Rchr
J-GLOBAL ID：200901036522954988   Update date: Sep. 14, 2024

Koike Tohru

コイケ トオル | Koike Tohru
Affiliation and department：
Hiroshima University

About Hiroshima University


Research field  (1)： Pharmaceuticals - analytical and physicochemistry
Research keywords  (2)： Thio-tag Technology ,  Phos-tag Technology
Research theme for competitive and other funds  (37)：
  • 2020 - 2023 Screening of post-translational modified molecules by using functional zinc complexes
  • 2017 - 2019 亜鉛イオンの特性を利用した不安定リン酸化シグナルの蛍光分析法
  • 2014 - 2016 Analysis of phosphorylation signal using a Phos-tag quencher
  • 2010 - 2013 Analytical methods for protein kinase profiling by using fluorescent Phos-tag molecules
  • 2007 - 2009 Development of novel analytical methods for phosphoproteomics by using a phosphate-binding tag molecule.
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Papers (216)：
  • Emiko Kinoshita-Kikuta, Kaku Shimoji, Kento Hiraishi, Kento Nishikawa, Kenichi Nagase, Tohru Koike, Eiji Kinoshita. Characterization of constitutively hyperphosphorylated lamin A <i>in vivo</i> using Phos-tag SDS-PAGE. Journal of Electrophoresis. 2024. 68. 1. 1-6
  • Ichimaru, Yoshimi, Kato, Koichi, Sugiura, Kirara, Isomura, Risa, Fujioka, Haruto, Koike, Tohru, Fujii-Kishida, Sayuri, Kurihara, Masaaki, Yamaguchi, Yoshihiro, Jin, Wanchun, et al. Artificial helix supramolecule by doubly p-xylyl bridged bis(ZnII-cyclen) (cyclen=1,4,7,10-tetraazacyclododecane). INORGANIC CHEMISTRY COMMUNICATIONS. 2023. 153
  • Use of Escherichia coli expression system for analyzing kinase motifs. Journal of Electrophoresis. 2022. 66. 13-20
  • Ichimaru, Yoshimi, Kato, Koichi, Sugiura, Kirara, Hirata, Chisa, Jin, Wanchun, Fujioka, Haruto, Kurosaki, Hiromasa, Koike, Tohru. Crystal Structure of [{m,m-bis(Zn-II-cyclen)}(3)(mu(2)-CO3)(2)(H2O)(2)](ClO4)(8)center dot nH(2)O. X-RAY STRUCTURE ANALYSIS ONLINE. 2022. 38. 53-55
  • Kinoshita-Kikuta, Emiko, Koike, Tohru, Kinoshita, Eiji. Recent advances in the Phos-tag technique focused on the analysis of phosphoproteins in a bacterial two-component system. JOURNAL OF PROTEOMICS. 2022. 252
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MISC (8)：
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Patents (35)：
  • METHOD FOR IDENTIFYING MOLECULAR WEIGHT OF A PHOSPHORIC ACID MONOESTER COMPOUND AND AN ADDITIVE FOR MASS SPECTROMETRY
  • A capturing agent for a substance having an anionic substituent
  • リン酸モノエステル化合物の分子量を求める方法、およびマススペクトル測定用添加剤
  • METHOD FOR IDENTIFYING MOLECULAR WEIGHT OF A PHOSPHORIC ACID MONOESTER COMPOUND AND AN ADDITIVE FOR MASS SPECTROMETRY
  • リン酸モノエステル化合物の分子量を求める方法、およびマススペクトル測定用添加剤
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Books (13)：
  • ATM kinase: Methods in Molecular Biology
    Humana Press, Springer Science, New York 2017 ISBN:9781493969555
  • Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field
    2016
  • "Protein Modifications in PathogenicDysregulation of Signaling, Edited by J. Inoue and M. Takekawa: "Phos-tag-Based Affinity ChromatographyTechniques for Enrichmentof the Phosphoproteome"
    Springer Japan 2015 ISBN:9784431555605
  • Proteomic Profiling: Methods in Molecular Biology, Edited by Anton Posch, Chapter 24: Neutral Phosphate-Affinity SDS-PAGE System for Profiling of Protein Phosphorylation
    Humana Press, Springer Science, New York 2015 ISBN:9781493925506
  • Phos-tag ゲルによるリン酸化タンパク質の分離・同定法.臨床プロテオミクス~バイオマーカー探索から個別化医療へ
    金原出版 2012 ISBN:9784307004701
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Lectures and oral presentations  (63)：
  • STYK1を介した腫瘍形成に伴うがん悪性化機構の解析
    (日本電気泳動学会71回総会 2020)
  • チロシンキナーゼ Lyn は細胞膜への輸送の過程でゴルジ体においてcasein kinase 1γによってセリン13がリン酸化される
    (日本生化学会大会第93回 2020)
  • Phos-tag蛍光ゲル染色剤を用いた細菌の2成分伝達系のHis /Asp定量的リン酸化解析
    (日本生化学会大会第93回 2020)
  • 蛍光Phos-tag誘導体によるブロット膜上のリン酸化タンパク質の定量解析法の開発
    (日本生化学会大会第93回 2020)
  • Phos-tag蛍光ゲル染色剤を用いたバクテリア2成分系シグナルの定量モニタリング
    (第42回日本分子生物学会年会 2019)
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Work history (8)：
  • 2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
  • 2012/04/01 - 2019/03/31 Hiroshima University Institute of Biomedical & Health Sciences Professor
  • 2002/04/01 - 2012/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
  • 1999/04/01 - 2002/03/30 Hiroshima University Professor
  • 1998/09/01 - 1999/03/31 Hiroshima University Faculty of Medicine Professor
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Awards (3)：
  • 2014 - 広島大学 広島大学 学長表彰
  • 2011/03/11 - 医歯薬学総合研究科 広島大学大学院 医歯薬学総合研究科教員表彰
  • 広島大学 医歯薬学総合研究科「教員表彰 (教育部門)」
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