Rchr
J-GLOBAL ID:200901034589648153
Update date: Nov. 17, 2024
Inoue Tomio
イノウエ トミオ | Inoue Tomio
Affiliation and department:
Job title:
Professor
Other affiliations (1):
-
Showa University
Professor emeritus
Homepage URL (1):
http://www10.showa-u.ac.jp/~oralphys/
Research field (1):
Oral medicine
Research keywords (16):
Mastication
, Swallowing
, Suckling
, 2光子励起顕微鏡
, カルシウム
, Serotonin
, オプトジェネティクス
, Orexin
, イメージング
, Patch-clamp recording
, arterially perfused decerebrate preparation
, Brain slice preparation
, Sleep
, Brain stem
, 摂食行動
, Trigeminal Nervous System
Research theme for competitive and other funds (53):
- 2022 - 2025 The role of the serotonergic system in the development of feeding
- 2022 - 2025 遺伝子工学を用いた孤束核嚥下ニューロンの網羅的解析
- 2022 - 2025 漢方薬を活用した口腔乾燥改善薬開発 ~iPS細胞と臨床による検証~
- 2021 - 2024 Elucidation of mechanism of sleep bruxism in the interrelation between serotonin and GABA
- 2020 - 2024 リポジトリとiPS細胞バンクを基盤とした睡眠時ブラキシズム発症機序の解明
- 2021 - 2023 咀嚼と機能連関する唾液分泌の中枢神経メカニズムの解明
- 2019 - 2023 Phox2B陽性ニューロンを基にした咀嚼運動形成回路の解明
- 2019 - 2023 咀嚼機能の獲得における抑制性シナプス形成の役割の解明
- 2018 - 2022 Elucidation of sleep bruxism mechanism using chemogenetic analysis of neural circuit assembly
- 2018 - 2021 Elucidation of mechanism for mastication of orexin
- 2019 - 2021 大脳除去マウス動脈灌流標本の咀嚼・嚥下機能を指標にした食欲不振実験モデルの開発
- 2016 - 2020 Involvement of oral sensation and masticatory movement in inhibition of feeding by histamine
- 2016 - 2020 Research in the excitatory synaptic transmission during critical period of feeding
- 2017 - 2020 光操作技術を用いた咀嚼筋活動制御におけるセロトニン神経系の役割の解明
- 2015 - 2019 Experimental study on involvement of the central nervous system in inferior alveolar nerve damage-associated hyperalgesia of the mental region
- 2015 - 2019 Mechanism of bone destruction by transcription factor IRF8
- 2017 - 2019 咀嚼運動と自律神経系のクロストークの解明
- 2015 - 2018 Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy
- 2015 - 2017 The involvement of microglia and early molecular signaling in the jaw face of abnormal pain onset
- 2014 - 2017 Study on relation of projection from the prefrontal cortex to the trigeminal mesencephalic nucleus, to processing of orofacial sensations, jaw-movements, or responses to stressful stimuli
- 2015 - 2017 動脈灌流標本を用いた舌根沈下の中枢メカニズムの解明
- 2014 - 2017 新規動物実験モデルを用いた嚥下の中枢制御機構の解明
- 2013 - 2015 p38 phosphorylation and caspase1 in medullary microglia mediates ectopic orofacial inflammatory
- 2012 - 2014 The establishment of bruxism mouse model and the elucidation of pathogenic factors of bruxism
- 2012 - 2014 Investigation into the mechanism in the development of disorder of masticatory and swallowing centers using time and brain-specific conditional knockout mice
- 2011 - 2014 Dendritic signal processing in the trigeminal motoneurons
- 2009 - 2011 Integrated study on mechanism of development and disorder of masticatory and swallowing function and visualization of neural circuits
- 2008 - 2010 Analysis of neural mechanisms underlying coodination of jaw, tongue, lip and cheek movements
- 2000 - 2010 Relationship between respiration and oral fanction
- 1993 - 2010 Effects of serotonergic inputs on mastication
- 1993 - 2010 Neural network controlling mastication
- 2006 - 2007 Neuronal Mechanisms of Cerebral Cortex Controlling Trigeminal Mesencephalic Spindle Atfetents for Smooth Mastication
- 2005 - 2006 Postnatal development of the local neural circuit controlling jaw movement
- 2005 - 2006 Neuroscientific studies on brain mechanisms controlling ingestive behavior on the basis of cognitive and affective aspects of taste.
- 2002 - 2004 Neuroscientific studies on brain mechanisms of affective behavior, learning and memory of taste.
- 2002 - 2003 Defference in physiological and mophological properties between jaw-closing and opening motoneurons
- 2000 - 2001 The role of the nigrostriatal dopaminergic pathway in the sequential progress
- 1999 - 2001 The basic study for the maintenance of oral health in an aging society
- 1999 - 2000 Development of trigeminal motoneuron
- 1998 - 2000 The study for co-relationship between the oral functions and the bioactive materials in brain
- 1999 - 1999 三叉神経運動ニューロンの細胞体および樹状突起からのパッチクランプ同時記録
- 1997 - 1998 三叉神経運動ニューロンの培養系の確立と細胞内情報伝達物質の光学的測定による解析
- 1997 - 1998 Modulatory inputs to trigeminal motoneurons in rat slice preparation
- 1997 - 1998 Electrophysiological analysis of the lateral reticular formation controlling orofacial autonomic and motor functions
- 1995 - 1997 Neural control of hyperactivity and spasm in the masticatory muscles.
- 1995 - 1996 Modulatory inputs to trigeminal motoneurons in rat slice preparation
- 1995 - 1996 Electrophysiological analysis of the lateral reticular formation subserving autonomic and motor oral functions
- 1993 - 1994 Neural network in the brainstem subserving reflex salivation
- 1993 - 1994 Analysis of neural network responsible for matication in slice preparation
- 1993 - 1994 Physiological Analysis of Oral Functions under Stress Conditions
- 1989 - 1989 三叉神経運動核周辺網様体への感覚入力と大脳皮質性入力
- 1987 - 1988 A role of muscle spindle afferents in the control of masticatory jaw movements.
- Membrane properties of trigeminal motoneurons
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Papers (120):
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Masanori Dantsuji, Ayako Mochizuki, Kiyomi Nakayama, Mitsuko Kanamaru, Masahiko Izumizaki, Kenji F Tanaka, Tomio Inoue, Shiro Nakamura. Optogenetic activation of serotonergic neurons changes masticatory movement in freely moving mice. Scientific reports. 2024. 14. 1. 27703-27703
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Minako Ikeda, Ayako Mochizuki, Takafumi Kato, Shiro Nakamura, Kiyomi Nakayama, Masanori Dantsuji, Kazuyoshi Baba, Tomio Inoue. Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice. Neuroscience Research. 2024. in press
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Masatoshi Takakura, Ayano Mizutani, Mizuki Kudo, Airi Ishikawa, Takuya Okamoto, Tong Xuan Fu, Shin-ichiro Kurimoto, Yuka Koike, Kenji Mishima, Junichi Tanaka, et al. Goji Berry Juice Prevents Tumor Necrosis Factor Alpha-Induced Xerostomia in Human Salivary Gland Cells. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 138-144
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Yoshifumi Abe, Sho Yagishita, Hiromi Sano, Yuki Sugiura, Masanori Dantsuji, Toru Suzuki, Ayako Mochizuki, Daisuke Yoshimaru, Junichi Hata, Mami Matsumoto, et al. Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia. Cell Reports Medicine. 2023. 4. 10. 101208-101208
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Shiori Koyama, Kiyomi Nakayama, Ayako Mochizuki, Masanori Dantsuji, Shiro Nakamura, Koutaro Maki, Tomio Inoue. Optical imaging of neurons related to fictive swallowing using GCaMP6f in an arterially perfused rat preparation. Journal of Oral Biosciences. 2023. 65. 1. 126-131
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MISC (132):
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澁川 義幸, 木村 麻記, 黄地 健仁, 一戸 達也, 中村 史朗, 井上 富雄. 三叉神経中脳路核ニューロンの歯根膜機械・固有感覚を担う分子基盤 : 機械感受性イオンチャネル-感覚調節機能連関解析-2021年度 東京歯科大学口腔科学研究センターワークショップ ; 共同研究プロジェクト 研究成果報告 ; 分子レベルによる口腔疾患の病因解明と新たな診断・治療法の開発. 歯科学報 = The journal of the Tokyo Dental College Society. 2022. 122. 3. 268-271
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権 洗眞, 黄地 健仁, 木村 麻記, 中村 史朗, 井上 富雄, 澁川 義幸, 一戸 達也. 歯根膜固有感覚を支配する三叉神経中脳路核ニューロンの機械感受性の検討(Mechanosensitivity of mesencephalic trigeminal nucleus neurons). Journal of Oral Biosciences Supplement. 2022. 2022. 183-183
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田上 聖章, 黄地 健仁, 木村 麻記, 倉島 竜哉, 石井 武展, 中村 史朗, 井上 富雄, 澁川 義幸, 西井 康. 三叉神経中脳路核の末梢ニューロンマーカー・イオンチャネル発現(Peripheral neuronal markers and ion channel expression in cells of trigeminal mesencephalic nucleus). Journal of Oral Biosciences Supplement. 2022. 2022. 187-187
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壇辻 昌典, 中村 史朗, 中山 希世美, 望月 文子, 井上 富雄. ブレインサイエンスが拓く、咬合咀嚼の生理学 顎運動制御におけるセロトニン神経系の役割(The role of serotonergic system in jaw movement control). Journal of Oral Biosciences Supplement. 2022. 2022. 69-69
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中村 史朗, 野口 毅, 梶原 里紗, 中山 希世美, 望月 文子, 壇辻 昌典, 井上 富雄. 生後発達期における閉口筋・開口筋運動ニューロンの興奮性および抑制性シナプス入力(Motoneuron-specific maturation of excitatory and inhibitory inputs to jaw-closing and jaw-opening motoneurons during postnatal period). Journal of Oral Biosciences Supplement. 2022. 2022. 318-318
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Books (41):
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咀嚼の本3 嚙むことの大切さを再認識しよう
一般財団法人 口腔保健協会 2022 ISBN:9784896053883
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Research and evaluation strategies for stomatognathic function - 2017 -
Japanese Society of Stomatognathic Function 2022 ISBN:9784990335250
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有床義歯補綴学(山下秀一郎、大川周治、佐々木啓一、武部純、馬場一美、水口俊介編)
永末書店 2021 ISBN:9784816013836
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基礎歯科生理学 第7版(岩田幸一、井上富雄、舩橋 誠、加藤隆史編)
医歯薬出版 2020 ISBN:9784263458464
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ザ・ペリオドントロジー 第3版(沼部幸博、梅田誠、齋藤淳、山本松男編)
永末書店 2019
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Lectures and oral presentations (11):
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転写調節因子Phox2bを発現するニューロンは咀嚼様顎運動の誘発と咀嚼に伴う唾液分泌に関わる可能性がある
(第65回歯科基礎医学会学術大会 2023)
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転写調節因子Phox2bを発現するニューロンの咀嚼様顎運動リズム形成と唾液分泌制御に対する役割
(第64回歯科基礎医学会学術大会(歯科イノベーションロードマップシンポジウム 『健康長寿社会を目指す口腔機能低下の予防と回復法の確立』) 2022)
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加齢に伴う口腔機能低下と大脳皮質機能
(日本老年歯科医学会第32回学術大会(シンポジウム 1; 口腔機能の生理的老化と病的老化) 2021)
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Properties of Phox2b-expressing premotor neurons targeting jaw-muscle motoneurons
(The 9th Federation of the Asian and Oceanian Physiological Societies Congress (Symposium 11; Advances in the mastication and swallowing physiology to prepare for an aging society) 2019)
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閉口筋運動ニューロンにおけるグルタミン酸性シナプス応答のセロトニンによる増強
(第60回歯科基礎医学会学術大会(メインシンポジウム2; 食に関わる運動・感覚の生理学) 2018)
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Works (1):
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Functon and disorder of the Brain
2002 -
Education (2):
- 1982 - 1987 Osaka University
- 1976 - 1982 Osaka University School of Dentistry School of Dentistry
Professional career (1):
Work history (8):
- 2024/09 - 現在 Kyoto Koka Women's College Department of Dental Hygiene Professor
- 2024/04 - 現在 Kyoto Koka Women's College Department of Dental Hygiene Professor
- 2023/04 - 現在 Showa University Professor emeritus
- 2023/04 - 2024/03 Kyoto Koka Women's College Department of Contemporary Life Design Professor
- 2000/04 - 2023/03 Showa University School of Dentistry Professor
- 1993/01 - 2000/03 Osaka University School of Dentistry associate professor
- 1986/04 - 1992/12 Osaka University School of Dentistry assistant professor
- 1990/04 - 1992/08 UCLA Department of Dentistry / Physiological Science Postdoc researcher
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Committee career (5):
- 2021/01 - 現在 Japanese Society for Mastication Science and Health Promotion Director
- 2005/04 - 現在 日本生理学会 評議員
- 2021/07 - 2023/06 日本歯科医学会 常任理事
- 2020/06 - 2022/09 Japanese Association for Oral Biology President
- 2010/04 - 2012/03 日本顎口腔機能学会 会長
Awards (3):
- 2024/02 - Japanese Association for Dental Science Japanese Association for Dental Science President's Award
- 2012/05 - 昭和大学 上條奨学賞 基礎歯科医学教育の充実への貢献
- 1999/12 - 第2回大阪大学歯学部弓倉学術奨励賞
Association Membership(s) (10):
JAPANESE SOCIETY FOR MASTICATION SCIENCE AND HEALTH PROMOTION
, THE JAPANESE SOCIETY FOR TEMPOROMANDIBULAR JOINT
, JAPANESE SOCIETY OF ORAL IMPLANTOLOGY
, 昭和学士会
, 日本歯科医学教育学会
, Society for Neuroscience
, 日本顎口腔機能学会
, 日本神経科学学会
, 日本生理学会
, 歯科基礎医学会
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