Rchr
J-GLOBAL ID：200901033490787350   Update date: Nov. 02, 2024

Mashima Tetsuo

マシマ テツオ | Mashima Tetsuo
Affiliation and department：
Japanese Foundation for Cancer Research Cancer Chemotherapy Center, Molecular Biotherapy Research

About Japanese Foundation for Cancer Research Cancer Chemotherapy Center, Molecular Biotherapy Research


Job title： Researcher
Homepage URL  (1)： https://scholar.google.com/citations?user=Yq7ZvtsAAAAJ&hl=en
Research field  (1)： Molecular biology
Research keywords  (19)： Drug-tolerant persister ,  drug resistance ,  cellular plasticity ,  cancer stemness ,  ALDH1A3 ,  Aldehyde dehydrogenase ,  Tankyrase ,  Wnt pathway ,  gastric cancer, colorectal cancer ,  patient-derived cells ,  Transcriptome analysis ,  molecular biomarker ,  molecular target screening ,  transrational research ,  VEGF receptor inhibitor ,  apoptosis ,  metabolic enzyme ,  prostate cancer ,  IL4I1/L-aimino acid oxidase
Research theme for competitive and other funds  (27)：
  • 2022 - 2028 先端モデル動物支援プラットフォーム
  • 2023 - 2025 Development of novel reprogramming therapy with tankyrase inhibitors by dual targeting of cancer microenvironment and stemness
  • 2021 - 2024 大腸癌治療薬の基礎解析データからの血中循環バイオマーカー同定と生物学的意義の解析
  • 2021 - 2024 胃がんの初期薬剤抵抗性を司るがん細胞の可塑性および安定維持機構の解明
  • 2022 - 分子プロファイリング支援活動・トランスクリプトーム解析
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Papers (73)：
  • Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Shingo Dan, Hiroyuki Seimiya, Kensei Yamaguchi. Exploratory Study Identifies Matrix Metalloproteinase;as Potential Biomarkers of Regorafenib;Efficacy in;Metastatic Colorectal Cancer. Cancers. 2024. 16. 16. 2855
  • Ryo Yanagiya, Yuji Miyatake, Natsumi Watanabe, Takanobu Shimizu, Akane Kanamori, Masaya Ueno, Sachiko Okabe, Joaquim Carreras, Shunya Nakayama, Ami Hasegawa, et al. Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia. Leukemia. 2024. 38. 8. 1731-1741
  • Ayane Nakamura, Tetsuo Mashima (corresponding author), Jin Lee, Saori Inaba, Naomi Kawata, Shun Morino, Koshi Kumagai, Kensei Yamaguchi, Hiroyuki Seimiya (corresponding). Intratumor transforming growth factor-β signaling with extracellular matrix-related gene regulation marks chemotherapy-resistant gastric cancer. Biochemical and biophysical research communications. 2024. 721. 150108-150108
  • Jin Lee, Tetsuo Mashima (corresponding author), Naomi Kawata, Noriko Yamamoto, Shun Morino, Saori Inaba, Ayane Nakamura, Koshi Kumagai, Takeru Wakatsuki, Kengo Takeuchi, et al. Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer. Cancer research communications. 2024
  • Shiho Hirose, Tetsuo Mashima, Xunmei Yuan, Makiko Yamashita, Shigehisa Kitano, Shinichi Torii, Toshiro Migita, Hiroyuki Seimiya. Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma. Cancer Science. 2024
ｍore...
MISC (41)：
  • 旦慎吾, 馬島哲夫. 細胞パネルおよびトランスクリプトーム解析による化合物プロファイリングと分子機序推定. 生体の科学. 2024. 75. 5. 464
  • 馬島哲夫, 清宮啓之. Cancer stemness of drug-tolerant gastric cancer cells and their cell survival pathways. 実験医学. 2021. 39. 12
  • 室井誠, 馬島哲夫, 牛嶋大, 松浦正明. オミックス解析:表現型・薬物活性とリンクする分子経路の探索. マウス・ラットモデル作製・解析プロフェッショナル(羊土社). 2021
  • 馬島 哲夫, 清宮 啓之. 【治療標的としてのがん幹細胞】がん幹細胞維持機構 総論 がん幹細胞と薬剤耐性. 医学のあゆみ. 2020. 273. 5. 356-361
  • 馬島哲夫, 冨田章弘. プロテアソーム阻害薬. 進化するがん創薬〜がん科学と薬物療法の最前線(化学同人). 2019
ｍore...
Patents (5)：
Education (2)：
  • The University of Tokyo
  • Musashi high school
Professional career (1)：
  • Ph.D.
Work history (3)：
  • 2014 - 現在 Japanese Foundation for Cancer Research Cancer Chemotherapy Center Senior Staff Scientist
  • 2009 - Broad Institute Visiting scientist
  • The University of Tokyo PD
Committee career (5)：
  • 2012/01 - 現在 Japanese Cancer Association councilor
  • Pharmaceutical Society of Japan Editor, Biol. Pharm. Bull
  • JFCR-ISCC Symposium Committee Member
  • 日本癌分子標的治療学会 選挙管理委員
  • 日本癌分子標的治療学会 評議員
Awards (2)：
  • The Young Investigator Awards of the Japanese Association for Molecular Target Therapy of Cancer
  • The Young Investigator Awards of the Japanese Cancer Association
Association Membership(s) (4)：
日本薬学会 ,  日本分子標的治療学会 ,  日本分子生物学会 ,  日本癌学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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