Research theme for competitive and other funds (31)：
2022 - 2025 ホロトランスロコン複合体による効率的タンパク質分泌の構造基盤
2022 - 2025 Structure and function of glycolipid MPIase involved in biogenesis of membrane proteins
2021 - 2024 統合的構造解析法による繊毛中心対複合体の構造解明
2021 - 2024 タンパク質の膜透過システムの4次元ダイナミクスとアッセンブリ
2021 - 2024 メガダルトン生命機能深化ダイナミクス
2021 - 2024 Autonomous biological systems of megadalton complexity
2021 - 2023 タンパク質膜透過駆動モーター SecA ATPase の駆動力を測定する
2019 - 2021 Preparation of membrane protein-containing nanoparticles and precise observation of membrane protein dynamics
2018 - 2021 Elucidation of the process of membrane protein insrtion and folding.
2018 - 2021 Structural basis and mechanism of Sec holo translocon complex
2019 - 2020 「動的構造生命科学を拓く新発想測定技術」の成果取りまとめを目指した組織活動
2017 - 2019 Development of biomembrane nanodisc for detergent-free analysis of membrane proteins
2015 - 2019 Support activities aimed at international network formation in the research area of dynamic structural life sciences
2014 - 2019 New measurement techniques for visualizing live protein molecules at work
2014 - 2019 Dynamics of protein secretion
2016 - 2018 Dynamism of a proton-driven protein translocation motor.
2015 - 2018 Elucidation of the structural basis of transporter proteins involved in metal tolerance
2015 - 2017 Construction of a new reconstruction system and analysis of dynamic protein secretion machinery
2014 - 2017 Structural basis for membrane protein integration
2012 - 2017 Elucidation of the working principle of repetitive motors driving protein export
2014 - 2015 タンパク質分泌システムの精密探査を可能とする新しい再構成系の構築
2012 - 2014 Structural basis of membrane protein insertion
2012 - 2014 タンパク質膜透過・膜組込み時に形成するリボソームを含む過渡的複合体の解析
2010 - 2012 SecDF function and roles of the proton motive force in protein translocation
2010 - 2011 膜タンパク質の膜組み込みの構造生物学
2010 - 2011 Secトランスロコンを含む過渡的複合体の構造生物学
2009 - 2011 Structural and biochemical analysis of Sec translocon machinery
2009 - 2010 分子モーターSecA ATPaseによるタンパク質膜透過機構の構造機能相関
2007 - 2008 生体膜を介した物質輸送の構造生物学的研究
2007 - 2008 細胞膜に関連したエネルギー変換マシーナリーの構造・機能相関
Sec トランスロコン マシーナリーの解明
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Papers (56)：
Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S. Takahashi, Yoshiki Tanaka, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki. Structure and function of a YeeE-YeeD complex for sophisticated thiosulfate uptake. 2023
Hidetaka Kohga, Napathip Lertpreedakorn, Ryoji Miyazaki, Tomoya Tsukazaki. Critical residues of the antibiotic peptide LysMthat inhibits lipid II flipping. 2023
Ryoji Miyazaki, Mengting Ai, Natsuko Tanaka, Takehiro Suzuki, Naoshi Dhomae, Tomoya Tsukazaki, Yoshinori Akiyama, Hiroyuki Mori. Inner membrane YfgM-PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation. The Journal of biological chemistry. 2022. 298. 11. 102572-102572
Hiroshi Inaba, Yurina Sueki, Muneyoshi Ichikawa, Arif Md. Rashedul Kabir, Takashi Iwasaki, Hideki Shigematsu, Akira Kakugo, Kazuki Sada, Tomoya Tsukazaki, Kazunori Matsuura. Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside. Science Advances. 2022. 8. 36
Hidetaka Kohga, Takaharu Mori, Yoshiki Tanaka, Kunihito Yoshikaie, Katsuhide Taniguchi, Kei Fujimoto, Lisa Fritz, Tanja Schneider, Tomoya Tsukazaki. Crystal structure of the lipid flippase MurJ in a "squeezed" form distinct from its inward- and outward-facing forms. Structure (London, England : 1993). 2022
