の研究
  • 2015 - 2018 Analysis of cutaneous lesion in collagen disease induced by intranuclear autoantibody.
  • 2014 - 2018 Bリンパ球に発現するシグレックとその糖鎖リガンドについての研究
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Papers (181)：
  • Chizuru Akatsu, Yuko Naito-Matsui, Hajjaj H.M. Abdu-Allah, Akihiro Imamura, Wang Long, Hideharu Ishida, Hiromu Takematsu, Takeshi Tsubata. Neu5Gc-mediated high affinity interaction is dispensable for CD22 cis-ligands to regulate B cell signaling. Journal of Biological Chemistry. 2024. 107630-107630
  • Chizuru Akatsu, Takahiro Tsuneshige, Nobutaka Numoto, Wang Long, Toshio Uchiumi, Yoshikatsu Kaneko, Masatake Asano, Nobutoshi Ito, Takeshi Tsubata. CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody. Journal of autoimmunity. 2024. 146. 103245-103245
  • Takeshi Tsubata. Siglec cis-ligands and their roles in the immune system. Glycobiology. 2023
  • Zi-Xian Wang, Yi-Qian Pan, Xuexin Li, Takeshi Tsubata, Rui-Hua Xu. Immunotherapy in gastrointestinal cancers: advances, challenges, and countermeasures. Science bulletin. 2023. 68. 8. 763-766
  • Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Hiromu Takematsu, Takeshi Tsubata, Hideharu Ishida. Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors. Glycoconjugate journal. 2023. 40. 2. 225-246
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MISC (54)：
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Patents (2)：
  • Method for promoting immune response comprising inhibiting CD22 function in B cells
  • B細胞におけるCD22機能を抑制することから成る免疫応答の促進方法
Books (40)：
  • B細胞と自己免疫疾患
    臨床免疫・アレルギー科73(5)562-570,科学評論社 2020
  • Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger. In “B Cells in Immunity and Tolerance” ed. by Ji-Yang Wang
    Springer 2020
  • Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi
    Springer 2020
  • Lectin Purification and Analysis: Methods and Protocols:Identification of Siglec Cis-ligands by Proximity Labeling.
    Springer 2020
  • Development of Siglec Regulators. In “Glycoscience: Basic Science to Applications” (ed. by Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishihara, Kenji Kadomatsu, Kazunari Akiyoshi and Kiyoko F. Aoki-Kinoshita)
    Springer 2019 ISBN:9811358559
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Lectures and oral presentations  (313)：
  • Cross-talk between complement pathways and immune system
    (2021)
  • Immunogenic Peptides Derived from SARS-CoV2
    (19th Sugadai Symposium 2021)
  • Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72
    (25TH Congress and General Assembly of the International Union of Crystallography 2021)
  • CD72による死細胞へのB細胞自己免疫応答の抑制
    (第29回日本Cell Death学会学術集会 2021)
  • ギラン・バレー症候群関連遺伝子rare variantと自己免疫応答
    (第20回釧路ニューロサイエンスワークショップ 2021)
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Education (2)：
  • - 1987 Kyoto University Graduate School, Division of Medicine
  • - 1981 Kyoto University Faculty of Medicine
Professional career (1)：
  • Doctor (Kyoto University)
Work history (14)：
  • 2022/04 - 現在 Nihon University School of Dentistry Visiting Professor
  • 2010/04 - 2022/03 Tokyo Medical and Dental University Medical Research Institute Pathophysiology Immunology Professor
  • 2012/04/01 - 2021/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Life Science and Technology Life Science and Technology Immunology Professor
  • 2012/04/01 - 2014/12/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Immunology Professor
  • 2003/04/01 - 2010/03/31 Tokyo Medical and Dental University Director
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Committee career (19)：
  • 2019/06 - 現在 PLoS Biology誌 Editorial Board Member
  • 2008/01 - 現在 BMC Immunology誌 Associate Editor
  • 2008/01 - 現在 The Open Autoimmunity 誌 Board Member
  • 2008/01 - 現在 Self / Nonself誌 Editorial Board Member
  • 2004/01 - 2008/12 BMC Immunology誌 Editorial Board Member
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Awards (5)：
  • 2021/06 - 第85回日本インターフェロン・サイトカイン学会学術集会 ベストプレゼンテーション賞/銅賞(Amin Alborzian Deh Sheikh) A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides
  • 2018/12 - Japanese Society for Immunology Best Presentation Award (Xuexin, Li) Significant associations of human SIGLEC10 polymorphisms with susceptibility to Guillain-Barré syndrome
  • 2017/10 - Deutsche Forschungsgemeinschaft Eugen-und-Ilse-Seibold-Preis, Eugen and Ilse Seibold Prize
  • 2005 - President of Federal Republic of Germany Phillip Franz von Siebold Prize
  • 1996 - 日本生化学会 日本生化学会奨励賞
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