Rchr
J-GLOBAL ID:200901031126879629
Update date: Mar. 09, 2024
Ohara Osamu
オハラ オサム | Ohara Osamu
Affiliation and department:
Job title:
Department Head
Other affiliations (1):
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Chiba University
Group director
Homepage URL (1):
http://www.kazusa.or.jp
Research field (1):
Molecular biochemistry
Research keywords (4):
Technology development of multiomics analysis
, Clinical proteomics
, ゲノミクス
, 1細胞生物学
Research theme for competitive and other funds (35):
- 2022 - 2025 Long-read sequencing analysis for difficult to diagnose cases of primary immunodeficiency
- 2022 - 2025 Characterization of molecular pathogenesis of primary immunodeficiency focusing on host susceptibility to viruses
- 2022 - 2025 遺伝性血栓症の病因(オミックス解析)と病態の解明
- 2019 - 2022 Characterization of etiology of primary immunodeficiency by focusing on host susceptibility to specific pathogens
- 2019 - 2022 Pathophysiological Study on Aortopathy towards Prevention
- 2018 - 2021 Multi-OMICS approaches to investigate molecular pathogenesis of primary immune deficiency
- 2017 - 2019 Roles of TET family in dynamic epigenomic alteration induced by EB virus infection
- 2016 - 2019 Investigation of molecular mechanism and therapeutic target of Chronic Mucocutaneous Candidiasis
- 2016 - 2019 Elucidating the mechanism of NLRP3 inflammasome activation using fluorescence and light emission protein-interaction sensors
- 2015 - 2018 Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation
- 2015 - 2018 Development of personalized lung cancer vaccine targeting neoantigens
- 2015 - 2018 Function of APOBEC3 in EBV-positive T or NK-cell lymphoproliferative diseases
- 2014 - 2017 Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders
- 2014 - 2017 Elucidation of molecular mechanism of cytopenia associated with immunodeficiency/immune disorder
- 2014 - 2017 Establishment of novel diagnosis and analysis of pathogenesis of herediatry lymphoproliferative disorders
- 2014 - 2017 Establishing an innovative platform for the analysis of hemophagocytic lymphohistiocytosis
- 2014 - 2016 Investigation of pathology and development of specific medial care system and treatment associated with FLNA deficiency
- 2013 - 2016 Elucidation of cold-induced gene induction mechanism by analyzing Mendelian-inherited diseases with cold-induced inflammation
- 2013 - 2015 The study to clarify the molecular mechanism of fate decision of activated CD4 T cells
- 2013 - 2015 Establishment of mouse model of chronic mucocutaneous candidiasis disease and use them to find therapeutic target
- 2012 - 2015 Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering
- 2011 - 2014 Analysis and development of medical treatment for autoinflammatory diseases
- 2011 - 2014 Research on molecular mechanisms of break in immunological tolerance in disorders caused by single-gene defect
- 2011 - 2014 Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology
- 2011 - 2012 A study to establish system to evaluate diversities of cell populations of melanoma
- 2010 - 2012 Research for developing of a screening method for the congenital immunodeficiency by KREC/TREC to apply the method to the pathologic analysis
- 2009 - 2011 Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.
- 2009 - 2011 Comprehensive analysis of splicing variants characteristic of acute myelogenous leukemia stem cells
- 2009 - 2010 遺伝子制御ネットワークの動的挙動の解明:制御論的理論解析と実験による検証
- 2009 - 2010 Development of easy and cost-effective mass-screening of severe combined immunodeficiency using neonatal guthrie cards.
- 2004 - 2006 Memory B cell commitment, maintenance and terminal differentiation
- 2001 - 2002 ヒト脳内長鎖cDNA解析データベースを基盤としたマウス扁桃体の情動神経機構の解明
- 1992 - 1994 Studies on neurofilament-deficient quails-an animal model for neuropathology
- 1994 - 免疫ゲノミクス
- Immunogenomics
Show all
Papers (651):
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Takashi Watanabe, Hikaru Hata, Yoshiki Mochizuki, Fumie Yokoyama, Tomoko Hasegawa, Naveen Kumar, Tomohiro Kurosaki, Osamu Ohara, Hidehiro Fukuyama. Development of a new genotype-phenotype linked antibody screening system. 2024
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Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Kawabe Tomohiro, et al. Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey. Arthritis & rheumatology (Hoboken, N.J.). 2024
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Daisuke Nakajima, Ryo Konno, Yasuomi Miyashita, Masaki Ishikawa, Osamu Ohara, Yusuke Kawashima. Proteome Analysis of Serum Purified Using Solanum tuberosum and Lycopersicon esculentum Lectins. International Journal of Molecular Sciences. 2024
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Tadasu Okaya, Takeshi Kawasaki, Shun Sato, Yu Koyanagi, Koichiro Tatsumi, Ryo Hatano, Kei Ohnuma, Chikao Morimoto, Yoshitoshi Kasuya, Yoshinori Hasegawa, et al. Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease. International Journal of Molecular Sciences. 2024
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Shino Nemoto, Tetsuya Kubota, Tomoyuki Ishikura, Manabu Nakayama, Atsuo Kobayashi, Junshi Yazaki, Kazuyo Uchida, Masashi Matsuda, Takashi Kondo, Osamu Ohara, et al. Characterization of metabolic phenotypes and distinctive genes in mice with low-weight gain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024. 38. 1. e23339
more...
MISC (357):
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佐藤 裕範, 伊藤 ありさ, 早田 衣里, 山本 健, 中野 泰至, 山出 史也, 井上 祐三朗, 冨板 美奈子, 川島 祐介, 小原 收, et al. 統合プロテオミクスを用いた小児期シェーグレン症候群の疾患モニタリングとバイオマーカー探索. 日本小児リウマチ学会総会・学術集会プログラム・抄録集. 2023. 32回. 118-118
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佐倉 文祥, 野々山 恵章, 今井 耕輔, 大西 秀典, 八角 高裕, 金兼 弘和, 小原 收, 岡田 賢. プロテオゲノミクス解析を用いた先天性免疫異常症の遺伝子診断. 日本臨床免疫学会総会プログラム・抄録集. 2023. 51回. 81-81
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小原 收. 次世代新生児スクリーニングに向けた胎動 次世代シーケンシングを越えて. 日本マス・スクリーニング学会誌. 2023. 33. 2. 188-188
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小原 收. 遺伝学的検査の受託機関から見た今後の課題. 脳と発達. 2023. 55. Suppl. S233-S233
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高橋 由希子, 川崎 剛, 佐藤 裕範, 長谷川 嘉則, Dudek Steven M., 小原 收, 巽 浩一郎, 鈴木 拓児. 肺血管内皮細胞の炎症応答におけるCD26/DPP4の役割(アンコール演題). 日本呼吸器学会誌. 2023. 12. 増刊. 358-358
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Patents (145):
Books (3):
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外来で見つける先天代謝異常症
中山書店 2023 ISBN:9784521749242
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ヒトマイクロバイオーム
NTS(エヌ・ティー・エス) 2020 ISBN:9784860436599
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バイオ高性能機器・新技術利用マニュアル
共立出版 2004 ISBN:4320056264
Lectures and oral presentations (45):
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次世代シーケンシング(NGS)と難病の遺伝学的検査
(イルミナユーザーグループミーティング 2024)
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プロテオゲノミクス研究の現状と将来展望
(第73回日本電気泳動学会シンポジウム 2023)
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何のための「オミックス解析」?:その必要性と今後の展望
(第46回日本分子生物学会年会ランチオンセミナー 2023)
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Next generation sequencing first? Challenging traditional diagnostic pathways
(2023)
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次世代新生児スクリーニングに向けた胎動:次世代シーケンシングを越えて
(第50回日本マススクリーニング学会学術集会、50周年記念レクチャー 2023)
more...
Professional career (1):
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