Rchr
J-GLOBAL ID：200901035284244121
Update date: Apr. 14, 2024
Igarashi Kazuhiko
イガラシ カズヒコ | Igarashi Kazuhiko
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
http://www.biochem.med.tohoku.ac.jp/
,
http://www.biochem.med.tohoku.ac.jp/english/en_index.html
Research field (3)：
Molecular biology
, Pathobiochemistry
, Medical biochemistry
Research keywords (10)：
regulation of gene expression
, transcription factor
, chromatin
, S-adenosylmethionine
, iron
, heme
, cancer
, lymphoid cell differentiation
, hematopoiesis
, cell differentiation
Research theme for competitive and other funds (62)：
- 2022 - 2025 Elucidation of mechanisms in iron-driven pancreatic cancer cell metastasis
- 2020 - 2025 Development of anti-cancer strategy by exploiting BACH1 addiction
- 2018 - 2021 Elucidation of epigenetic regulation of erythropoiesis and translation to therapeutic strategy
- 2018 - 2021 Age-related alterations of hematopoietic stem and progenitor cells due to failure of Bach transcription factors
- 2017 - 2020 The effects of Bach 1 on skeletal muscle damage
- 2016 - 2019 The effect of BACH1 on malignant transformation of tumor
- 2016 - 2018 Development of a new strategy for tumor immunity activation
- 2015 - 2018 Regulation of erythropoiesis and macrophages by the heme signal
- 2014 - 2017 Novel molecular mechanism collaborating stem neural stem cell mainteinance and differentiation
- 2013 - 2016 Methods rewriting epigenome as the target of methyonine adenosyltransferase II
- 2011 - 2016 Crosstalk of transcriptional control and energy pathways by hub metabolites
- 2011 - 2016 Coupring mechanism of methionine metabolism and epigenome
- 2013 - 2015 Profiling of proteins associated with cell differentiation based on changes in relative abundance and post-translational modification.
- 2012 - 2015 Regulation of immune cells by heme and its receptors Bach1 and Bach2
- 2011 - 2013 Regulation of nuclear receptor activity by intracellular signals and ligands
- 2011 - 2012 Elucidation of the transcription factor network that regulates cancer-stroma interaction
- 2009 - 2011 Regulation of immune cell responses by heme
- 2004 - 2010 Promotion of Studies on the DECODE System in the Genetic Information Expression
- 2008 - 2009 ES細胞を用いた細胞記憶の改変技術の開発
- 2005 - 2009 Comparative Analysis of the DECODE Systems in Hematopoiesis and Oxidative Stress Response
- 2007 - 2008 Regulation of the tumor suppressor p53 by Bach1
- 2007 - 2008 Genetic ablation of transcription repressor Bach1 reduces neural tissue damage after spinal cord injury in mice
- 2005 - 2006 Control of cell proliferation and differentiation by heme bindiny transcription factor Bachl
- 2003 - 2004 Regulation of hematopoiesis by the transcription factors Bach1 and Bach2
- 2003 - 2004 Study of the mechanism of apoptosis and drug resistance in leukemic cells
- 2003 - 2004 ヘムオキシゲナーゼ1制御因子を標的とした虚血再潅流病態改善薬探索システムの開発
- 2002 - 2004 bach1/bach2二重ノックアウトマウスを用いたヘム応答性遺伝子制御システムの解析
- 2001 - 2004 Regulation of cell proliferation ancl apoptcsis by the nansaiption factois Bach1 and Bach2
- 2001 - 2003 Evaluation of toxicities of porphyrin derivatives and its possible application
- 2002 - 2002 核内オーファンプロテインネットワークの解明
- 2001 - 2002 Regulation of gene transcription and nuclear structure by architectural transcription factors
- 2001 - 2002 Cytogenetically analysis of congenital abnormality and childhood malignancy using multicolor FISH methods
- 2001 - 2001 核内オーファンプロテインネットワークの解明
- 1998 - 2001 転写調節による造血分化制御
- 2000 - 2000 Regulation of chromatin structures and hematopoietic cell differentiation by architectural transcription factors Bach1 and Bach2
- 2000 - 2000 Regulation of chromatin structures during hematopoietic cell differentiation
- 2000 - 2000 BTB型転写因子によるクロマチン構造と核内構造の共役
- 2000 - 2000 核内オーファンプロテインネットワークの解明
- 2000 - 2000 Bachファミリーによる細胞の増殖と死の制御
- 1998 - 2000 Nucleosome Structure-Function Relationship : Analyses by using atomic force microscopy
- 1999 - 1999 REGULATION OF CELL PROLIFERATION BY CROSS-TALK OF BACH AND AP-1 TRANSCRIPTION FACTORS.
- 1999 - 1999 NF-E2関連因子群によるクロマチン構造の制御と造血細胞分化における転写制御機構
- 1999 - 1999 造血細胞分化におけるNF-E2関連因子群の機能
- 1998 - 1999 Roles of heme in the regulation of gene expression and cell differentiation of erythroid cells
- 1998 - 1998 BachファミリーとAP-1のクロストークによる細胞増殖・分化の調節機構
- 1998 - 1998 グロビン遺伝子LCR結合因子によるクロマチン構造調節機構の解析
- 1998 - 1998 NF-E2結合配列を介した転写調節機構とその血液細胞分化における役割
- 1997 - 1998 GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATION
- 1997 - 1998 血球系転写因子NF-E2の活性調節機構の解析
- 1997 - 1998 REGULATION OF DIFFERENTIATION BY BACH TRANSCRIPTION FACTORS
- 1997 - 1997 新しい転写因子Bachファミリーと小Maf による細胞増殖分化の調節機構の解析
- 1997 - 1997 グロビン遺伝子LCR結合因子によるクロマチン構造調節機構の解析
- 1996 - 1996 小Maf因子群とCNC転写因子群とによる細胞増殖分化の調節機構の解析
- 1996 - 1996 グロビン遺伝子LCRの結合因子によるクロマチン構造調節機構の解析
- 1996 - 1996 新しい赤血球転写因子ECHによる転写制御機構の解析
- 1995 - 1995 転写因子群による赤血球特異的な遺伝子発現制御機序の解析
- 1995 - 1995 赤血球系転写因子群とMaf関連蛋白質による赤血球分化の制御とその異常の解析
- 1995 - 1995 グロビン遺伝子エンハンサーLCRによる活性化クロマチン構造の誘導機構
- 1995 - 1995 新しい赤血球特異的転写因子ECHとMaf関連蛋白質との会合による転写制御
- 1994 - 1994 転写因子群による赤血球特異的な遺伝子発現調節機序の解析
- 1994 - 1994 癌遺伝子mafの関連遺伝子産胸による赤血球系転写因子NF-E2の機能変換
- 1994 - 1994 赤血球特異的転写因子NF-E2とMaf関連蛋白質との会合による転写制御
Show all
Papers (319)：
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Kyoko Ochiai, Hiroki Shima, Toru Tamahara, Nao Sugie, Ryo Funayama, Keiko Nakayama, Tomohiro Kurosaki, Kazuhiko Igarashi. Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions. The EMBO Journal. 2024
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Liang Liu, Mitsuyo Matsumoto, Miki Watanabe-Matsui, Tadashi Nakagawa, Yuko Nagasawa, Jingyao Pang, Bert K.K. Callens, Akihiko Muto, Kyoko Ochiai, Hirotaka Takekawa, et al. TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. International Journal of Molecular Sciences. 2024
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Keisuke Tada, Hironari Nishizawa, Hiroki Shima, Akihiko Muto, Motoshi Wada, Kazuhiko Igarashi. Cysteine restriction induces ferroptosis depending on the polyamine biosynthetic pathway in hepatic cancer cells. 2024
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Suda A, Umaru BA, Yamamoto Y, Shima H, Saiki Y, Pan Y, Jin L, Sun J, Low YLC, Suzuki C, et al. Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth. Scientific reports. 2024
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Eduardo Pinheiro Amaral, Sivaranjani Namasivayam, Artur Trancoso Lopo de Queiroz, Fukutani E, Kerry Hilligan, Aberman K, Logan Fisher, Caio César Barbosa Bomfim, Keith Kauffman, Buchanan J, et al. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. Nature microbiology. 2023
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MISC (312)：
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新堀哲也, 永井康貴, 武藤哲彦, 林慶和, 阿部太紀, 五十嵐和彦, 青木洋子. Mutation related to MECOM-associated syndrome reduces hematopoietic stem and progenitor cells in mice. 日本小児科学会雑誌. 2024. 128. 2
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横山敦, 纐纈拓海, 尾坪優李, 沢津橋俊, 島弘季, 佐藤郁郎, 川村貞文, 鈴木貴, 五十嵐和彦, 菅原明. 核内受容体新規転写共役因子の探索. 日本アンドロロジー学会総会記事. 2022. 41st
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横山敦, 纐纈拓海, 尾坪優李, 沢津橋俊, 島弘季, 佐藤郁郎, 川村貞文, 鈴木貴, 五十嵐和彦, 菅原明. アンドロゲン受容体新規転写共役因子の探索. 日本アンドロロジー学会総会記事. 2022. 41st
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鈴木千恵, 鈴木千恵, 藤原亨, 藤原亨, 島弘季, 小野浩弥, 齋藤慧, 加藤浩貴, 小野寺晃一, 市川聡, et al. Elucidation of the role of FAM210B in mitochondrial metabolism in erythroblasts. 日本血液学会学術集会抄録(Web). 2021. 83rd
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加藤 浩貴, 五十嵐 和彦. 環境変化に応じた造血系の恒常性維持におけるBach因子群の役割. 臨床免疫・アレルギー科. 2019. 72. 5. 535-540
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Books (8)：
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特集RNAが修飾される! : エピトランスクリプトームによる生命機能と疾患の制御
羊土社 2018 ISBN:9784758125147
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シンプル生化学
南江堂 2014 ISBN:9784524268078
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イラストレイテッドハーパー・生化学
丸善出版 2013 ISBN:9784621087282
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遺伝情報の発現制御 : 転写機構からエピジェネティクスまで
メディカル・サイエンス・インターナショナル 2012 ISBN:9784895926973
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遺伝情報発現におけるDECODEシステム解明 : 研究成果報告書
[五十嵐和彦] 2011
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Education (2)：
- 1987 - 1991 Tohoku University Graduate School of Medicine
- 1981 - 1987 Tohoku University School of Medicine
Professional career (1)：
Committee career (1)：
Awards (4)：
- 2023/03 - KAKETSUKEN Toyoichi Ohtawara Award
- 2017/09 - Reviewer Award, Grant-in-Aid for Scientific Research
- 2006/03 - Japan Society for the Promotion of Science JSPS Prize
- 1996/10 - The Japanese Biochemical Society Young Investigator Award
Association Membership(s) (5)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, 日本生化学会(2006/10- 理事)
, American Society for Biochemistry and Molecular Biology
, 日本免疫学会
, 日本癌学会
