Rchr

J-GLOBAL ID：200901034567758028 Update date: Sep. 19, 2024

Manabe Noboru

マナベノボル | Manabe Noboru

Affiliation and department：
Job title：理事

Research field (4)： Animal production science , Human pathology , Laboratory animal science , Veterinary medicine

Research keywords (32)：卵巣 , アポトーシス , 卵胞 , モノクロナール抗体 , 顆粒層細胞 , 細胞死受容体 , 哺乳類 , ブタ , アポトーシス阻害因子 , カスパーゼ , 卵胞閉鎖 , 発現制御 , 家畜 , 胎児奇形 , 卵母細胞 , プログラム細胞死 , オーファン受容体 , 外因性内分泌攪乱物質 , ブタ卵巣 , 食物連鎖 , 細胞死阻害因子 , 生殖毒性 , 生殖腺 , 生体核磁気共鳴装置 , 構造生物学 , 生殖生理学 , 環境汚染物質 , 遺伝毒性 , 環境ホルモン , 核磁気共鳴装置 , 生殖生物学 , Anatomy and Cell Biology

Research theme for competitive and other funds (39)：

1992 - 2018 哺乳類卵胞の選択的死滅制御機構とその人為支配による潜在的卵巣卵の利用
2014 - 2017 Evaluation method for quality the farm animal egg: Based on the molecular mechanism of follicle selection
2012 - 2014 Rescue of potential oocytes in livestock ovaries by artificial control of apoptosis inhibitor
2010 - 2013 Creation of judging method for livestock egg quality based on the molecular mechanism of follicular selection
2009 - 2011 Creation of rescue system for potential oocytes by apoptosis inhibitory factor gene transfer and xenotransplantation techniques

2006 - 2010 Remodeling on molecular mechanisms of pregnancy establishment and regulation

2006 - 2009 Development of estimation method for mammalian oocyte quality based on molecular mechanism of follicular selection

1982 - 2009 細胞外マトリックスの制御機構に関する研究

2006 - 2008 細胞死阻害因子の遺伝子導入による卵巣内潜在的卵母細胞を救命する異種移植法の開発

2004 - 2008 Development of fundamental basis for embryo-biotechnology in next generation by clarifying the regulatory mechanisms of cell differentiation and apoptosis of oocytes

2005 - 2007 Comparative studies on beta amyloid deposition and brain aging

2005 - 2007 Development of Cryopresservation technique for ovarian germline stem cells

2001 - 2005 哺乳類卵胞の選択的死滅制御機構とその人為支配による潜在的卵巣卵の利用

2002 - 2003 耐凍タンパク等の遺伝子導入による卵巣凍結保存法の創出

2002 - 2003 Real-time assessment technique for reproductive toxicity of environmental disruptors by nuclear magnetic resonance microscopy

2001 - 2003 内分泌攪乱物質による生殖毒性評価システムの構築:構造生物学・細胞生物学的リアルタイム評価法の確立

2002 - 2002 体細胞クローン動物の誕生によって変貌した研究フロンティアの推進

2000 - 2002 選択的卵胞閉鎖の分子制御機構の解明とその人為支配

2000 - 2002 Approach to the cure oriented therapy for chronic renal disease by the establishment of a disease model mouse strain which shows naturally occurring nephritic syndrome

1999 - 2002 Non-invasive assessment for teratogenic-toxicity of environmental disrupters by structural- and cel lurar-biological methods

2001 - 2001 家畜卵胞の選択的死滅を支配する新規な卵胞上皮細胞特異的アポトーシス受容体の同定

2000 - 2001 耐凍性タンパク質遺伝子等のexvivo導入による卵巣の凍結保存

1999 - 2001 Regulation mechanisms of germinal cell selection in mammals and its artificial control

1999 - 2000 卵胞の選択的死滅を決定する新規顆粒層細胞特異的アポトーシス受容体の探索とその制御

1998 - 2000 Evaluation of Indication for Liver Transplantation in Primary Liver Cancers : Focused on Analysis of Multicentric Liver Cancers and Relapse of Prediction.

1997 - 2000 A novel structural biological assessment for reproductive and genetic toxicity in farm animals using nuclear magnetic resonance technique

1998 - 1999 耐凍蛋白遺伝子のex vivo導入による生殖器官の凍結保存

1997 - 1999 Selective death of ovarian follicles : ldentification and regulation of novel apoptosis receptor in granulosa cells

1997 - 1998 卵胞顆粒層細胞にのみ特異的にアポトーシスを誘導する新規な細胞死受容体の探索

1996 - 1998 Regulatory mechanisms of granulosa cell apoptosis in porcine ovarian follicle atresia

1997 - 1997 生殖遺伝毒性の評価:環境汚染物質による生殖遺伝毒性の構造生物学的評価法の創出

1995 - 1997 Novel application of small domestic herbivora raised by discarded recycling resources

1995 - 1997 Study on maturation and replication mechanisms of Pestivirus and hepatitis C virus

1995 - 1996 Regulation mechanisms in granulosa cell apoptosis in follicular atresia

1994 - 1996 A novel assessment technique of reproductive and genetic toxicity in domestic animals using a nuclear magnetic resonance instrument

1993 - 1995 Artificial control of oocyte maturation by in vitro perfused organ culture of the ovaries of farm animals

1993 - 1994 Histochemical Microquantitation for Extracellular Matrix Proteins and mRNAs in Mammalian Histologic Sections

1992 - Molecular mechanism of apoptosis in granulosa cells of ovarian follicles.

1982 - Study on extracellular matrix metabolisms in the experimental model animals with fibrotic diseases.

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Papers (107)：

Kozue Uchio-Yamada, Keiko Yasuda, Kentaro Oh-hashi, Noboru Manabe. Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis. American Journal of Physiology-Renal Physiology. 2022
Kozue Uchio-Yamada, Keiko Yasuda, Yoko Monobe, Ken-ichi Akagi, Osamu Suzuki, Noboru Manabe. Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier. American Journal of Physiology-Renal Physiology. 2020. 318. 6. F1520-F1530
Kozue Uchio-Yamada, Yoko Monobe, Ken-ichi Akagi, Yoshie Yamamoto, Atsuo Ogura, Noboru Manabe. Tensin2-deficient mice on FVB/N background develop severe glomerular disease. JOURNAL OF VETERINARY MEDICAL SCIENCE. 2016. 78. 5. 811-818
Toshikiyo Takahashi, Kouya Sasaki, Tamas Somfai, Takashi Nagai, Noboru Manabe, Keisuke Edashige. N, N-Dimethylglycine decreases oxidative stress and improves in vitro development of bovine embryos. JOURNAL OF REPRODUCTION AND DEVELOPMENT. 2016. 62. 2. 209-212
Kohsyo Yamauchi, Noboru Manabe, Yoshiki Matsumoto, Shin-ichi Takenoyama, Koh-en Yamauchi. Increased collagen III in culled chicken meat after feeding dietary wood charcoal and vinegar contributes to palatability and tenderness. ANIMAL SCIENCE JOURNAL. 2014. 85. 4. 468-480

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MISC (199)：

N. Manabe, T. Sai, F. Matsuda, I. Onoyama, J-Y Li. Bcl-2 members Bid and Bax are involved in granulosa cell apoptosis in saws. REPRODUCTION IN DOMESTIC ANIMALS. 2012. 47. 498-498
松田二子, 眞鍋昇. 抗アポトーシス因子・cellular FLICE-inhibitory protein (cFLIP) による哺乳類の卵胞選抜制御機構. 比較内分泌学. 2012. 38. 144. 27-32
Fuko Matsuda, Naoko Inoue, Noboru Manabe, Satoshi Ohkura. Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells. JOURNAL OF REPRODUCTION AND DEVELOPMENT. 2012. 58. 1. 44-50
鈴木千恵, 山田学, 吉岡耕治, 野口倫子, 眞鍋昇. 豚の偽妊娠および妊娠黄体におけるtumor necrosis factor(TNF)-α関連因子の発現解析. The Journal of Reproduction and Development. 2010. 56. Suppl. j116-j116
Thanh Quang Dang-Nguyen, Nguyen Khac Tich, Bui Xuan Nguyen, Manabu Ozawa, Kazuhiro Kikuchi, Noboru Manabe, Jozsef Ratky, Yukio Kanai, Takashi Nagai. Introduction of various Vietnamese indigenous pig breeds and their conservation by using assisted reproductive techniques. Journal of Reproduction and Development. 2010. 56. 1. 31-35

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Patents (1)：

組織の冷却保存液

Books (81)：

Ovarian follicle selection. In: The Ovary, 2nd edition
Elsevier Science 2004
Ovarian follicle selection. In: The Ovary, 2nd edition
Elsevier Science 2004
Ovary. In: Biology of Reproduction 2nd edition
Asakura Pub. Co. 2003
Female reproductive organs. In: Veterinary Histology 3rd edition.
Gakusoshya Pub. Co. 2003
In vivo and real time estimation of energy metabolism by 31p-nuclear magnetic resonance. In: Animal Frontier Science
Hokuto Pub. Co. 2003

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Works (2)：

遺伝子操作による卵胞退行閉鎖の制御
2001 - 2007
Reguration of follicular atresia by gene manupilation
2001 - 2007

Education (4)：

- 1983 Kyoto University
- 1983 Kyoto University Graduate School, Division of Agriculture Department of Animal Sciences
- 1978 Kyoto University Faculty of Agriculture
- 1978 Kyoto University Faculty of Agriculture Department of Animal Sciences

Professional career (1)：

Doctor of Agriculture (Kyoto University)

Work history (1)：

2004 - 2015 The University of Tokyo

Committee career (9)：

1994 - 2006 関西畜産学会評議員
2006 - アジア獣医解剖学会理事・事務局長・機関誌編集委員長
2000 - 2004 日本農芸化学会代議員
2003 - アジア太洋州畜産学会編集委員
2003 - 欧州細胞病理学会評議員

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Awards (2)：

1998 - 日本畜産学会賞
1989 - 欧州細胞病理学会奨励賞

Association Membership(s) (11)：

アジア獣医解剖学会 , アジア太洋州畜産学会 , 日本獣医解剖学会 , 欧州細胞病理学会 , 関西畜産学会 , 日本農芸化学会 , 日本薬学会 , 日本繁殖生物学会 , 日本解剖学会 , 日本獣医学会 , 日本畜産学会

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