Research field (4)：
, General pharmacology
, Circulatory organs internal medicine
, Applied pharmacology
Research keywords (4)：
, Cardiovascular system
, Intracellular signal transduction
Research theme for competitive and other funds (26)：
2008 - 2010 Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.
2005 - 2006 Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions
2004 - 2005 Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.
2003 - 2004 Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications
2002 - 2003 Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells
2001 - 2003 Molecular mechanisms of vasospasm : Intracellular signaling network underlying the Ca^<2+> of smooth muscle cells.
2001 - 2002 The assessment of the contractility of the proliferating vascular smooth muscle
2001 - 2002 The assessment of the contractility of the proliferating airway smooth muscle.
2001 - 2002 Development of a system for the continuous and simultaneous measurement of vascular intracellular signalings and metabolism
2001 - 2002 Elucidation of the Mechanism for the cell cycle regulation by a novel isoform of p27^<Kip1> in the vascular cells
1999 - 2000 The role of the small GTP binding protein, rho, in the vascular smooth muscle.
1999 - 2000 Elucidation of the physiological role of myosin phosphatase in vascular endothelial cells and smooth muscle cells
1998 - 2000 Development of the optical system for continuous and multi-factorial monitoring of the intracellular signaling network in endothelial and smooth muscle cells in vascular strips.
1995 - 1998 Studies on molecular cell biology of the inhibition of coronary vasoconstriction and intimal thickening.
1987 - Study on the intracellular signal transduction regulating vascular tone
1997 - Study on the regulatory mechanism of the cell cycle in vascular cells
1990 - Regulation of vascular structure and function by protein phosphorylation
1996 - Molecular and cellular biology of proteinase-activated receptors and their roles in the vascular diseases
Development of protein transduction technique and its application to the cardiovascular medicine
2007 - Study on the molecular mechanism for the regulation of store-operated Ca influx and its role in the cardiovascular diseases
1996 - Vascular Physiology and pathophysiology of proteinase-activated receptors
2004 - Development of new therapeutic strategies for treatment of cerebral vasospasm
2011 - Development of new therapeutic strategies for treatment of pulmonary hypertension
1987 - Research on molecular mechanism of regulation of vascular tone
2006 - Molecular mechanism of regulation of store-operated calcium influx
2001 - Research on the regulatory mechanism for vascular permeability
Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y. Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body. Eur J Pharmacol. 2019. 857. 172405
Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y. COA-Cl prevented TGF-beta1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis. J Dermatol Sci. 2019. 94. 1. 205-212
Liu W, Hashimoto T, Yamashita T, Hirano K. Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1. Am J Physiol Cell Physiol. 2019. 316. 3. C377-C392
Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K. Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension. Cadiovasc Res. 2018. published online
YAMASHITA TETSUO, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, HIRANO Katsuya. Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Scientific Reports. 2018. 8. 1. 2427
A therapeutic agent and a preventive agent for pulmonary hypertension comprising thrombin receptor antagonist as an active ingredient
Nucleic acid and amino acid sequences of the degradation-resistant novel isoform of p27Kip1, and expression plasmid and cells expressing the protein
Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Humana Press, New York, 2013 ISBN:978-1-62703-085-4
The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
Springer, Tokyo, Japan 2017
Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity.
(11th International Symposium on Resistant Artery 2014)
Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption
(11th International Symposium on Resistant Artery 2014)