Rchr

J-GLOBAL ID：200901032950554360 Update date: Dec. 18, 2024

Akao Yukihiro

アカオユキヒロ | Akao Yukihiro

Affiliation and department：
Job title：特任教授
Other affiliations (3)：

大阪医科大学医学部客員教授
連合創薬医療情報研究科特任教授
工学研究科教授

Homepage URL (1)： http://www.souyaku.gifu-u.ac.jp/

Research field (2)： Experimental pathology , Medical biochemistry

Research keywords (3)： RCK/P54 RNA helicase in cancer , phytochemicals in cancer prevention , microRNAs in humancancers

Research theme for competitive and other funds (36)：

2019 - 2022 Mechanism of Exosome Production by Heterotrimeric G Protein Signaling
2018 - 2021 Realization of microRNA drug discovery, overcoming intractable cancer through medicine-engineering-pharmacy collaboration
2016 - 2019 The elucidation of biliary and pancreatic tumor's pathobiology through the functional analysis of novel Warburg effect-associated gene PTBP1
2016 - 2019 Investigation of extracellular vesicles as novel biomarker in 4 type gastric cancer patients
2018 - 2019 がん特異的エネルギー代謝を標的にしたRNA創薬

2016 - 2019 難治がん治療に向けたユニットPIC型核酸医療送達システムの研究開発-RNA医薬

2015 - 2018 Development of exosome including osteogenesis-related microRNA

2015 - 2018 Identification of the Warburg effect-associated microRNAs and those targeting genes and clinical application of those

2016 - 2017 ヒトメラノーマに対するマイクロRNA-205のRNA創薬への試行

2016 - 2017 先制医療の実践に資するバイオマーカーの同定とデザイナーフードの開発

2014 - 2016 The role of exosome derived melanoma cells in tumor immunity

2013 - 2016 Mouse mammary carcinoma cell lines release microvesicles containing precurcer VEGF-C

2013 - 2016 Translational research toward drug discovery of leukemia

2012 - 2015 Therapeutic application of microRNA for canine oral malignant melanoma.

2011 - 2015 The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFs

2012 - 2015 分泌膜小胞を用いたRNA医療の試行

2012 - 2014 分泌膜小胞を用いたRNA医療の試行

2011 - 2013 Molecular mechanism of miR-143/145 down-regulation in cancer and disease

2008 - 2010 Role of miR-143 and -145 in carcinogenesis of colon cancer

2001 - 2006 Biologocal activity in polyphenol

2001 - 2006 ポリフェノールの生理活性

1991 - 2006 Tumor Biology

1991 - 2006 腫瘍医学

2004 - 2005 Human DEAD-box/RNA helicase rck/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cells

2004 - 2005 REGULATORY MECHANISM BY PHOSPHOLIPASE D IN OXIDANT-STRESS INDUCED SURVIVAL SIGNALING

2002 - 2003 RNAヘリカーゼと癌関連遺伝子の発現に関する機能解析と分子イメージング

2002 - 2003 CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL

2000 - 2001 THE RELATION OF VARIANT MLL GENE TO CELL DEATH AND UNRESPONSIVENESS TO CHEMOTHERAPY IN INFANTILE LEUKEKEMIA WITH 11q23 TRANSLOCATION

2000 - 2001 MECHNISM OF APOPTOSIS INDUCED BY MEMBRANE LIPID SYGNALING

1998 - 2001 Functional analysis of the new signal transduction enzyme PLD by the molecular genetic technique

1997 - 1998 Molecular diagnosis and theray of infantile acute leukemia carrying 11q23 translocations

1994 - 1995 Apoptosis in female genital organs-the relation between bcl-2 protein and hormone receptor

1994 - 1995 The role of Chromosome translocation-related genes on tumorigenecity in hematological malignancie

1992 - 1992 造血器腫瘍の新しい第11番染色体転座関連遺伝子の単離とその診断と予後判定への応用

1991 - 1991 造血器腫瘍の診断と予後判定に有用な新しい転座関連遺伝子

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Papers (363)：

Hirotaka Murase, Shingo Minatoguchi, Kazuki Heishima, Shinji Yasuda, Atsushi Satake, Ryo Yoshizumi, Hisaaki Komaki, Shinya Baba, Shinsuke Ojio, Toshiki Tanaka, et al. Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction. Heart and vessels. 2024
Soo Takasu, Risa Watanabe, Nobuhiko Sugito, Kohei Morikawa, Akio Iio, Yukihiro Esaka, Yukihiro Akao. Unveiling the vitamin E profile in rice bran extracellular vesicles: evaluation of extraction and preparation methods. Analytical Sciences. 2024
Jun Arima, Kohei Taniguchi, Nobuhiko Sugito, Kazuki Heishima, Yoshihisa Tokumaru, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Masa-Aki Shibata, Sang-Woong Lee, et al. Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation. Molecular Therapy - Nucleic Acids. 2023. 34. 102079-102079
Noriko Miyamoto, Nobuhiko Sugito, Yukio Kitade, Yukihiro Akao. Growth inhibition of RAS-mutated hematopoietic tumor cells using glucose-attached reversibly ionic oligonucleotide-based nanoparticles caging chemically modified microRNA143-3p. Journal of Drug Delivery Science and Technology. 2023. 88. 104902-104902
Kazuki Heishima, Nobuhiko Sugito, Chikara Abe, Akihiro Hirata, Hiroki Sakai, Yukihiro Akao. Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model. Molecular Therapy - Nucleic Acids. 2023. 33. 960-982

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MISC (105)：

平島一輝, 平島一輝, 吉川竜太郎, 赤尾幸博, 酒井洋樹, 森崇. MicroRNA drug and biomarker development exploiting human-canine homology in angiosarcoma and osteosarcoma. 日本癌学会学術総会抄録集(Web). 2022. 81st
中川義仁, 赤尾幸博, 村嶋健太郎, 小山恵司, 尾崎隼人, 大森崇史, 城代康貴, 前田晃平, 山田日向, 吉田大, et al. 大腸癌5-FU耐性に関与するmiR-31の標的遺伝子の探索. 日本消化器病学会雑誌. 2021. 118. 臨増総会. A379-A379
中川義仁, 赤尾幸博, 小山恵司, 尾崎隼人, 大森崇史, 城代康貴, 前田晃平, 山田日向, 吉田大, 寺田剛, et al. 大腸癌の5-FU耐性に関与するmiR-31の発現と機能の解析. 日本消化器病学会雑誌. 2020. 117. 臨増総会. A236-A236
谷口高平, 猪俣陽介, 杉戸信彦, 小村和正, 赤尾幸博, 内山和久. 非アルコール性脂肪肝炎におけるワールブルグ効果獲得の意義(The significance of Warburg effect found in nonalcoholic steatohepatitis). 日本癌学会総会記事. 2019. 78回. E-3007
中川義仁, 赤尾幸博, 尾崎隼人, 大森崇史, 城代康貴, 生野浩和, 前田晃平, 山田日向, 吉田大, 内堀遥, et al. 大腸癌5-FU耐性に関与するmicroRNAの探索と機能解析. 日本消化器病学会雑誌. 2019. 116. 臨増総会. A287-A287

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Patents (6)：

健康食品
癌細胞のアポトーシス誘導剤、その製造方法、それを有効成分とする抗癌剤、食品製剤及び化粧品
RNA修飾蛋白、蛋白合成促進剤、遺伝子治療薬及び癌治療薬
癌治療薬及び癌予防薬
癌治療薬

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Education (2)：

- 1978 Osaka Medical College Faculty of Medicine Medicine
- 1978 Osaka Medical College Faculty of Medicine Division of Medicine

Professional career (1)：

Doctor (Nagoya University)

Work history (16)：

2018/04 - 現在岐阜大学大学院連合創薬医療情報研究科特任教授
2009/04 - 2018/03 岐阜大学大学院連合創薬医療情報研究科教授
1998/04 - 2009/03 (財)岐阜県国際バイオ研究所遺伝子診断研究部部長
1997/04 - 1998/03 (財)岐阜県国際バイオ研究所遺伝子診断研究部副部長
1996 - 1998 Vice-Manager of Gifu International Institute of Biotechnology

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Committee career (2)：

2018/04 - 現在日本核酸医薬学会評議員
2017/06 - 2020/06 日本がん分子標的治療学会日本がん分子標的治療学会評議員

Awards (3)：

2004/09/15 - 日本白血病研究基金一般研究賞
1992 - Young Researcher Prize of Japanese Society of Hematology
1992 - 日本血液学会奨励賞

Association Membership(s) (10)：

日本核酸医薬学会 , 日本薬学会 , 日本分子生物学会 , 日本癌学会評議員 , 日本RNA学会 , 日本Cell Death学会 , American Association of Cancer Research , Japanese Society of Cancer Research , 米国癌学会 , 日本癌学会

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