Research field (8)：
Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Healthcare management, medical sociology
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Pathobiochemistry
, Anesthesiology
, Clinical pharmacy
2020 - 2023 Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
2020 - 2023 Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary species
2019 - 2022 Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal models
2017 - 2020 Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
2017 - 2020 Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver mice
2016 - 2019 Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal models
2013 - 2018 マーモセットシトクロムP450の網羅的解析
2015 - 2017 The functional chacterization of marmoset cytochrome P450 2C enzymes
2014 - 2017 Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to Bioactivation
2013 - 2016 Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
2012 - 2015 Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450
2012 - 2015 The most suitable administration of antidepressive drug to avoid risk of side effects in patient
2011 - 2013 Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXR
2009 - 2011 Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450
2007 - 2008 Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.
2005 - 2007 Molecular mechanism of chemical-induced toxicity in fetal livers
2003 - 2005 Basic Research for Individualized Medicine
2003 - 2004 Molecular Mechanisms of Toxic Expression Induced by Endocrine Disruptors via AHR
2001 - 2002 In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.
2000 - 2002 CYP2A6のpharmacogenomics的研究
2000 - 2002 Genetic oncological and molecular epidemiological research on development and progression of the biliary tract cancer in Asia
2000 - 2002 Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.
2000 - 2001 Investigation and evaluation of genetic polymorphisms of drug metabolizing
1999 - 2000 PREDICTION OF DRUG DISPOSITION BY HUMAN DRUG METABOLIZING ENZYMES
Enzymology of polymorphic cytochrome P450 and flavin-containing monooxygenase
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Papers (697)：
Yasuhiro Uno, Miaki Makiguchi, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Makiko Shimizu, Hiroshi Yamazaki. Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2024. 277
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole. Drug metabolism and disposition: the biological fate of chemicals. 2024. 52. 3. 266-273
Koichiro Adachi, Makiko Shimizu, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki. Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances. The Journal of toxicological sciences. 2024. 49. 4. 127-137
Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Makiko Shimizu, Hiroshi Yamazaki. Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database. Biological & pharmaceutical bulletin. 2024. 47. 3. 635-640
Yasuhiro Uno, Osamu Yamato, Hiroshi Yamazaki. Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans. Drug Metabolism and Pharmacokinetics. 2024. 101002-101002
清水万紀子, 菱沼英史, 巻口美晶, 齋藤さかえ, 平塚真弘, 平塚真弘, 山崎浩史. New flavin-containing monooxygenase 3 variants from updated database in Tohoku Medical Megabank Organization. 日本薬学会年会要旨集(Web). 2023. 143rd
清水万紀子, 菱沼英史, 巻口美晶, 齋藤さかえ, 平塚真弘, 平塚真弘, 山崎浩史. New functional flavin-containing monooxygenase 3 variants from updated database in Tohoku Medical Megabank Organization. 日本薬学会年会要旨集(Web). 2023. 143rd
Yasuhiro Uno, Shotaro Uehara, Hiroshi Yamazaki. Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans. Biochemical Pharmacology. 2022. 197
清水万紀子, 巻口美晶, 中村友里愛, 菱沼英史, 菱沼英史, 齋藤さかえ, 齋藤さかえ, 平塚真弘, 平塚真弘, 平塚真弘, et al. Flavin-containing monooxygenase 3 variants from database in Tohoku Medical Megabank Organization. 日本薬学会年会要旨集(Web). 2022. 142nd
2023/02 - International Society of Study of Xenobiotics Asia Pacific Regional Scientific Achievement Award pecies Specificity and Selection of Animal Models for Drug Oxygenations Mediated by Polymorphic Human Enzymes
2014 - 日本薬物動態学会 学会賞
2008 - 日本薬物動態学会Fellow
2005 - 日本薬物動態学会奨励賞
2000 - 日本薬学会奨励賞
Association Membership(s) (4)：
日本臨床薬理学会
, International Society of Study of Xenobiotics
, 日本薬学会
, 日本薬物動態学会
