Research field (2)：
Clinical pharmacy
, Cell biology
Research keywords (2)：
生物系薬学
, Biochemistry
Research theme for competitive and other funds (9)：
2007 - 2008 Alteration of endocytic pathway and lipid homeostasis in H_2O_2-induced apoptosis
1999 - 2000 低バイオアベイラビリティ医薬品の消化管吸収改善を目的とした新規配合剤の開発
1999 - 2000 Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.
1999 - 2000 Development of the strategy for the quantitative prediction and avoidance of drug-induced Parkinsonism based on pharmacokinetics and pharmacodynamics
Hideyasu Murakami, Airi Ohkura, Hitomi Takanaga, Hirotami Matsuo, Noriko Koyabu, Mikihiko Naito, Takashi Tsuruo, Hisakazu Ohtani, Yasufumi Sawada. Functional characterization of adenosine transport across the BBB in mice. International journal of pharmaceutics. 2005. 290. 1-2. 37-44
Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo, Mikihiko Naito, Takashi Tsuruo, Hisakazu Ohtani, Yasufumi Sawada. Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line. Drug metabolism and pharmacokinetics. 2004. 19. 4. 270-9
H Matsuo, K Funato, H Harashima, H Kiwada. The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ. JOURNAL OF DRUG TARGETING. 2003. 11. 5. 273-277
Chika Yamamoto, Hideyasu Murakami, Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo, Takeshi Uchiumi, Michihiko Kuwano, Mikihiko Naito, Takashi Tsuruo, Hisakazu Ohtani, et al. Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. The Journal of pharmacy and pharmacology. 2002. 54. 8. 1055-63
Run Tian, Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo, Hisakazu Ohtani, Yasufumi Sawada. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharmaceutical research. 2002. 19. 6. 802-9
C Jiang, H Matsuo, N Koyabu, H Ohtani, H Fujimoto, Y Yonemitsu, Y Kaneda, M Naito, T Tsuruo, Y Sawada. Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes. JOURNAL OF DRUG TARGETING. 2002. 10. 4. 345-352
A Ohnishi, H Matsuo, S Yamada, H Takanaga, S Morimoto, Y Shoyama, H Ohtani, Y Sawada. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. BRITISH JOURNAL OF PHARMACOLOGY. 2000. 130. 6. 1369-1377
JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
, THE BIOPHYSICAL SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
