Research keywords (5)：
KEAP1-NRF2 regulatory system
, GATA 因子
, Erythropoietin
, Biobank
, Genome omics analysis
Research theme for competitive and other funds (95)：
2021 - 2026 Regulation of signal transduction via crosstalk between supersulfide and selenium
2019 - 2024 Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and Therapy
2019 - 2020 生体の酸化ストレス応答の分子メカニズム解明とその疾病予防・治療への応用
2018 - 2020 Elucidation of cytoprotective mechanisms by structural analysis of stress sensor Keap1
2015 - 2019 Promotion of oxygen biology on the basis of international networks
2015 - 2019 Mechanisms of leukemogenesis by the leukemia-driving enhancer
2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
2014 - 2019 Systemic mechanisms of response to hypoxic stresses
2015 - 2018 Mecahistic analysis of a protective response of skin tissue to UV genotoxicity
2015 - 2017 The role of Nrf2 in development and carcinogenesis of NASH using gene rescue mice
2014 - 2017 Elucidation of the mechanism of epithelial stem cell niche and its reproduction
2014 - 2017 The role of Nrf2 in oxidative stress-mediated insulin resistance
2014 - 2017 Search for novel physiological function of transcriptional factor Nrf2
2014 - 2017 The regulatory role of Nrf2 in pathogenesis and carcinogenesis of NASH using gene rescued mice
2014 - 2016 The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model mice
2014 - 2016 Identification of leukemia-initiating cells in an inv(3)(q21q26) mouse model
2012 - 2015 Roles of stress-responsive transcription factors in health and disease
2010 - 2015 Crosstalk between chromosome modification and transcription factors in the differentiation of hematopoietic cells
2012 - 2014 Analysis of leukemogenesis caused by disruption of gene regulatory mechanisms mediated by multiple transactivation domains
2011 - 2011 Mechanism of Nrf2-mediated self-renewal of hematopoietic stem cells
2010 - 2011 The role of Keap1-Nrf2 system in oxidative stress response of pancreatic β-cells
2010 - 2011 The functional analysis of a transcriptional factor GATA3 in an inner ear development.
2009 - 2011 Novel prevention of development of life style-related liver diseases and liver carcinogenesis through an activation of transcription factor induced by functional foods
2007 - 2011 Molecular Mechanisms of Adaptive Responses to Food and Oxygen
2010 - 2010 転写因子Nrf1の神経細胞恒常性維持機構の解明
2007 - 2009 From the ER to the plasma membrane : Vesicular transport of membrane skeleton units and the diseases
2005 - 2009 Roles of transcription factors for carcinogenesis and carcinogenesisdefense
2004 - 2009 Genetic and Epigenetic Dysregulation in Cancer
2006 - 2007 転写因子の発現量依存的な細胞運命決定機構の解明
2005 - 2007 動脈硬化の進行防止における転写因子Nrf2の役割
2005 - 2006 Study for the molecular mechanism of oxidative stress responsive transcription
2004 - 2006 Molecular pathology for down-regulation of erythroid-specific genes in prion diseases
2004 - 2005 Gene manipulation of hypoxia inducible gene regulation
2003 - 2004 Molecular mechanisms for hemato-vascular formation
2003 - 2004 Transcription factor regulation of malignant cell transformation and its repression
2002 - 2004 Analysis of lymph node metastasis of oral cancer by using peroxiredoxin I knockout mouse
2002 - 2004 Sensitive detection of air-born mutagens and their evaluation using gene knockout mice
2000 - 2004 転座関連遺伝子及び転写因子による細胞分化とがん化の分子機構
2002 - 2003 分化方向性の制御から挑む再生医工学
2002 - 2003 Molecular mechanisms for the assembly of the red cell membrane skeleton during erythroid cell development
2002 - 2003 赤芽球の増殖・分化・アポトーシスの制御におけるGATA因子の役割の解明
2001 - 2003 Gene Modification of Oxygen Responsiveness by Erythropoietin Gene
2001 - 2003 Construction of a repertoire of genetically altered mice for evaluating the toxicity of chemicals
2002 - 2002 転写制御複合体形成のダイナミクスとその生物機能の解明
2001 - 2002 Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice
2001 - 2002 Functional Contribution of Small Maf Proteins in Hematopoietic Cells
2001 - 2002 Functional analysis of BTEB and BTEB2 transcription factors by gene-targeting technology
2000 - 2001 APPLICATION OF GENE MANIPULATION TECHNOLOGY TO GENERATION OF MODEL ANIMALS FOR ENVIRONMENTAL ASSESSMENT
2000 - 2001 Development of monitoring system of toxic chemicals base on the Nrf2-dependent detoxification pathway
2000 - 2001 Molecular mechanism for the assembly of red cell membrane skeletons based on pathobiology of congenital hemolytic anemia in cattle
2000 - 2001 Analysis of biological function of regulatory network composed of bZip transcription factors
1999 - 2001 Study on a new defence system against oxidative stress
1998 - 2001 転写調節による造血分化制御
1997 - 2001 Transcriptional mechanisms controlling organized function in vertebrate
1999 - 2000 Nrf2による新しい酸化ストレス応答機構の解析
1999 - 2000 Function of bridging molecules in enhancer-promoter communication during erythropoieis
1999 - 2000 Analysis of GATA transcription factors functions on development and differentiation of hematopoietic cells.
1997 - 2000 Target genes and biological role of transcription factors in animal
1999 - 1999 血液細胞の分化と機能発現の制御機構の解明
1998 - 1999 Gene manipulation of heme synthetic pathway enzymes
1998 - 1999 Applications of Tissue-specific Transcription Factor in Animal Gene Therapy
1997 - 1999 Regulation and Function of Erythroid Transcription Factors.
1997 - 1998 小Maf群転写因子を用いた形質転換細胞の分化誘導
1997 - 1998 エリスロポエチン遺伝子の発現調節機構の解析
1997 - 1998 Development of New Therapeutic Strategy for Autoimmune Diseases through Gene Introduction of Oncogene c-maf.
1997 - 1998 Regulation of Disease Susceptibility through Gene Introduction of Transcriptiom Factors.
1997 - 1998 GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATION
1994 - 1998 Purification and ampliefication of hematopoietic stem cells
1996 - 1997 Transcription factors regulating the erytnroid and megakaryocytic cell differentiation.
1995 - 1997 Molecular Mechanism of Erythroid Differentiation
1996 - 1996 高等動物細胞の遺伝子発現における転写因子の相互作用と生物作用の分子機構
1996 - 1996 生殖細胞と支持細胞の機能的連関とGATA転写因子群
1996 - 1996 細胞の機能分化に関わる遺伝子制御ネットワーク-転写因子間相互作用-
1995 - 1996 Possible involvement of vascular cells-related transcription factors in human inflammatory diseases and cancer tissue.
1987 - 1988 Coupled Expression of The Genes Encoding The Constituents of The Glycine Cleavage System in Chicken
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Papers (1,200)：
Hiroshi Tawarayama, Keiko Uchida, Hirokazu Hasegawa, Masaaki Yoshida, Maki Inoue-Yanagimachi, Wataru Sato, Noriko Himori, Masayuki Yamamoto, Toru Nakazawa. Estrogen, via ESR2 receptor, prevents oxidative stress-induced Müller cell death and stimulates FGF2 production independently of NRF2, attenuating retinal degeneration. Experimental eye research. 2024. 248. 110103-110103
Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, et al. Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population. Rheumatology (Oxford, England). 2024
Akira Uruno, Shiori Kadoguchi-Igarashi, Ritsumi Saito, Shohei Koiso, Daisuke Saigusa, Ching-Tung Chu, Takafumi Suzuki, Takashi Saito, Takaomi C Saido, Antonio Cuadrado, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice. Journal of biochemistry. 2024
Nobuo Fuse, Masae Kimura, Ai Shimizu, Seizo Koshiba, Teruhiko Hamanaka, Makoto Nakamura, Nobuo Ishida, Hiroshi Sakai, Yoko Ikeda, Kazuhiko Mori, et al. Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals. Japanese journal of ophthalmology. 2024
Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, et al. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA journal. 2024. 7. 3. 353-363
伊藤ゆり, 井澤武史, 濱田菜々子, 田中美有, 田口恵子, 田口恵子, 山本雅之, 桑村充. Study on the activation of Nrf2 system in thioacetamide-induced GSTp-positive hepatocyte foci. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
内田新菜, 中井琢, 福内友子, 山岡法子, 小柴生造, 山本雅之, 鈴木教郎, 三枝大輔, 三枝大輔. Metabolic profiling of plasma and urine for the daprodustat treatment mice by GC-MS/MS. 日本薬学会年会要旨集(Web). 2024. 144th
芦野隆, 赤池哉太, 千葉莉沙子, 山本雅之, 沼澤聡. Role of Nrf2 antioxidative system on 5-fluorouracil-induced myelosuppression. 日本薬学会年会要旨集(Web). 2023. 143rd
2022/11 - Clarivate Analytics Highly Cited Researcher for 2022
2022/06 - University of Eastern Finland Honorary Doctorate
2021/11 - Clarivate Analytics Highly Cited Researcher for 2021
2021/08 - ISS Research Conference ISS Research Award for Dr Masayuki Yamamoto and MHU-3 Mission Team “Compelling Results in Biology and Medicine for their work on Nrf2 and the ToMMo project“
2021/03 - Society for Free Radical Research Lester Packer Award
2021/01 - 河北文化事業団 河北文化賞「生体の酸化ストレス応答機構の解明」
2020/11 - Clarivate Analytics Highly Cited Researcher for 2020
2020/06 - Federation of Asia and Oceania Biochemists and Molecular Biologists (FAOBMB) FAOBMB Research Excellence Award
2019/11 - Clarivate Analytics Highly Cited Researcher for 2019
2018/11 - Clarivate Analytics Highly Cited Researcher for 2018
