Rchr

J-GLOBAL ID：200901031349276519 Update date: Jul. 25, 2024

Hashimoto Takashi

ハシモトタカシ | Hashimoto Takashi

Affiliation and department：
Job title： Specially-Appointed Professor
Homepage URL (1)： https://www.omu.ac.jp/med/derma/

Research field (3)： Dermatology , Immunology , Medical biochemistry

Research keywords (3)：皮膚免疫学皮膚生化学 , skin biochemistry , Skin immunology

Research theme for competitive and other funds (62)：

2021 - 2024 多角的な研究方法による抗ラミニンガンマ1類天疱瘡の自己抗体の特異性と病原性の検討
2018 - 2021 The study of process and pathogenesis of immunoglobulin class switch in various autoimmune bullous diseases
2016 - 2020 Pathological study for new treatment using iPS cells derived from patients with atopic dermatitis
2016 - 2019 Determination of the functions of specific CD44 proteins in human skin and epidermis and their relation to skin diseases, cancer and autoimmunity
2013 - 2016 Clinical and immunological profiles of anti-BP230-type bullous pemphigoid

2013 - 2016 Serological and genetical study in Japanese dermatitis herpetiformis

2014 - 2015 腫瘍随伴性天疱瘡における閉塞性細気管支炎の発生機序の解明

2012 - 2015 ChIP-seq analysis of human MC1R signaling

2012 - 2015 Establishment of extramammary Paget's disease derived cell line: Experimental research of the effect of anti-androgen reagents on extramammary Paget's disease cell line.

2015 - 2015 皮膚自己抗原解析におけるmTECの新規転写因子の同定と中枢性免疫寛容機序の解明

2013 - 2014 アトピー性皮膚炎と遺伝:全エクソンシーケンスによる新規疾患感受性遺伝子の探索

2012 - 2013 Analysis of mechanisms for blister formation via autoantibodies-mediated interference of adhesion system of laminins and integrins

2011 - 2013 Analysis of unknown autoantigen for autoimmune bullous disease.

2009 - 2010 抗ラミニンγ1類天疱瘡の病態の直接証明

2008 - 2010 Participation of plakin family proteons in differentiation of keratinocytes : Fundamental study to new cancer therapy

2008 - 2010 Analysis of unidentified autoantigens for IEN type IgA pemphigus and anti-p200 pemphigoid

2005 - 2007 抗基底膜部自己免疫性水疱症の反応性に対するヘミデスモソーム蛋白プロセシングの関与

2002 - 2005 Immunological and epidemiological studies on the endemic pemphigus foliaceus seen in developing areas of South America Columbia

2002 - 2005 Pathogenic analysis for autoimmune and hereditary skin diseases due to abnormality of desmosomes

2003 - 2004 FUNCTIONAL ANALYSIS OF PLAKIN FAMILY PROTEINS

2003 - 2004 The study of substance P effects on Langerhans cells

2001 - 2003 The establishment of diagnostic system for all the autoimmune bullous disease using various biochemical techniques

2001 - 2002 バキュロウイルス発現蛋白のELISA法を用いた抗デスモコリン自己抗体の研究

2000 - 2001 ケラチンおよびデスモソーム蛋白異常に伴う先天性皮膚疾患の遺伝子変異解析

2000 - 2001 線状1gA水疱性皮膚症と1gA天疱瘡の動物モデルの作成

1999 - 2001 Development of knockout mouse of desmoyokin(AHNAK)and analysis of its functio

1999 - 2000 Analysis of autoimmune bullous diseases using recombinant proteins of BP230 and BP180

1998 - 1999 Biological investigation of Paget cells using immortalized Paget cells

1998 - 1999 Development of novel therapy against bullous diseases

1997 - 1999 Establishment of molecular biological tests for the diagnosis of various autoimmune bullous skin dermatosis with auto-basement manbrane zone autoantibodies

1996 - 1998 Mutation detection and DNA based prenatal diagnosis in Japanese patients with epidermolysis bullosa

1996 - 1997 Molecular biological study of the role of various desmosomal component proteins on inflammatory and hyperproliferating skin diseases.

1995 - 1996 Development of a novel diagnostic tool using recombinant pemphigus antigens with the proper native conformation.

1995 - 1996 Molecular basis of Japanese with Herlitz epidermolysis bullosa and Its application to the diagnosis and prenatal diagnosis

1995 - 1995 デスモヨ-キンの角化細胞間接着における機能の解析と皮膚疾患への関与の検討

1993 - 1995 Clarification of pathogenesis in pemphigus : Establishment of new techniques for diagnosis.

1994 - 1994 角化細胞間接着におけるデスモヨ-キンの機能の解析

1993 - 1994 Basic studies for the pathogenesis and diagnosis of the autoimmune bullous diseases

1992 - 1993 Establishment of prenatal diagnosis of epidermolysis bullosa in Japan

1992 - 1993 デスモソームカドヘリン群cDNAを用いた天疱瘡抗原の解析

1991 - 1992 Application of up-to date immunoelectron microscopy for the study of pathogenesis of skin blistering disease.

1990 - 1991 Detection of antigen epitope for bullous pemphigois antigenic protein and the development of autoantibody detection using synthetic polypeptide

1990 - 1991 Cloning of total cDNA for desmoplakin and its molecular analysis and chromosomal mapping

1990 - 1991 Basic studies for the diagnosis of bullous diseases having pathologic changes at the basement membrane zone

1989 - 1989 クロ-ン化デスモグラキンcDNAの解析と生物学的応用の検討

1988 - 1988 デスモゾーム構成蛋白遺伝子のクローニング

1986 - 1987 デスモゾーム蛋白と天疱瘡の抗原物質の関連に関する研究

1985 - 1986 Role of cutaneous infiltrates in pemphigoid and pemphigus.

1976 - Study on function of desmoyokin

1976 - Study on desmosomal component proteins

1976 - Study on autoantigens in autoimmuno blistering skin disease

遺伝性皮膚疾患

皮膚の感染と免疫

毛の生物学

表皮角化細胞の構造と機能

デスモヨーキンの機能の研究

デスモソーム構成蛋白の研究

自己免疫性水疱症の抗原物質の研究

Hereditary diseases of the skin

Infection and immunology of the skin

Hair biology

Structure and function of Keratinocyte

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Papers (370)：

Takashi Hashimoto, Hua Qian, Norito Ishii, Takekuni Nakama, Chiharu Tateishi, Daisuke Tsuruta, Xiaoguang Li. Classification and Antigen Molecules of Autoimmune Bullous Diseases. Biomolecules. 2023. 13. 4
Mai Hamaguchi, Naoki Oiso, Masako Sato, Akira Kawada, Chiharu Tateishi, Takashi Hashimoto, Daisuke Tsuruta, Atsushi Ohtsuka. Epidermolysis bullosa acquisita with concomitant autoantibodies to α3 subunit of laminin 332. The Journal of Dermatology. 2022. 50. 5
石井芙美, 三宅智子, 杉本佐江子, 川上佳夫, 松田真由子, 森田安理, 山崎修, 石井文人, 泉健太郎, 西江渉, et al. 全長BP180 ELISA法にて診断し得た水疱性類天疱瘡の1例. 皮膚科の臨床. 2022. 64. 10. 1675-1679
岩津理世, 佐藤雅子, 加藤麻衣子, 柳原茂人, 大磯直毅, 立石千晴, 橋本隆, 鶴田大輔, 川田暁, 大塚篤司. 抗ラミニンγ1類天疱瘡と抗ラミニン332型粘膜類天疱瘡を合併した1例. 皮膚の科学. 2022. 21. 2. 126-132
Shirin Emtenani, Saeedeh Ghorbanalipoor, Sarah Mayer-Hain, Khalaf Kridin, Lars Komorowski, Christian Probst, Takashi Hashimoto, Hendri H. Pas, Kaja Męcińska-Jundziłł, Rafał Czajkowski, et al. Pathogenic Activation and Therapeutic Blockage of FcαR-Expressing Polymorphonuclear Leukocytes in IgA Pemphigus. Journal of Investigative Dermatology. 2021. 141. 12. 2820-2828

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MISC (907)：

石井芙美, 三宅智子, 杉本佐江子, 川上佳夫, 松田真由子, 森田安理, 山崎修, 石井文人, 泉健太郎, 西江渉, et al. 全長BP180 ELISA法にて診断し得た水疱性類天疱瘡の1例. 皮膚科の臨床. 2022. 64. 10. 1675-1679
後藤芽以子, 廣保翔, 大霜智子, 峯麻子, 林大輔, 橋本隆, 鶴田大輔. Brunsting-Perry型類天疱瘡様後天性表皮水疱症の1例. 日本皮膚科学会雑誌. 2022. 132. 1. 85-85
Seung Yeon Lee, Ki Hun Lee, Norito Ishii, Takashi Hashimoto, Jong Hoon Kim, Chil Hwan Oh, Kun Park. Rare case of bullous pemphigoid occurring on atrophic centers of disseminated superficial porokeratosis lesions. Journal of Dermatology. 2021. 48. 11. e530-e531
Hiromichi Kawashima, Riho Kageji, Yasutoshi Hida, Tetsuya Goto, Norito Ishii, Takashi Hashimoto. Case of pemphigoid with antibodies to BP180 C-terminal domain and α3 subunit of laminin-332 associated with chronic graft-versus-host disease. Journal of Dermatology. 2021. 48. 9. e447-e448
Takahiro Hamada, Norito Ishii, Hiroshi Koga, Kwesi Teye, Shuji Nagata, Atsushi Matsuo, Takamitsu Okada, Takashi Hashimoto, Takekuni Nakama. Ulnar deviation with massive palmar keratoderma in epidermolytic ichthyosis. Journal of Dermatology. 2021. 48. 9. e456-e457

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Works (10)：

Establishment of desmocollin EUSA
1999 - 2001
Knockout mouse of desmoyokin
2000 -
Identification of keratin mutation
1999 -
ヘイリーヘイリー病遺伝子変異の同定
魚鱗癬遺伝子変異の同定

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Education (1)：

Keio University School of Medicine

Professional career (1)：

(BLANK) (Keio University)

Work history (11)：

2017/04 - 現在 Graduate School of Medicine, Osaka Metropolitan University Dermatology Specially appointed Professor
2017/04 - 現在 Graduate School of Medicine, Osaka Metropolitan University Dermatology Specially appointed Professor
2010/04 - 2017/03 Kurume University Institute of Cutaneous Cell Biology
2010/04 - 2017/03 久留米大学皮膚細胞生物学研究所
1996 - 2014 Kurume University School of Medicine

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Committee career (2)：

日本研究皮膚科学会理事
日本皮膚科学会理事

Awards (2)：

1996 - 第一回慶應義塾大学医学振興坂口基金奨励賞
1994 - 平成6年度慶應義塾大学・三四会北里賞

Association Membership(s) (11)：

American Academy of Dermatology , Society for Investigative Dermatology , European Society of Dermatological Research , 水疱症研究会 , 表皮細胞研究会 , 日本細胞生物学会 , 日本臨床皮膚科学会 , 日本研究皮膚科学会 , 日本皮膚科学会西部支部 , 日本皮膚科学会東京支部 , 日本皮膚科学会

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