J-GLOBAL ID:200901033023282325   Update date: Dec. 19, 2019

HIRANO Katsuya

ヒラノ カツヤ | HIRANO Katsuya
Affiliation and department:
Homepage URL  (1): http://www.med.kagawa-u.ac.jp/~cardiovasc-physiol
Research field  (4): General physiology ,  General pharmacology ,  Circulatory organs internal medicine ,  Applied pharmacology
Research keywords  (4): Physiology ,  Pathophysiology ,  Cardiovascular system ,  Intracellular signal transduction
Research theme for competitive and other funds  (26):
  • 2008 - 2010 Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.
  • 2005 - 2006 Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions
  • 2004 - 2005 Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.
  • 2003 - 2004 Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications
  • 2002 - 2003 Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells
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Papers (97):
  • Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y. Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body. Eur J Pharmacol. 2019. 857. 172405
  • Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y. COA-Cl prevented TGF-beta1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis. J Dermatol Sci. 2019. 94. 1. 205-212
  • Liu W, Hashimoto T, Yamashita T, Hirano K. Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1. Am J Physiol Cell Physiol. 2019. 316. 3. C377-C392
  • Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K. Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension. Cadiovasc Res. 2018. published online
  • YAMASHITA TETSUO, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, HIRANO Katsuya. Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Scientific Reports. 2018. 8. 1. 2427
Patents (2):
  • A therapeutic agent and a preventive agent for pulmonary hypertension comprising thrombin receptor antagonist as an active ingredient
  • Nucleic acid and amino acid sequences of the degradation-resistant novel isoform of p27Kip1, and expression plasmid and cells expressing the protein
Books (2):
  • Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
    Humana Press, New York, 2013 ISBN:978-1-62703-085-4
  • The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
    Springer, Tokyo, Japan 2017
Lectures and oral presentations  (87):
  • 大腸菌発現系を用いたApoptosis-inducing factor (AIF)と生体膜との相互作用の解析
    (日本生体エネルギー研究会 第40回討論会 2014)
  • Inhibition of increased thrombin receptor activity attenuated monocrotaline-induced pulmonary hypertension in rats
    (American Heart Association Scientific Session 2014 2014)
  • アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討
    (第66回日本生理学会中国四国地方会 2014)
  • Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity.
    (11th International Symposium on Resistant Artery 2014)
  • Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption
    (11th International Symposium on Resistant Artery 2014)
Education (1):
  • - 1985 Kyushu University Facultyof Medicine School of Medicine
Professional career (1):
  • M. D., Ph.D. (Kyushu University)
Work history (23):
  • 1985/06 - 1987/05 Kyushu University Hosptical Resident
  • 1985/06 - 1987/05 Kyushu University Intern
  • 1987/06 - 1990/10 Kyushu University, Graduate School of Medicine Research fellow (thesis work)
  • 1990/10 - 1993/03 University of Arizona Research Associate
  • 1990/10 - 1993/08 University of Arizona, Tucson, AZ, USA Research Associate
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Committee career (2):
  • 2016 - 2018 The Physiological Society of Japan The President of the 95th Annual Meeting
  • 1998 - Japanese Pharmacological Society Gakujutsu Hyogi-in
Awards (2):
  • 2017/03 - Japanese Pharmacological Society J Pharmacol Sci Best Reviewer Award 2016
  • 2002 - Young Investigator awards, 31th Scientific meeting for the Japanese Society for Circulation Research
Association Membership(s) (5):
Japanese Circulation Society ,  Japanese Biochemical Society ,  Japanese Society of Internal Medicine ,  Japanese Pharmacological Society ,  The Physiological Society of Japan
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