Yoshida Minoru

ヨシダミノル | Yoshida Minoru

Affiliation and department：
Job title： Executive Director
Other affiliations (1)：

The University of Tokyo

Homepage URL (1)： http://www.riken.jp/SPD/CG/index.html

Research field (2)： Applied molecular and cellular biology , Applied biochemistry

Research keywords (5)： Applied Microbiology , 化学遺伝子 , 化学生物学 , Chemical Genetics , Chemical Biology

Research theme for competitive and other funds (64)：

2023 - 2028 Chemical genetic approach to mode of action and biological validation of compounds from latent chemical space
2023 - 2028 天然物が織り成す化合物潜在空間が拓く生物活性分子デザイン
2022 - 2024 Utilization of an energy metabolic control compound to treat mitochondrial diseases
2021 - 2024 ミトコンドリア病治療法確立を目指したエネルギー代謝の化学的制御研究
2021 - 2023 Studies on functional and chemical diversity of siderophores produced by filamentous fungi

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Papers (452)：

Yusuke Toda, Hiroaki Fujita, Koshiki Mino, Takuto Koyama, Seiji Matsuoka, Toshie Kaizuka, Mari Agawa, Shigeyuki Matsumoto, Akiko Idei, Momoko Nishikori, et al. Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function. Cell Death & Disease. 2024. 15. 11
Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Seiji Matsuoka, Yuki Maemoto, Noriaki Hashimoto, et al. Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorganic & medicinal chemistry letters. 2024. 110. 129856-129856
Shin Ohsawa, Michaela Schwaiger, Vytautas Iesmantavicius, Rio Hashimoto, Hiromitsu Moriyama, Hiroaki Matoba, Go Hirai, Mikiko Sodeoka, Atsushi Hashimoto, Akihisa Matsuyama, et al. Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast. The EMBO Journal. 2024. 43. 20. 4604-4624
Hironori Saito, Yuma Handa, Mingming Chen, Tilman Schneider-Poetsch, Yuichi Shichino, Mari Takahashi, Daniel Romo, Minoru Yoshida, Alois Fürstner, Takuhiro Ito, et al. DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs. Nature Communications. 2024. 15. 1
Hiroaki Matoba, Kouhei Oba, Huanlin Li, Yuta Mizuno, Qianqian Wang, Makoto Yoritate, Mariko Aso, Mikiko Sodeoka, Minoru Yoshida, Yoko Yashiroda, et al. Structure-activity relationship study of nitrogen signaling factors. Bioorganic & Medicinal Chemistry Letters. 2024. 109. 129857-129857

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MISC (211)：

Ken Matsumoto, Minoru Yoshida. Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes-of-Action of Bioactive Compounds. ChemBioChem. 2022. 23. 7
岩崎信太郎, 岩崎信太郎, 吉田稔, 吉田稔, 吉田稔. Splicing modulation-mediated translational control. 生化学. 2022. 94. 6
天野日菜子, 平中誠弥, 式田亮史, 中田明子, 新真由美, 工藤紀雄, 伊藤孝, 伊藤昭博, 吉田稔, 布村一人, et al. Discovery of pyrilamine derivatives as isozyme-selective histone deacetylase 6 inhibitors. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)
Tilman Schneider-Poetsch, Jagat Krishna Chhipi-Shrestha, Minoru Yoshida. Splicing modulators: on the way from nature to clinic. The Journal of Antibiotics. 2021
小林大貴, 吉田稔. 機能低下したミトコンドリアを活性化させる化合物の発見. 実験医学. 2021. 39. 6. 954-957

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Patents (25)：

植物の耐塩性向上剤
癌の予防剤および/または治療剤
植物の耐塩性向上剤
ヒストンメチル化酵素活性の測定方法
ヘテロプラスミー細胞をホモプラスミー化する方法

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Books (30)：

ケミカルバイオロジー化合物集 -研究展開のヒント-
オーム社 2018 ISBN:9784274507090
Advances in Industrial Applications of Yeasts, Koji-molds, and Lactic Acid Bacteria
2018
Bioprobes: Biochemical Tools for Investigating Cell Function
Springer 2017
エピジェネティクス実験スタンダード (実験医学別冊)
2017
生物活性分子のケミカルバイオロジー標的同定と作用機構
化学同人 2015

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Lectures and oral presentations (1,066)：

微生物ケミカルゲノミクスを基盤とした化合物の作用機序研究
(日本農芸化学会中部支部第199回例会 2024)
抗生物質の作用機作研究が拓く真核細胞の化学遺伝学
(別府輝彦先生追悼シンポジウム 2024)
Chemical genomics reveals a novel link between eIF5A hypusination and mitochondrial integrity
(International Conference on the Biological Roles of Polyamines 2024)
Human eIF5A2 regulated by polyamines at translational level participates in mRNA decoding distinct from eIF5A1.
(International Conference on the Biological Roles of Polyamines 2024)
Regulation of the TEAD transcriptional factor by lysine long-chain fatty acylation
(FASEB Science Research Conferences, Biology of Acetylation in Health and Disease 2024)

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Professional career (1)：

Ph. D.

Work history (10)：

2023/04 - 現在 RIKEN Executive Director
2023/04 - 現在 Distinguished Professor of The University of TOKYO
2013/04 - 現在 RIKEN Center for Sustainable Resource Science Chemical Genomics Research Group Group Director
2022/04 - 2023/03 RIKEN Research Strategy Advisor
2017/04 - 2023/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Professor

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Committee career (64)：

2023/07 - 現在一般財団法人バイオインダストリー協会理事
2021/05 - 現在日本がん分子標的治療学会理事長
2020/10 - 現在日本がん分子標的治療学会理事
2018/06 - 現在第一三共生命科学研究振興財団選考委員会委員
2018/04 - 現在独立行政法人日本学術振興会HOPEミーティング運営委員会委員

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Awards (13)：

2022/11 - Person who has made outstanding cultural contributions
2018/12 - Cabinet Secretariat, Office of Healthcare Policy The Japan Medical Research and Development Grand Prize, the Healthcare Policy Minister's Prize Basic studies on molecular target drug discovery based on epigenetic regulation
2018/04 - 公益財団法人長瀬科学技術振興財団長瀬研究振興賞新規抗真菌抗生物質 ASP2397 の作用機序に関する化学遺伝学的研究
2017/02 - Princess Takamatsu Cancer Research Fund Princess Takamatsu Cancer Research Fund Prizes Chemical biology on cancer therapy targeting regulatory molecules of epigenetics
2015/06 - The Japan Academy Japan Academy Prize Studies on Regulation of Eukaryotic Gene Expression using Bioactive Microbial Metabolites and their Application to Drug Discovery

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Association Membership(s) (6)：

日本癌学会 , 日本分子生物学会 , 日本生化学会 , 日本農芸化学会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER

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