Rchr
J-GLOBAL ID：200901034667058619
Update date: Feb. 01, 2024
Higashiyama Kimio
ヒガシヤマ キミオ | Higashiyama Kimio
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://polaris.hoshi.ac.jp/kyoshitsu/gousei/gousei.html
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (2)：
医薬品化学
, Medicinal Chemistry
Research theme for competitive and other funds (5)：
- 2006 - 2008 Development research into obesity improvement medicine
- 1996 - 1997 Promoting activity of menthol derivatives containing sulfur atom on the percutaneous absorption of drugs
- 1994 - 1995 Development of novel percutaneous absorption promoters
- Asymmetric Synthesis of Aziridine Derivatives and Their Ring-Opening Reaction
- Stereoselective Reaction of Chiral Imines and 1,3-Oxazolidines with Organometallic Reagent
Papers (73)：
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Eizoh Gondoh, Yusuke Hamada, Tomohisa Mori, Yusuke Iwazawa, Asami Shinohara, Michiko Narita, Daisuke Sato, Hiroyuki Tezuka, Takayasu Yamauchi, Mayu Tsujimura, et al. Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine. British journal of cancer. 2022. 127. 8. 1565-1574
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Tomohisa Mori, Yoshinori Takemura, Takamichi Arima, Yoshiyuki Iwase, Michiko Narita, Kanako Miyano, Yusuke Hamada, Yukari Suda, Akinobu Matsuzawa, Kazuyuki Sugita, et al. Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine. Biochemical and Biophysical Research Communications. 2021. 534. 988-994
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Yuya Chikayuki, Takakane Miyashige, Shiori Yonekawa, Akiko Kirita, Natsuko Matsuo, Hiroyoshi Teramoto, Shigeru Sasaki, Kimio Higashiyama, Takayasu Yamauchi. Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N -Propargyl Enamines. Synthesis (Germany). 2020. 52. 7. 1113-1121
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Yuya Chikayuki, Yasuaki Kouno, Shiori Yonekawa, Haruka Ishikawa, Yoko Waki, Hiroyoshi Teramoto, Shigeru Sasaki, Kimio Higashiyama, Takayasu Yamauchi. Transition metal-free cyclization of N-boc-N-propargylenamines. Heterocycles. 2020. 100. 5. 719-746
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Shigeru Sasaki, Satono Watanabe, Kaori Shiino, Yuko Yanaka, Shiho Kaneko, Kana Miyamoto, Ayano Yasui, Hina Sakaino, Hiroyoshi Teramoto, Takayasu Yamauchi, et al. Substituent effects in regio- And stereoselective ring-opening reaction of aziridines with ET3N·3HF for β-fluoroamine synthesis. Heterocycles. 2018. 97. 2. 823-841
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MISC (59)：
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岩瀬 祥之, 森 友久, 中村 美聖, 肥田野 翔, 芝崎 真裕, 増川 太輝, 東山 公男, 五嶋 良郎, 鈴木 勉. 薬物依存の研究(第495報) DOPAのmethamphetamine誘発報酬効果形成における関与. 日本アルコール・薬物医学会雑誌. 2014. 49. 4. 228-228
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Takayasu Yamauchi, Sachi Hagiwara, Kimio Higashiyama. Concise Total Synthesis of (-)-Deoxocuscohygrine and (-)-Dihydrocuscohygrine (vol 73, pg 9784, 2008). JOURNAL OF ORGANIC CHEMISTRY. 2011. 76. 15. 6464-6464
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李 超傑, 呉 宝珠, 小幡 誉子, 藤川 未来人, 東山 公男, 永井 恒司, 高山 幸三. 人工ニューラルネットワークを組み込んだ多目的同時最適化法による 1-O-ethyl-3-butylcyclohexanol 添加ケトプロフェンゲル処方の最適化. 薬剤学 = Journal of Pharmaceutical Science and Technology, Japan. 2003. 63
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李 超傑, 小幡 誉子, 東山 公男, 永井 恒司, 高山 幸三. 1-O-Ethyl-3-butylcyclohexanolの経皮吸収促進効果と薬物物性との関係. 薬剤学. 2002. 62
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Jun-Ichi Sudo, Hiroaki Iwase, Kimio Higashiyama, Katsuhiko Kakuno, Fumiji Miyasaka, Takashi Meguro, Kozo Takayama. Elevation of plasma levels of L-dopa in transdermal administration of L-dopa-butylester in rats. Drug development and industrial pharmacy. 2002. 28. 1. 59-65
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Patents (6)：
Professional career (1)：
Association Membership(s) (1)：
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