Rchr
J-GLOBAL ID：200901032447755154
Update date: Sep. 21, 2024
nakagawa shinichi
ナカガワ シンイチ | nakagawa shinichi
Affiliation and department：
Job title：
教授
Homepage URL (1)：
https://sites.google.com/rnabiol.com/home
Research field (2)：
Molecular biology
, Developmental biology
Research keywords (9)：
intrinsically disordered protein
, noncoding RNA
, 4.5SH
, splicing
, Genome Editing
, Neat1
, paraspeckle
, nuclear bodies
, 核スペックル
Research theme for competitive and other funds (20)：
- 2024 - 2029 Elucidation of the Mechanism of Action of srRNA Controlling Splicing and Identification of Novel srRNAs
- 2021 - 2026 Funtional analyses of non-domain RNAs using mutant mice
- 2021 - 2026 Management of non-domain biopolymer research group
- 2021 - 2026 Biology of Non-domain Biopolymer
- 2021 - 2024 超天然変性タンパク質の個体レベルでの生理機能解析
- 2018 - 2023 Biochemical approaches to understanding the reaction platforms of the piRNA pathway
- 2017 - 2022 Functional analyses of novel lncRNAs using reverse genetics
- 2015 - 2019 Support activities to promote international collaboration to accomplish the research on noncoding RNA neo-taxonomy
- 2014 - 2019 Functional analyses of physiological function of ncRNA according to the neo-taxonomy
- 2009 - 2014 Functional machinery for non-coding RNAs
- 2012 - 2012 Elucidation of molecular mechanisms controlling localization and metabolism of mRNAs via retrotransposon insertions
- 2011 - 2012 Analysis of regulatory mechanisms of epigenetic gene regulation by a complex of nuclear matrix protein and noncoding RNA
- 2009 - 2012 Chemical Genetics on Novel Functions of Splicing Factors
- 2009 - 2012 Genetic approaches to physiological functions of long noncoding RNA machinery
- 2007 - 2009 Elucidation of molecular mechanism that controls the maintenance of retinal stem cells
- 2005 - 2006 網膜の予定神経節細胞の核に局在するノンコーディングRNAの機能解析
- 2004 - 2006 Investigation of the mechanisms controlling formation of the laminated structures in the central nervous system
- 2005 - 2005 中枢神経系の層形成時に細胞タイプ特異的に発現する新規遺伝子の機能解析
- 2003 - 2004 中枢神経系の層形成過程においてニューロンが特定の層を認識する分子メカニズムの研究
- 2001 - 2003 Analysis of the laminated structures in the central nervous system
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Papers (128)：
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Shuntaro Inoue, Yume Masaki, Shinichi Nakagawa, Saori Yokoi. An evolutionarily distinct Hmgn2 variant influences shape recognition in Medaka Fish. Communications biology. 2024. 7. 1. 973-973
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Hikaru Toya, Yuko Okamatsu-Ogura, Saori Yokoi, Misuzu Kurihara, Mari Mito, Shintaro Iwasaki, Tetsuro Hirose, Shinichi Nakagawa. The Essential Role of Architectural Noncoding RNA Neat1 in Cold-Induced Beige Adipocyte Differentiation in Mice. RNA (New York, N.Y.). 2024
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Sikandar Azam, Kaitlyn S. Armijo, Chi G. Weindel, Morgan J. Chapman, Alice Devigne, Shinichi Nakagawa, Tetsuro Hirose, Susan Carpenter, Robert O. Watson, Kristin L. Patrick. The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle. Proceedings of the National Academy of Sciences. 2024. 121. 9
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Rei Yoshimoto, Yuta Nakayama, Ikuko Nomura, Ikuko Yamamoto, Yumeka Nakagawa, Shigeyuki Tanaka, Misuzu Kurihara, Yu Suzuki, Takehiko Kobayashi, Hiroko Kozuka-Hata, et al. 4.5SH RNA counteracts deleterious exonization of SINE B1 in mice. Molecular cell. 2023. 83. 24. 4479-4493
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Hiro Takakuwa, Tomohiro Yamazaki, Sylvie Souquere, Shungo Adachi, Hyura Yoshino, Naoko Fujiwara, Tetsuya Yamamoto, Tohru Natsume, Shinichi Nakagawa, Gerard Pierron, et al. Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles. Nature cell biology. 2023. 25. 11. 1664-1675
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MISC (105)：
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高桑央, 高桑央, 山崎智弘, SOUQUERE Sylvie, 足達俊吾, 藤原奈央子, 吉野彪羅, 山本哲也, 中川真一, 村上正晃, et al. Shell protein composition specified by NEAT1 domains dictates the paraspeckle segregation from nuclear speckles. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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横井佐織, 水戸麻里, 岩崎信太郎, 中川真一. Analysis of physiological funtions of malat1 in medaka fish. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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田中豪, 成瀬清, 郷康広, 辰本将司, 豊田敦, 勝村啓史, 中川真一, 横井佐織. メダカをモデルとした行動に関わる性格の分子神経基盤解析. 日本神経化学会大会抄録集(Web). 2022. 65th
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大峽 咲希, 中川 真一, 米田 宏. 【相分離 メカニズムと疾患"膜のないオルガネラ"はいかに機能するか?神経変性疾患・ウイルス感染とどう関わるか?】(第2章)相分離と細胞内構造 核内の非膜オルガネラ Cajal bodyの多機能性と柔軟性の包括的理解. 実験医学. 2021. 39. 10. 1509-1514
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中川 真一, 大峽 咲希, 米田 宏. 細胞内ティール組織化:マルチバレント相互作用と相分離が織りなす細胞内プロセスの理解 ティール相互作用によって作られる核内非膜オルガネラの形成機構. 日本細胞生物学会大会講演要旨集. 2020. 72回. W2-4
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Books (1)：
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ノンコーディングRNAテキストブック : 最新の医学・創薬研究、方法論とマイルストーン論文200報
羊土社 2015 ISBN:9784758103510
Lectures and oral presentations (52)：
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Preferential association of prion-like-domain-containing RNA binding proteins to functional lncRNA candidates
(2018)
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Prediction of functional lncRNAs using UPA-seq
(CSHL Asia 2018)
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UPA-Seq:UVへの感受性を利用した機能性lncRNAの同定
(日本RNA学会年会要旨集 2018)
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Attempts towards identification of novel functional lncRNAs
(EMBO workshop 2018)
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Towards Identification of Novel Functional Long noncoding RNAs
(Kumamoto Key Forum 2018)
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Professional career (1)：
Work history (7)：
- 2016/05 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences Professor
- 2010/04 - 2016/04 RIKEN Associate Chief Scientist
- 2005/04 - 2010/03 RIKEN Initiative Researcher
- 2002/04 - 2005/03 RIKEN CDB Researcher
- 2000/04 - 2002/03 University of Kyoto Assistant Professor
- 1998/04 - 2000/03 University of Cambridge Postdoctral Fellow
- 1995/04 - 1998/03 Kyoto University Deparment of Biophysics, Graduate School of Science
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Association Membership(s) (3)：
日本分子生物学会
, 日本RNA学会
, 日本発生生物学会
