Rchr

J-GLOBAL ID：200901031645169949 Update date: Sep. 29, 2025

Ishii Naoto

イシイナオト | Ishii Naoto

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.immunol.med.tohoku.ac.jp/

Research field (3)： Experimental pathology , Fetal medicine/Pediatrics , Immunology

Research keywords (4)：アレルギー , Immunodeficiency , Autoimmunity , T cell immunity

Research theme for competitive and other funds (55)：

2023 - 2026 IL-33-ILC2系による抗腫瘍効果の作用機序の解明
2023 - 2026 Regulation of T cell immune responses by supersulfide
2023 - 2025 Development of a method for activation of costimulatory immune receptors by using their corresponding multimerized ligands
2022 - 2025 新たな自己反応性T細胞の恒常性維持機構ならびに生理的・病理的意義の解明
2022 - 2025 新たな自己反応性T細胞の恒常性維持機構ならびに生理的・病理的意義の解明

2022 - 2024 Developing a novel therapeutic strategy to infectious disease based on innate immune function of T lymphocytes

2020 - 2023 Regulation of allergic and autoimmune responses by ILC2-T cell interaction

2020 - 2023 Proof of a novel gene underlying B lymphocyte deficiency using genome-edited mice

2018 - 2021 Characterization of multifunctional roles of TRAF5 in pro-inflammatory cytokine receptor signaling

2017 - 2020 GITR signaling regulates ILC2 function

2016 - 2019 Transmission dynamics of Respiratory Syncytial Virus and Establishing New Control Measures

2016 - 2018 Roles for TNFR superfamily molecules in regulation of ILC function

2015 - 2018 Mechanism of sublingual immune tolerance induction by cross-talking with gut mucosal immunity

2015 - 2018 Identification and analysis of the niches for helper memory T cells

2015 - 2018 Regulation of inflammatory cytokine signaling by TRAF5

2014 - 2016 Pouchitis develops due to change of sodium concentration

2013 - 2015 Development of novel immunotherapy against malignant glioma

2012 - 2015 Roles of TRAF5 in the lineage commitment of helper T cell subsets

2012 - 2015 Development of a highly efficient gene targeting strategy using adenovirus-mediated delivery of donor DNA and artificial nucleases

2012 - 2015 Roles of OX40 and IL-7 in homeostasis of memory T cells

2012 - 2014 Development of a novel human leukemia model using humanized mice

2009 - 2011 T-cell costimulation-mediated regulation of mucosal inflammation

2007 - 2011 Mechanisms and their regulation of autoimmune disorders

2007 - 2009 Leukemogenesis due to insertional mutagenesis-a NOG mouse model-

2008 - 2008 小胞輸送分子Hrsを介する細胞老化とがん細胞悪性形質の制御

2007 - 2008 脱ユビキチン化酵素AMSH、AMSH-LPによるタンパク質分解機構の解明

2006 - 2007 肺高血圧症の分子機構における免疫系細胞活性化分子の役割の解明

2006 - 2007 Regulation of effector T cells that mediate inflammatory responses

2006 - 2007 T細胞免疫記憶に関する細胞外環境の解析

2006 - 2007 炎症性腸疾患感受性遺伝子の同定と機能解析

2005 - 2006 Development of therapy method target against OX40 signal for allergy or autoimmune diseases

2005 - 2006 A unique CD204^+ subpopulation of dendritic cells in NOD mice

2005 - 2006 CD4陽性記憶T細胞恒常性維持におけるOX40の役割

2004 - 2006 Functional and therapeutic study on inhibitory genes associated with collagen diseases

2002 - 2006 Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions

2005 - 2005 成人T細胞白血病における白血病細胞起源に関する研究

2001 - 2005 Regulation of infectious immunity by the OX40-0X4OL system

2004 - 2004 間質性肺炎および炎症性腸疾患責任遺伝子の同定

2003 - 2004 Immunological tolerance regulated by the interaction between T cell and antigen-presenting cell

2003 - 2003 T細胞補助刺激分子を介した調節性T細胞機能制御

2003 - 2003 がん免疫における生体内免疫寛容制御機構の解明

2003 - 2003 間質性肺炎および炎症性腸疾患感受性遺伝子の同定

2001 - 2002 OX40-OX40リガンド系を介した免疫制御

2001 - 2001 腫瘍免疫におけるOX40-OX40L系の機能解析

2001 - 2001 アレルギー免疫疾患モデルマウスを用いた発症要因に関わる遺伝背景の解析

2000 - 2001 Regulation of autoimmune diseases by OX40-OX40L interact

2000 - 2001 Cytokine receptor γc chain/Jak3 mediated signal transduction and analysis of immunodeficiecy by dysfunction of the γc chain/Jak3

2000 - 2001 Analysis of transgenic mice expressing human parvovirus non-stractual (NS1) protein

2000 - 2000 アレルギー免疫疾患モデルマウスを用いた発症要因に関わる遺伝背景の解析

2000 - 2000 新規シグナル分子"AMSH"の遺伝子欠損による脳神経特異的なアポトーシス誘導

1999 - 2000 Immune regulation by OX40/OX40 ligand system

1999 - 2000 Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling

1998 - 1999 Cytokine receptor γc chain mediated signal transduction and analysis of immunodeficiency by dysfunction of the γc chain

1998 - 1999 Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19

1998 - 1998 サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"

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Papers (165)：

Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao, et al. Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. Frontiers in Immunology. 2025. 16
Ziying Yang, Jing Li, Hideaki Watanabe, Feng Gao, Akihisa Kawajiri, Keita Koinuma, Kosuke Sato, Yuko Okuyama, Shunichi Tayama, Yoichiro Iwakura, et al. Naturally arising memory-phenotype CD4+ T lymphocytes give rise to multiple helper subsets to contribute to tumor immunity while inhibiting GVHD. Cancer Immunology Research. 2025
Akihisa Kawajiri, Jing Li, Keita Koinuma, Ziying Yang, Hye Jin Yoon, Jaeu Yi, Hiroyuki Nagashima, Minami Ishii, Feng Gao, Kosuke Sato, et al. Naturally arising memory-phenotype CD4 ⁺ T lymphocytes contain an undifferentiated population that can generate T _H 1, T _H 17, and T _reg cells. Science Advances. 2024. 10. 49
Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Naoto Ishii, Jinfang Zhu, Takeshi Kawabe. Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state. Frontiers in Immunology. 2024. 15
Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Nagito Shibui, Sayaka Ogawara, Yuta Tsutsui, Ayano Suzuki, Tomomi Wakaizumi, Aya Ito, Shimpei Matsuyama, et al. Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes. Cells. 2023. 12. 12

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MISC (120)：

新堀哲也, 田野島玲大, 笹原洋二, 佐藤篤, 入江正寛, 南條由佳, 舟山亮, 城田松之, 阿部太紀, 奥山祐子, et al. 幅広い臨床症状を呈したMECOM遺伝子変異を同定した2家系. 日本小児科学会雑誌. 2022. 126. 2. 230-230
河原永悟, 東充輝, 秋山晟, 藤森由夏, 大石真結, 渋井凪人, 川口甲介, 守田雅志, 奥山祐子, 石井直人, et al. Traf5-deficiency promotes T-helper cell type 1 development mediated by IL-27. 日本薬学会年会要旨集(Web). 2022. 142nd
守田匡伸, 山田充啓, 佐々木優作, 井田智章, 松永哲郎, 高田剛, 渡部聡, 稲葉謙次, 石井直人, 杉浦久敏, et al. T細胞受容体(TCR)/CD3複合体を標的とした超硫黄分子による免疫応答制御. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-890]
河原永悟, 藤森由夏, 大石真結, 川口甲介, 守田雅志, 奥山祐子, 石井直人, 宗孝紀. Elucidation of regulatory mechanisms of IL-27 receptor signaling mediated by TRAF5 in CD4⁺ T cells. 日本薬学会年会要旨集(Web). 2021. 141st
Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, et al. Author Correction: Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state (Nature Communications, (2020), 11, 1, (3366), 10.1038/s41467-020-17136-1). Nature Communications. 2020. 11. 1

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Books (21)：

サイトカイン・増殖因子用語ライブラリー
羊土社 2005
サイトカイン・増殖因子
羊土社 2005
サイトカイン・増殖因子、用語ライブラリー
羊土社 2005
サイトカイン・増殖因子用語ライブラリー
羊土社 2005
免疫2003
中山書店 2003

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Education (2)：

- 1995 Tohoku University Graduate School, Division of Medicine
- 1989 Tohoku University Faculty of Medicine

Professional career (1)：

博士(医学) (Tohoku University)

Committee career (7)：

2014/10 - 現在日本学術会議連携会員
2009/10 - 現在日本免疫学会評議員
2003/04 - 現在日本細菌学会東北支部会評議員
2018/04 - 2022/03 日本学術振興会・学術システム研究センター専門研究員
2014/06 - 2018/05 秋田県秋田県立高校学術顧問

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Awards (2)：

2004/01 - 宮城県医師会平成15年度宮城県医師会医学奨励賞
2004/01 - 東北大学医学部平成15年度東北大学医学部奨学賞金賞

Association Membership(s) (7)：

American association of immnologists , THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY , THE JAPANESE CANCER ASSOCIATION , JAPANESE SOCIETY OF ALLERGOLOGY , JAPAN PEDIATRIC SOCIETY , THE JAPANESE SOCIETY FOR IMMUNOLOGY , JAPANESE SOCIETY FOR BACTERIOLOGY

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