Rchr

J-GLOBAL ID：200901035418158812 Update date: Nov. 21, 2024

Nakayama Keiichi

ナカヤマケイイチ | Nakayama Keiichi

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://nakayama-lab.org/ , https://nakayama-lab.org/en/

Research field (3)： Immunology , Cell biology , Molecular biology

Research keywords (4)：細胞生物学 , 分子生物学 , Cell Biology , Molecular Biology

Research theme for competitive and other funds (65)：

2023 - 2026 幹細胞における時空間リプログラミングの機構解明と疾患との関わりの研究
2018 - 2023 幹細胞における細胞周期の制御と代謝系との連関に関する総合的研究
2017 - 2022 Trans-omic analysis of metabolic adaptation
2017 - 2018 がん細胞の代謝アダプテーション
2017 - 2018 代謝リモデリングによる適者生存メカニズムの研究

2015 - 2018 Epigenetic regulation of stem cell aging and organismal aging

2015 - 2018 Mechanism of PKD activation for monoamine release

2013 - 2018 幹細胞維持分子の機能解析と全身の幹細胞の可視化を目指した総合的研究

2016 - 2017 Elucidating the metabolic enzymes network in hypoxic cells using next-generation proteomics

2015 - 2017 新規モデルマウスを用いた自閉症マイクロエンドフェノタイプの解明

2015 - 2017 Elucidation of the mechanisms for Fbxw7 to suppress cancer metastasis in cancer niches

2015 - 2016 Deciphering the signal transduction pathway linking nutrition and inflammation

2013 - 2016 Elucidating the molecular mechanism of Warburg effect in cancer cells with iMRM

2013 - 2016 Method for determination of cellar pathway structure using multidimensional proteomics

2010 - 2016 Development of Novel Treatment Strategies Targeting Cancer Stem Cells

2014 - 2015 Elucidation of Warburg effect in cancer with the next-generation proteomics

2013 - 2015 Identification of an embryonic origin of adult neural stem cells

2012 - 2015 Elucidation of the mechanisms that control aging and cancer by chromatin remodeling

2010 - 2015 癌幹細胞の細胞周期制御機構の解明と治療法の開発

2013 - 2014 Functional analysis of a candidate gene for autism spectrum disorder

2010 - 2013 小胞輸送制御分子プロトルーディンの神経機能における役割の解明

2009 - 2011 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment.

2007 - 2011 Mechanisms of cell cycle arrest and its interaction with cell differentiation during development

2005 - 2010 タンパク質分解異常による発がん機構の研究

2005 - 2010 神経突起形成のマスター分子Protrudinの発見と機能解析

2009 - 2010 生殖細胞特異的クロマチン修飾因子の機能解析

2009 - 2010 高感度定量プロテオミクスを用いたユビキチンリガーゼ基質探索

2008 - 2010 神経機能調節におけるRabファミリーの制御機構

2008 - 2010 神経分化と機能制御における膜輸送の役割

2007 - 2008 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment

2007 - 2008 神経変性疾患における膜輸送システムの関与の解析

2006 - 2007 ProtrudinによるRabおよび膜輸送の制御機構の解析

2006 - 2007 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明

2006 - 2007 神経管形成における多機能シャペロンFKBP38の機能解析

2006 - 2007 リン酸化ペプチドの網羅的解析のための新技術開発

2005 - 2006 新規Cullin/Rbx型E3ユビキチンリガーゼ群の機能解析

2003 - 2005 発生工学プロテオミクスを用いたPKC-δシグナル伝達系の解明

2005 - 2005 神経突起伸長におけるFKBP38の機能解析

2005 - 2005 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明

2005 - 2005 中枢神経系領域形成におけるFKBP38の機能解析

2004 - 2005 細胞内タンパク質の特異的分解制御による癌に対する遺伝子治療法の確立

2004 - 2005 Analysis of degradation of cell cycle regulators Kip family

2004 - 2005 Comprehensive analysis of molecules related for antigen receptor signaling

2001 - 2005 Regulation of by protein degradation and transport.

2004 - 2004 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明

2003 - 2004 Study of molecular mechanisms of CD4 silencing and role s of Runx proteins during lymphocyte development

2003 - 2004 プロテアソームへのユビキチン化基質のターゲッテング機構の解析

2000 - 2004 Investigation into the molecular mechanisms underlying proteolysis of CDK inhibitor p27

2002 - 2002 プロテアソームへのユビキチン化基質のターゲッテング機構の解析

2001 - 2002 Establishment of therapeutic method for neurodegenerative diseases by specific protein degradation system for abnormal proteinsEstablishment of therapeutic method for neurodegenerative diseases by specific protein degradation system for abnormal proteins

2001 - 2002 New cancer therapy by degradation of specific proteins

2001 - 2002 New clearance system of abnormal protein in Polyglutammine disease

2001 - 2002 Axamノックアウトマウスの作製とその解析

2000 - 2001 Functional analysis of ubiquitin ligase by knock-out mise

1999 - 2001 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-_B AND MCP-1

1999 - 2000 Identification of the factors mediating ubiquitination of inclusion body in neurodegenerative diseases

1999 - 2000 細胞周期調節分子の分解制御に関する研究-マウスSCF複合体の遺伝子クローニングと解析-

1998 - 2000 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1

1998 - 1999 Regulation of degradation of p27Kip1, one of CDK inhibitory protein, for cancer therapy

1998 - 1999 Identification and functional analysis of S phase promoting complex in mammalian cell growth

1998 - 1998 細胞周期調節分子の分解制御に関する研究 - Yeast three-hybrid法の確立と応用 -

1998 - 1998 多角的戦略に基づく組換えアデノウィルスによる固形癌の遺伝子治療法の開発

1998 - 1998 サイクリン依存性キナーゼ阻害分子の分解機構の解明

1997 - 1998 Analysis of sinnalling pathway of apoptosis degradation using PKCδ gene-targeting mice

Investigation into the molecular mechanism of Cell-growth and Cell-death control

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Papers (490)：

Daisuke Koga, Shogo Nakayama, Tsunaki Higa, Keiichi I Nakayama. Identification and characterization of an enhancer element regulating expression of Cdkn1c (p57 gene). Genes to cells : devoted to molecular & cellular mechanisms. 2024
Saori Motomura, Kanae Yumimoto, Takeshi Tomonaga, Keiichi I Nakayama. CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation. Oncogene. 2024
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12
Toshiro Moroishi, Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongchot, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, et al. Hippo pathway in cancer cells modulates tumor microenvironment by inducing immunosuppressive NCAM1+αSMA+ fibroblasts. Research Square. 2024
Miyuki Nomura, Mai Ohuchi, Yoshimi Sakamoto, Kei Kudo, Keisuke Yaku, Tomoyoshi Soga, Yuki Sugiura, Mami Morita, Kayoko Hayashi, Shuko Miyahara, et al. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nature communications. 2023. 14. 1. 8095-8095

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MISC (36)：

松本有樹修, 市原知哉, 西田紘士, 今見考志, 石濱泰, 中山敬一. Combinatorial analysis of translatome and proteome unveils the importance of hidden ORFs. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
市原知哉, 松本有樹修, 西田紘士, 今見孝志, 石濱泰, 中山敬一. Molecular mechanism and biological significance of non-AUG translation initiation revealed by precise identification of translation initiation sites. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
松崎芙美子, 松本雅記, 中山敬一. がん代謝. がん分子標的治療. 2014. 12. 2. 175-180
Surveys for mTOR Targets by Proteomic Analysis. 2012. 31. 12. 1360-1367
Proteomics for the study on cell cycle regulation. Cell technology. 2009. 28. 1. 59-64

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Education (4)：

1986 - 1990 Juntendo University
- 1990 Juntendo University Graduate School, Division of Medicine
1980 - 1986 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- 1986 Tokyo Medical and Dental University Faculty of Medicine

Professional career (1)：

(BLANK)

Work history (8)：

2024/10 - 現在 Institute of Science Tokyo Laboratory of Anticancer Strategies, Advanced Research Initiative Professor
2023/04 - 2024/09 Tokyo Medical and Dental University Laboratory of Anticancer Strategies, TMDU Advanced Research Institute Professor
2009/10 - 2024/03 Kyushu University Medical Institute of Bioregulation
1996/10 - 2009/04 Kyushu University Medical Institute of Bioregulation
1995/07 - 1996/09 (株)日本ロシュ研究所主幹研究員

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Committee career (2)：

2005 - 2006 日本分子生物学会評議員
2005 - 日本癌学会評議員

Awards (9)：

2022/11 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Mochida Memorial Award
2021/03 - Medal with Purple Ribbon
2018/12 - Yasuda Medical Prize
2018/06 - Kobayashi Foundation for Cancer Research Kobayashi Foundation Cancer Science Award
2011/02 - 第27回井上学術賞細胞周期制御因子のユビキチン依存性分解に関わる研究

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Association Membership(s) (5)：

日本プロテオーム学会 , 日本癌学会 , 日本分子生物学会 , 日本癌学会 , 日本分子生物学会

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