tetsushi yoshikawa

ヨシカワ | tetsushi yoshikawa

Affiliation and department：

Research field (1)： Fetal medicine/Pediatrics

Research theme for competitive and other funds (28)：

2024 - 2027 Elucidation of molecular mechanism of MELAS using iPS cells derived from MELAS patients with various heteroplasmy.
2022 - 2025 Development of a simple and rapid diagnostic method for using miRNA as a biomarker
2021 - 2024 Elucidation of the role of HHV-6B infection in the development of medial temporal lobe epilepsy with hippocampal sclerosis
2021 - 2024 Development of novel gene therapy for MELAS by editing mitochondorial DNA
2019 - 2022 Syndromic testing panel for central nervous system infections using the LAMP method

2018 - 2021 Development of recombinant genital herpes vaccine based on the live attenuated rotavirus vaccine

2016 - 2019 The point of care testing of herpesvirus infection by LAMP method

2015 - 2019 Pathogenesis of rotavirus antigenemia and extraintestinal manifestations

2014 - 2017 Development of a method for measuring HHV-6A and HHV-6B specific antibodies using synthetic peptides

2013 - 2016 Development of quantitative method by loop-mediated isothermal amplification (LAMP) using cycling probe.

2013 - 2016 Analysis of pathogenesis of severe complications caused by rotavirus infection

2011 - 2013 HHV-6 species specific serological assay

2010 - 2012 Development of quantitative multiplex DNA amplification method by loop-mediated isothermal amplification (LAMP) using Qprobe.

2009 - 2011 A multicenter study on early diagnosis and prognostic prediction of acute encephalopathy in childhood

2008 - 2010 Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention

2008 - 2010 Analysis of pathogenesis of HHV-6 encephalitis at the time of primary infection and reactivation of the virus

2007 - 2009 Development of a novel DNA amplification methods by loop-mediated isothermal amplification in human herpesvirus infections.

2005 - 2007 Analysis of the natural course of HHV-6 and 7 infections ; to elucidate the remaining problems for the infections.

2005 - 2007 Analysis for the pathogenesis of HHV-6 encephalitis in transplant recipients and establishment of guideline for the treatment

2003 - 2004 病原性大腸菌LTトキシンによるウイルス感染と腫瘍の同時制御に関する研究

2002 - 2004 Analysis of the pathogenesis of acute GVHD like illness caused by HHV-6 infection after hematopoietic stem cell transplantation

2002 - 2003 リンパ球親和性ヘルペスウイルスによる白血病治療の基礎的研究

2000 - 2002 Pathogenesis of HHV-6 infection against the complication after organ transplantation

1999 - 2001 Analysis of pathogenesis of primary infection and reactivation of HHV-6

1998 - 2000 Comprehensive study for control of human herpes virus infection after organ transplantation

1997 - 1999 Comprehensive study for pathogenesis, prophylaxis and treatment of varicella in mouse model

1997 - 1998 小児生体肝移植後のHHV-6、HHV-7感染の解析

1997 - 1998 宿主拒絶反応に及ぼすヘルペスウイルス感染の影響:マウス臓器移植モデルによる解析

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Papers (435)：

Mao Asakura, Yasuaki Mizutani, Sayuri Shima, Yoshiki Kawamura, Akihiro Ueda, Mizuki Ito, Tatsuro Mutoh, Tetsushi Yoshikawa, Hirohisa Watanabe. Elevated cerebrospinal fluid IgG index in herpes simplex encephalitis post-HSV-1 clearance: A preliminary study. Journal of medical virology. 2024. 96. 8. e29850
Kei Kozawa, Yuki Higashimoto, Yoshiki Kawamura, Hiroki Miura, Fumihiko Hattori, Yuka Mihara, Hidetaka Nakai, Naoko Nishimura, Takao Ozaki, Masaru Ihira, et al. Temporal patterns of asymptomatic SARS-CoV-2 infection among pediatric population in Japan: A 3-year analysis. Journal of medical virology. 2024. 96. 8. e29847
Yoshinori Ito, Ichiro Morioka, Naoto Takahashi, Kazumichi Fujioka, Kiyonori Miura, Hiroyuki Moriuchi, Noriko Morimoto, Tetsushi Yoshikawa, Mariko Ashina, Shinya Abe, et al. Clinical Practice Guidelines for the Management of Congenital Cytomegalovirus Infection in Japan 2023: Executive Summary. The Pediatric infectious disease journal. 2024
Saori Fukuda, Masanori Kugita, Kanako Kumamoto, Yuki Akari, Yuki Higashimoto, Shizuko Nagao, Takayuki Murata, Tetsushi Yoshikawa, Koki Taniguchi, Satoshi Komoto. Generation of Recombinant Authentic Live Attenuated Human Rotavirus Vaccine Strain RIX4414 (Rotarix®) from Cloned cDNAs Using Reverse Genetics. Viruses. 2024. 16. 8
丸谷健太朗, 上野雄司, 川上沙織, 平良遼志, 赤峰哲, 鳥尾倫子, 小野山さがの, 古野憲司, 安部朋子, 河村吉紀, et al. FilmArray髄膜炎/脳炎パネル(FA-M/E)でHHV-6陽性の臨床的意義についての検討. 脳と発達. 2024. 56. Suppl. S198-S198

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MISC (333)：

近藤宏樹, 多屋馨子, 天羽清子, 乾あやの, 笠原群生, 齋藤昭彦, 鈴木光幸, 田中孝明, 塚原宏一, 津川毅, et al. COVID-19パンデミック期の小児の急性肝炎原因不明の小児急性肝炎対策ワーキンググループのこれまでの活動と調査結果に関する報告. 日本小児科学会雑誌. 2024. 128. 2. 165-165
向野文貴, 松重武志, 飯橋直太, 岡田裕介, 飯田恵庸, 岡崎史子, 福田謙, 河村吉紀, 三浦浩樹, 吉川哲史, et al. A girl treated for HHV-6 encephalitis who was later diagnosed as having inherited chromosomally integrated HHV-6. 日本小児科学会雑誌. 2024. 128. 2
近藤宏樹, 多屋馨子, 天羽清子, 乾あやの, 笠原群生, 鈴木光幸, 田中孝明, 津川毅, 別所一彦, 保科隆之, et al. 原因不明の小児急性肝炎に関する実態調査(一次調査)報告書. 日本小児科学会雑誌. 2023. 127. 7. 1033-1038
近藤宏樹, 多屋馨子, 天羽清子, 乾あやの, 笠原群生, 鈴木光幸, 田中孝明, 津川毅, 別所一彦, 保科隆之, et al. 原因不明の小児急性肝炎に関する実態調査(一次調査)報告書. 日本小児科学会雑誌. 2023. 127. 7. 1033-1038
安田泰明, 中島葉子, 須藤湧太, 横井克幸, 吉川哲史, 伊藤哲哉. 尿素サイクル異常症の慢性期管理における血漿アミノ酸分析の検討. 日本先天代謝異常学会雑誌. 2023. 39

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Books (9)：

小児内科
2013
医薬ジャーナル
2013
小児の発熱A to Z
2012
新編ウイルスの今日的意味
2012
小児保健研究
2012

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Lectures and oral presentations (17)：

ワクチンの必要性と課題-水痘-
(第117回日本小児科学会 2014)
岡株水痘ワクチンによる水痘の感染制御
(第55回日本臨床ウイルス学会 2014)
病原体検出検査法とそのピットフォール
(第54回日本臨床ウイルス学会 2013)
ロタウイルス感染症の病態とワクチンによる予防について
(第53回日本臨床ウイルス学会 2012)
水痘ワクチン定期接種化に向けて・その効果と導入に向けた試み
(第44回日本小児感染症学会 2012)

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Professional career (1)：

臓器移植後のhuman herpesvirus 6 (藤田保健衛生大学)

Association Membership(s) (4)：

日本ワクチン学会 , 日本ウイルス学会 , 日本小児感染症学会 , 日本小児科学会

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