Rchr
J-GLOBAL ID:200901036408706842
Update date: Sep. 09, 2024
Nakajo Koichi
ナカジョウ コウイチ | Nakajo Koichi
Affiliation and department:
Homepage URL (1):
http://www.jichi.ac.jp/physio2/index.html
Research field (3):
Physiology
, Neuroscience - general
, Biophysics
Research keywords (10):
KCNQチャネル
, Kv4 channel
, HCNチャネル
, zebrafish
, voltage-gated ion channel
, electrophysiology
, voltage sensor
, potassium channels
, ion channels
, single molecule imaging
Research theme for competitive and other funds (15):
- 2024 - 2027 Understanding of the Kv/HCN channel gating mechanism based on structural information
- 2021 - 2024 生体中のイオンチャネル複合体の分子構成検出と生理機能解明
- 2017 - 2020 心臓におけるKCNQ1チャネル修飾サブユニットの機能解明
- 2017 - 2018 KCNQ1カリウムチャネルの腎臓における機能と慢性腎臓病との関連の解明
- 2016 - 2018 心臓におけるイオンチャネル複合体形成とその制御機構の解明
- 2014 - 2017 Analysis of the voltage dependence of Gq coupled receptors
- 2014 - 2017 Sensing, processing and neurotransmission of taste in the taste buds
- 2013 - 2015 ストイキオメトリーの違いを考慮したKCNQ1チャネル活性化機構の光生理学的解析
- 2012 - 2015 KCNQ1-KCNE1イオンチャネル複合体の結合状態と電流キネティクスの関係
- 2012 - 2014 Functional expression of mammalian ion channels and analysis of the molecular mechanisms
- 2011 - 2013 ストイキオメトリーの多様性を考慮に入れた新しい心筋カリウムチャネルモデルの確立
- 2010 - 2012 Detection of state-dependent change of the stoichiometry of KCNQ1-KCNE1 complex by single molecule imaging
- 2008 - 2009 Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue
- 2006 - 2007 KCNQ1チャネルのKCNE1会合による活性化遅延機構の電気・光生理学的解析
- 1999 - 2001 CDNA発現系を用いた筋発生におけるカルシウムチャネルの機能的局在機構の解明
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Papers (37):
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Alessandro Porro, Edoardo Armano, Federico Brandalise, Rebecca Appiani, Monica Beltrame, Andrea Saponaro, Clelia Dallanoce, Koichi Nakajo, Kaei Ryu, Roberta Leone, et al. A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo. Journal of medicinal chemistry. 2024
-
Koichi Nakajo, Go Kasuya. Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains. Physiological Reports. 2024
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Daichi Yamanouchi, Go Kasuya, Koichi Nakajo, Yoshiaki Kise, Osamu Nureki. Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex. Molecular Cell. 2023
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Go Kasuya, Koichi Nakajo. Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex. eLife. 2022
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Jiaying Liu, Go Kasuya, Buntaro Zempo, Koichi Nakajo. Two HCN4 Channels Play Functional Roles in the Zebrafish Heart. Frontiers in Physiology. 2022. 13
more...
MISC (24):
Books (1):
-
ガイトン生理学 原著第13版
エルゼビア・ジャパン 2018
Lectures and oral presentations (4):
-
Regulation of KV7.1 channel by KCNE proteins
(Ion Channel Modulation Symposium - UK 2024 2024)
-
Gating Modulation of KCNQ1 Channels by KCNE Subunits: A Structure-guided Approach
(The 9th International Ion Channel Conference)
-
A role of the S1 segment in KCNQ1 modulation by KCNE
(Kv7 Channels Symposium 2023 2023)
-
Gating modulation via voltage-sensing domains in voltage-gated K+ channels
(Ion Channel Modulation Symposium 2023 - JAPAN 2023)
Education (3):
- 1997 - 2002 The University of Tokyo
- 1994 - 1997 The University of Tokyo College of Arts and Sciences Department of Basic Science
- 1992 - 1994 The University of Tokyo College of Arts and Sciences
Professional career (1):
Work history (9):
- 2018/04 - 現在 Jichi Medical University Division of Integrative Physiology Professor
- 2015/03 - 2018/03 Osaka Medical College Department of Physiology Associate Professor
- 2005/11 - 2015/02 SOKENDAI Department of Physiological Sciences Assistant Professor
- 2005/04 - 2015/02 National Institute for Physiological Sciences Division of Biophysics and Neurobiology Assistant Professor
- 2008/09 - 2009/03 UC Berkeley Visiting researcher
- 2004/04 - 2005/03 National Institute for Physiological Sciences Division of Biophysics and Neurobiology Postdoc
- 2002/04 - 2004/03 Tokyo Medical and Dental Univ Postdoc
- 1999/04 - 2002/03 学術振興会特別研究員(DC1)
- 1999/06 - 1999/09 Case Western Reserve Univ. Visiting scholar
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Committee career (6):
- 2024/04 - 現在 日本生理学会 理事
- 2024/04 - 現在 日本生理学会 会員委員会委員長
- 2022/04 - 現在 日本生理学会 研究倫理委員会委員
- 2022/04 - 現在 日本生理学会 会員委員会委員
- 2018/09 - 2019/03 FAOPS2019 JGP poster award 選考委員長
- 日本生理学会 評議員
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Awards (2):
- 2014/06 - 自然科学研究機構 第3回若手研究者賞
- 2010/08 - 日本生理学会 平成22年度 入澤宏・彩記念若手研究奨励賞日本生理学会奨励賞
Association Membership(s) (4):
PHYSIOLOGICAL SOCIETY OF JAPAN
, THE BIOPHYSICAL SOCIETY OF JAPAN
, Biophysical Society
, 日本神経科学学会
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