Research keywords (5)：
Vitamin
, prodrug
, pharmaceutics
, radiopharmaceutical
, drug delivery system
Research theme for competitive and other funds (2)：
2002 - 2004 イソプレニル基を有するビタミン類の誘導体化による新規治療薬の開発
2001 - 2002 The labeling design of saccharides and its functional pharmaceuticals (2002)
Papers (48)：
Shotaro Goto, Shuichi Setoguchi, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Koichi Matsuo, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata. Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors. Scientific Reports. 2023. 13. 1
Mariko Hirano-Kusuda, Shuichi Setoguchi, Mitsuhisa Koga, Shotaro Goto, Ayano Yamada, Daisuke Watase, Nami Nagata-Akaho, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata. Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption. Pharmaceutical Research. 2023
Erina Toki, Shotaro Goto, Shuichi Setoguchi, Kazuki Terada, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Kaori Kubota, Katsunori Iwasaki, et al. Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death. Scientific Reports. 2022. 12. 1
Watase D, Setoguchi S, Nagata-Akaho N, Goto S, Yamakawa H, Yamada A, Koga M, Karube Y, Matsunaga K, Takata J. Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion. Molecules. 2022. 27. 9. 2727-2727
Hirofumi Yamakawa, Shuichi Setoguchi, Shotaro Goto, Daisuke Watase, Kazuki Terada, Nami Nagata-Akaho, Erina Toki, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, et al. Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line. Pharmaceutics. 2021. 13. 5
Chika Ogami, Yasuhiro Tsuji, Hidefumi Kasai, Yoshihiro Yamamoto, Kazuhisa Matsunaga, Yoshiharu Karube, Hideto To. Instability of daptomycin in serum at various temperatures may affect its pharmacokinetics. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2017. 50. S75-S76
Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma
(International Drug Discovery Science and Technology Japan 2017 (Osaka) 2017)
- 1998 Kyushu University Graduate School, Division of Pharmaceutical Sciences 医療薬学
- 1993 Fukuoka University Faculty of Pharmaceutical Science 薬学科
Professional career (1)：
博士(薬学) (九州大学)
Work history (5)：
2019/04/01 - 福岡大学薬学部教授
2010/03 - 2011/03 Baylor College of Medicine visiting research fellow
2007/04/01 - 福岡大学薬学部准教授
1999/04/01 - 福岡大学薬学部助手
1998/04/01 - 1999/03/31 九州大学医学部附属病院薬剤部薬剤師
Committee career (3)：
2021/06 - 現在 日本ビタミン学会 幹事
2021/02 - 現在 日本薬学会 代議員
2015/11 - 2021/05 日本ビタミン学会 代議員
Association Membership(s) (4)：
The Academy of Pharmaceutical Science and Technology, Japan
, The Vitamin Society of Japan
, Japanese Cancer Association
, The Pharmaceutical Society of Japan
