Rchr

J-GLOBAL ID：200901033023282325 Update date: Jul. 31, 2022

Hirano Katsuya

ヒラノカツヤ | Hirano Katsuya

Affiliation and department：
Homepage URL (1)： http://www.med.kagawa-u.ac.jp/~cardiovasc-physiol

Research field (3)： Cardiology , Pharmacology , Physiology

Research keywords (8)：細胞内シグナル伝達 , 循環器 , 病態生理学 , 生理学 , Intracellular signal transduction , Cardiovascular system , Pathophysiology , Physiology

Research theme for competitive and other funds (28)：

2022 - 2027 血液凝固系の老化促進因子としての機能解明とその制御
2020 - 2023 凝固系を標的とした高齢者のインスリン抵抗性改善策の開発
2016 - 2019 トロンビン受容体を標的とする新規肺高血圧治療法の開発
2015 - 2018 プロテイナーゼ活性化型受容体1を介する血管機能障害の分子機構解明
2014 - 2016 トロンビン受容体を標的とする核心的脳血管攣縮治療法の開発

2012 - 2015 トロンビン受容体の活性制御異常の分子機構解明と新たな動脈硬化治療戦略の開発

2011 - 2013 肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用

2008 - 2010 Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.

2005 - 2006 Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions

2004 - 2005 Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.

2003 - 2004 Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications

2002 - 2003 内皮・平滑筋・繊維芽細胞の三次元共培養による血管構築を摸した血管モデルの作製

2002 - 2003 Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells

2001 - 2003 Molecular mechanisms of vasospasm : Intracellular signaling network underlying the Ca^<2+> of smooth muscle cells.

2002 - 2002 p27^新規分子種の同定とがん抑制因子としての機能解明

2001 - 2002 The assessment of the contractility of the proliferating vascular smooth muscle

2001 - 2002 The assessment of the contractility of the proliferating airway smooth muscle.

2001 - 2002 Development of a system for the continuous and simultaneous measurement of vascular intracellular signalings and metabolism

2001 - 2002 Elucidation of the Mechanism for the cell cycle regulation by a novel isoform of p27^ in the vascular cells

2001 - 2001 p27^新規分子種の同定とがん抑制因子としての機能解明

2000 - 2000 p27^新規分子種の同定とがん抑制因子としての機能解明

1999 - 2000 The role of the small GTP binding protein, rho, in the vascular smooth muscle.

1999 - 2000 Elucidation of the physiological role of myosin phosphatase in vascular endothelial cells and smooth muscle cells

1998 - 2000 Development of the optical system for continuous and multi-factorial monitoring of the intracellular signaling network in endothelial and smooth muscle cells in vascular strips.

1998 - 1999 血管内皮細胞カドヘリン複合体結合蛋白質の同定と生理機能の解明

1998 - 1998 血管平滑筋トロポミオシンの発現調節に関与するスプライシング因子の同定

1995 - 1998 Studies on molecular cell biology of the inhibition of coronary vasoconstriction and intimal thickening.

1997 - 1997 血管平滑筋細胞の分化に関与する平滑筋特異的スプライシング因子の同定

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Papers (191)：

Keizo Hiraishi, Feiyan Zhao, Lin Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano. Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis. Nutrients. 2022. 14. 3
Takanori Watanabe, Mariko Ishikawa, Kohtaro Abe, Tomohito Ishikawa, Satomi Imakiire, Kohei Masaki, Kazuya Hosokawa, Tomoko Fukuuchi, Kiyoko Kaneko, Toshio Ohtsubo, et al. Increased lung uric acid deteriorates pulmonary arterial hypertension. Journal of the American Heart Association. 2021. 10. 23
Keizo Hiraishi, Lin Hai Kurahara, Jianlin Feng, Aya Yamamura, Yuanyuan Cui, Eiji Yahiro, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Naoya Yokota, et al. Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Translational research : the journal of laboratory and clinical medicine. 2021. 233. 127-143
Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui. Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats. Journal of the American Heart Association. 2021. 10. 7. e019247
Haiyan Xu, Keizo Hiraishi, Lin-Hai Kurahara, Yuko Nakano-Narusawa, Xiaodong Li, Yaopeng Hu, Yoko Matsuda, Heping Zhang, Katsuya Hirano. Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model. NUTRIENTS. 2021. 13. 4

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MISC (210)：

Tetsuo Yamashita, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano. N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex. The Journal of Physiological Science. 2020. 70. Supplement 1. S137-S137
劉文華, 橋本剛, 山下哲生, 平野勝也. 血液凝固第XI因子の血管機能調節因子としての新たな機能の発見. 日本生理学雑誌(Web). 2019. 81. 2
平野勝也, 劉文華, 橋本剛, 山下哲生. 血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR₁を活性化し,細胞内Ca²⁺シグナルを発生させ,細胞遊走を促進する. 血管. 2019. 42. 1
山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也. 競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位. 日本農芸化学会中四国支部講演会講演要旨集(Web). 2018. 51st
劉文華, 橋本剛, 山下哲生, 平野勝也. 血液凝固第XI因子が引き起こす血管平滑筋細胞のCa²⁺シグナルの発生メカニズムの解明. 日本生理学雑誌(Web). 2018. 80. 3

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Patents (4)：

A therapeutic agent and a preventive agent for pulmonary hypertension comprising thrombin receptor antagonist as an active ingredient
プロテアソーム分解に抵抗性を示す新規p27Kip1分子種の核酸及びアミノ酸配列と同蛋白質の発現ベクター及び発現細胞
トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤
Nucleic acid and amino acid sequences of the degradation-resistant novel isoform of p27^Kip1, and expression plasmid and cells expressing the protein

Books (8)：

The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
Springer, Tokyo, Japan 2017
The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
Springer, Tokyo, Japan 2017
Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Humana Press, New York, 2013 ISBN:9781627030854
Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Humana Press, New York, 2013 ISBN:9781627030854
Idendification of hydrogen peroxide as an endothelium-derived hyperpolarization factor in mice.
Taylor & Francis, London, UK 2001

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Lectures and oral presentations (120)：

Novel role of coagulation factor XI as a regulator of vascular smooth muscle function.
(The 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) 2019)
Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells
(2019)
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する
(第48回日本心脈管作動物質学会総会 2019)
トロンビンによる内皮バリアー機能障害の初期事象におけるRho-Rhoキナーゼの役割
(第59回日本脈管学会総会 2018)
Novel function of coagulation factor XI as a regulator of vascular smooth muscle
(The 7th Chiang Mai University-Kagawa University Joint Symposium 2018 2018)

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Works (1)：

日本平滑筋学会ロゴマークデザイン
2014 - 現在

Education (2)：

1991 - Kyushu University
1979 - 1985 Kyushu University School of Medicine

Professional career (1)：

M. D., Ph.D. (Kyushu University)

Work history (9)：

2014/04 - Kagawa University, Faculty of Medicine Department of Cardiovascular Physiology Professor
2006/08 - 2014/03 Kyushu University, Graduate School of Medicine Department of Molecular Cardiology Associate Professor
2000/04 - 2006/07 Kyushu University, Graduate School of Medicine Department of Molecular Cardiology Assistant professor, Lecturer
1999/04 - 2000/03 Kyushu University, Graduate School of Medicine Department of Molecular Cardiology Assistant professor, Lecturer
1996/11 - 1999/03 Kyushu University, Faculty of Medicine Department of Molecular Cardiology Assistant professor, Lecturer

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Committee career (35)：

2020/03 - 現在 Physiological Society of Japan Vice President
2019/11 - 現在 Physiological Society of Japan member of the committee for meetings
2018/03 - 現在日本生理学会理事
2018/03 - 現在 Physiological Society of Japan Member of the committee for Awards
2016/08 - 現在 Japan Society of Smooth Muscle Research Board member

2016/08 - 現在 Japan Society of Smooth Muscle Research Member of the committee for Academic Program

2016/08 - 現在 Japan Society of Smooth Muscle Research Member of the committee for Publications

2016/08 - 現在 Japan Society of Smooth Muscle Research Member of the committee for Future planning

2016/04 - 現在香川大学医師会, 香川大学医師会理事, 理事

2015/02 - 現在 Japanese Society of Circulation Research Board member

2014/11 - 現在 Frontiers in Cardiovascular Medicine Frontiers in Cardiovascular Medicine, Review editor, Review editor

2014/06 - 現在 Japanese Pharmacological Society Editorial adviser of Journal of Pharmacological Sciences

2014 - 現在日本病態生理学会評議員

2013/10 - 現在 American Heart Association (米国心臓協会) Fellow of American Heart Association (FAHA)

2013/07 - 現在 International Society of Heart Research, Japan Section Council member

2013/04 - 現在日本生理学会評議員

2013 - 現在 Japan Society of Smooth Muscle Research Council member

2012/04 - 現在 Physiological Society of Japan Member of the committee for Publications and Public Relations

2010/11 - 現在 Frontiers in Integrative and Regenerative Pharmacology Frontiers in Integrative and Regenerative Pharmacology, Review editor

2010/02 - 現在日本心脈管作動物質学会評議員

1998/04 - 現在日本薬理学会学術評議員

2020/08 - 2021/08 Japan Society of Smooth Muscle Research The president of the 63rd Annual Meeting of Japan Society of Smooth Muscle Research

2019/08 - 2020/08 日本平滑筋学会第62回総会副会長

2016/11 - 2018/03 Physiological Society of Japan 95th Annual Meeting of the Physiological Society of Japan

2018/03 - 第95回日本生理学会大会, 第95回日本生理学会大会企画シンポジウム「平滑筋生理学から病態生理学へのトランスレーション(Translation from smooth muscle physiology to pathophysiology)」

2015/06 - 2017/06 Pulmonary Vascular Research Institute, Pulmonary Circulation, Editorial board

2014/02 - 2015/02 日本心脈管作動物質学会第44回年会長

2014/11 - 2014/11 日本生理学会第66回中国四国地方会世話人

2012/10 - 2014/10 日本薬理学会代議員

2012/06 - 2014/04 日本薬理学会 Journal of Pharmacological Sciences誌Editorial Advisor

2008/10 - 2010/10 日本薬理学会代議員

2008/06 - 2010/06 日本薬理学会 Journal of Pharmacological Sciences誌Editorial Advisor

2006/06 - 2008/06 日本薬理学会 Journal of Pharmacological Sciences誌Editorial Advisor

2004/10 - 2006/10 日本薬理学会代議員

1998/12 - 1999/12 International Society of Heart Research, Japan Section Secretary general, the 16th Annual Meeting of Japanese section of International Society of Heart Research

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Awards (9)：

2021/07 - American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology Arteriosclerosis, Thrombosis and Vascular Biology Top Reviewer of 2020 Award
2020/03 - Japanese Pharmacological Society Journal of Pharmacological Sciences Excellent Reviewer Award 2019
2017/03 - Japanese Pharmacological Society Journal of Pharmacological Sciences Excellent Reviewer Award 2016
2014/08 - Japan Society of Smooth Muscle Research Gold medal of logo mark design
2013 - 第29回スパズム・シンポジウム第4回優秀論文賞

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Association Membership(s) (11)：

日本循環薬理学会 , 日本病態生理学会 , 国際心臓研究学会 , 日本平滑筋学会 , 日本心脈管作動物質学会 , 日本生理学会 , 日本分子生物学会 , 日本内科学会 , 日本循環器学会 , American Heart Association , 日本薬理学会

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