Rchr
J-GLOBAL ID：200901033762535827
Update date: Jun. 03, 2024
OGRA Yasumitsu
オグラ ヤスミツ | OGRA Yasumitsu
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
Homepage URL (1)：
http://www.p.chiba-u.jp/lab/yobou/index.html
Research field (5)：
Pharmaceuticals - health and biochemistry
, Forensic medicine
, Analytical chemistry
, Environmental effects of chemicals
, Pharmaceuticals - analytical and physicochemistry
Research keywords (2)：
生体微量元素 biometals スペシエーション speciation 銅 copper セレン selenium ミネラル mineral 栄養補助食品 supplements ICP-MS ICP-MS キャピラリーHPLC capillary HPLC 質量分析 mass spectrometry
, biometals speciation copper selenium mineral supplements ICP-MS capillary HPLC mass spectrometry
Research theme for competitive and other funds (28)：
- 2022 - 2024 Exploration of metabolomics associated with disaster-related death: Analysis of metabolome with hypothermia
- 2021 - 2024 Toxicological significance of metal biogenic nanoparticles
- 2019 - 2024 Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System
- 2019 - 2024 Development of advanced speciation for the matabolism of biometals
- 2019 - 2022 Research on the development and application of metallomics methods in the field of environmental medicine
- 2018 - 2021 Molecular mechanisms underlying the formation of bioorganometallic bond for metal toxicology
- 2018 - 2020 Mechanism underlying the generation of reactive cyanogen species
- 2017 - 2020 Synthesis and biological evaluation of selenoneine, naturally occurring selenium containing compound
- 2016 - 2019 tissue distribution and toxic mechanism of indium nano particles
- 2016 - 2019 Speciation and toxicological study of antimony in the environmental water in eastern and mid-southern China
- 2015 - 2018 Elucidation of the metabolism and toxicity mechanism of arsenolipids by analytical chemistry techniques
- 2015 - 2017 Verification of the structure of selenophosphate
- 2014 - 2017 Metallome analysis with cellular differentiation
- 2012 - 2014 Development of novel on-site analysis of urinary selenometabolites
- 2011 - 2014 Organotin-induced GluR2 decrease and its in vivo neuronal effects
- 2011 - 2014 Elucidation of Selenium Metabolism in mammalian cells by speciation
- 2011 - 2014 Tissue indium distribution after intratracheal instillation
- 2011 - 2012 Chemical speciation of blood selenium in a population with high intake of mercury
- 2007 - 2009 Mechanisms underlying circulation of selenium in Biosphere
- 2004 - 2007 Metallomics of bio-trace elements : Copper, selenium and arsenic
- 2004 - 2006 生体微量元素のナノスペシエーションの開発とメタロミクスにおける応用
- 2002 - 2003 尿中の主セレン代謝産物セレノシュガーの生成機構と生物学的意義
- 2001 - 2002 重金属の細胞内移動に着目したメタロチオネインの核内移行の機構
- 2000 - 2001 Mechanisms Underlying the Metabolic Pathway of Selenium and the Interactions between Selenium and Other Elements
- 1998 - 1999 細胞内における銅および亜鉛の輸送機構の解明
- 1997 - 1999 Mechanism underlying the selective removal of copper accumulating in the liver of LEC rats and development of the therapy for Wilson disease
- 1996 - Biological and Toxicological Roles of Heavy Metals and Metalloids
- 1996 - 重金属および類金属の生物学的および毒性学的機能の解明
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Papers (204)：
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Yu-Ki Tanaka, Yasumitsu Ogra. Quantitative determination of the intracellular uptake of silica nanoparticles using asymmetric flow field flow fractionation coupled with ICP mass spectrometry and their cytotoxicity in HepG2 cells. Archives of toxicology. 2024. 98. 3. 769-777
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Yoshikazu Yamagishi, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra. Evaluation of organophosphorus pesticide tyrosine adducts for post-mortem change by human serum albumin with liquid chromatography quadrupole orbitrap mass spectrometry. Toxicological sciences : an official journal of the Society of Toxicology. 2024
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Yasunori Fukumoto, Rin Kyono, Yuka Shibukawa, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra. Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion. Journal of Biological Chemistry. 2024. 300. 2. 105599-105599
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Yoshikazu Yamagishi, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra. Identification of post-mortem product of zolpidem degradation by hemoglobin via the Fenton reaction. The Journal of Toxicological Sciences. 2024. 49. 6. 261-268
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Yoshinari Suzuki, Midori Kondo, Masae Harimoto, Yusuke Okamoto, Yu-ki Tanaka, Yasumitsu Ogra, Hiroshi Akiyama. Bayesian estimation to deconvolute single-particle ICP-MS data with a mixed Poisson distribution. Journal of Analytical Atomic Spectrometry. 2024. 39. 1. 190-203
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MISC (55)：
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山本勝也, 山本勝也, 石田慶士, 松丸大輔, 田中佑樹, 小椋康光, 中西剛. カドミウムの肝臓への蓄積および毒性発現に対するリポカリン分子C8γの機能解析. Fundamental Toxicological Sciences (Web). 2023. 10. Supplement
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高田翔平, 山岸由和, 永澤明佳, 永澤明佳, 小椋康光. 植物中新規テルル酸代謝物の同定及び毒性評価. Fundamental Toxicological Sciences (Web). 2023. 10. Supplement
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山岸由和, 高橋一聡, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光. セレン含有化合物の選択的検出法の開発. Fundamental Toxicological Sciences (Web). 2023. 10. Supplement
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田中 昭代, 松村 渚, 田中 佑樹, 小椋 康光, 古閑 一憲, 白谷 正治, 長野 嘉介. インジウム・スズ酸化物ナノ粒子の体内動態に及ぼすサイズ効果. 大気環境学会年会講演要旨集. 2022. 63回. 3D1030-3D1030
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松村 渚, 田中 佑樹, 小椋 康光, 古閑 一憲, 白谷 正治, 長野 嘉介, 田中 昭代. インジウム・スズ酸化物ナノ粒子の皮下投与による亜慢性影響. Biomedical Research on Trace Elements. 2022. 33. 1. 137-137
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Patents (10)：
Books (3)：
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衛生薬学(改訂第2版): 基礎・予防・臨床
南江堂 2018 ISBN:452440354X
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Metallomics : recent analytical techniques and applications
Springer 2017 ISBN:9784431564614
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衛生薬学: 基礎・予防・臨床
南江堂 2016 ISBN:4524403175
Lectures and oral presentations (1)：
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システイン合成酵素高発現タバコにおけるカドミウム耐性形質の付与
(日本薬学会年会要旨集 2001)
Works (1)：
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Speciation of Selenium in Biological and Food Samples
Education (2)：
- - 1996 Graduate School of Pharmaceutical Sciences, Chiba University
- - 1991 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
Professional career (1)：
- Ph. D.(Pharmaceutical Sciences) (Chiba University)
Work history (6)：
Awards (9)：
- 2023/07 - The Japanese Society of Toxicology JSOT Award
- 2016/09 - 日本薬学会環境・衛生部会 学術賞
- 2016/06 - 日本毒性学会 日化協LRI賞
- 2014/03 - 日本薬学会 学術振興賞
- 2013/06 - Royal Society of Chemistry Fellow
- 2007/07 - 日本微量元素学会 奨励賞
- 2002/09 - Best oral presentation prize / 2nd Franco-Spanish workshop on Bio-Inoiganic Anarytial Chemistry
- 2001/11 - メタロチオネイン奨励賞
- 2001 - Young Scientist Award for Metallothionein
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Association Membership(s) (12)：
日本質量分析学会
, JAPANESE ASSOCIATION OF FORENSIC TOXICOLOGY
, Japanese Society of Food Chemistry
, Royal Society of Chemistry
, THE JAPANESE SOCIETY OF TOXICOLOGY
, LECラット研究会
, 日本微量元素学会
, 日本癌学会
, 日本生化学会
, 日本薬学会
, 日仏薬学会
, Society of Toxicology
