Rchr
J-GLOBAL ID：200901033308032209
Update date: Feb. 01, 2024
Sakurai Hiroshi
サクライ ヒロシ | Sakurai Hiroshi
Affiliation and department：
Research field (1)：
Molecular biology
Research keywords (5)：
signal transduction
, protein phosphatase
, protein kinase
, heat shock response
, stress
Research theme for competitive and other funds (24)：
- 2022 - 2026 運動と非アルコール性脂肪肝炎の改善をつなぐ制御分子機構の解明
- 2020 - 2023 Regulation of signal transduction and cell growth by protein phosphatase 2A
- 2019 - 2022 Elucidation of the mechanism of depression development focusing on protein misfolding.
- 2016 - 2019 熱ショック転写因子によるシャペロン非依存的恒常性維持機構の解明
- 2009 - 2012 熱ショック転写因子による遺伝子特異的な転写制御機構
- 2007 - 2009 熱ショック転写因子による多様な塩基配列の認識と生物間での普遍
- 2004 - 2007 ストレス応答における熱ショック転写因子のリン酸化制御
- 2001 - 2004 熱ショック転写因子と転写開始複合体の相互作用
- 2002 - 2004 Relation between the structure and function of proteins studied by the changes of tyrosine and tryptophan residues.
- 1998 - 2001 Relationship of function and higher order structure of abnormal hemoglobin.
- 2000 - 2000 転写開始複合体を形成するタンパク質間の遺伝子特異的な相互作用
- 2000 - 2000 転写開始から伸長反応への移行における転写因子の作用機構
- 1999 - 1999 転写調節因子およびプロモーター構造に特異的な転写開始機構
- 1999 - 1999 ヘモグロビンにおけるヘム鉄の蛋白質による機能制御
- 1999 - studies on mechanisms of stress response
- 1998 - 1998 転写調節における基本転写因子とプロモーターの特異的相互作用
- 1997 - 1998 基本転写因子のプロモーター構造特異的な作用機構
- 1996 - 1996 酵母転写因子GAL11と基本因子TFIIEの相互作用
- 1995 - 1995 酵母GAL80遺伝子の転写開始点結合タンパク質の機能解析
- 1994 - 1995 Structure and Function of Regulatory Circuit of Galactose-inducible Genes in Yeast
- 1994 - 1994 酵母GAL80遺伝子の転写開始点に依存した転写制御機構
- 1994 - 1994 酵母転写因子GAL11と相互作用する基本因子の研究
- 1994 - 1994 酵母のガラクトース応答機構
- Transcriptional regulation by yeast transcription factor GAL11
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Papers (65)：
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Hiroto Takeuchi, Mayuko Koga, Kuriko Doi, Hiroshi Sakurai. PP2A and its adapter protein IER5 induce the DNA-binding ability and target gene expression of E2F1 via dephosphorylation at serine 375. Biochimica et biophysica acta. Gene regulatory mechanisms. 2023. 1866. 3. 194960-194960
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Kuriko Doi, Hiroto Takeuchi, Hiroshi Sakurai. PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes. The FEBS journal. 2022
-
Takumi Ueda, Yuri Kohama, Hiroshi Sakurai. IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A. CELLULAR SIGNALLING. 2019. 55. 81-89
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Kohama Y, Saito M, Yada M, Sakurai H. Regulation of the stability and activity of CDC25A and CDC25B by protein phosphatase PP2A and 14-3-3 binding. Cellular signalling. 2018. 54. 10-16
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Nagashimada M, Ueda T, Ishita Y, Sakurai H. TAF7 is a heat-inducible unstable protein and is required for sustained expression of heat shock protein genes. The FEBS journal. 2018. 285. 17. 3215-3224
ｍore...
MISC (8)：
Education (5)：
- 1987 - 1990 Tokyo Metropolitan University Graduate School of Science
- - 1990 Tokyo Metropolitan University Graduate School, Division of Natural Science
- 1985 - 1987 Tokyo Metropolitan University Graduate School of Science
- 1981 - 1985 Tokyo Metropolitan University Faculty of Science Department of Biology
- - 1985 Tokyo Metropolitan University Faculty of Science
Professional career (1)：
Work history (7)：
Association Membership(s) (2)：
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