Suzuki Toyofumi

スズキトヨフミ | Suzuki Toyofumi

Affiliation and department：
Job title： Professor

Research field (4)： Clinical pharmacy , Clinical pharmacy , Clinical pharmacy , Clinical pharmacy

Research keywords (14)： Drug Delivery to the Brain , Nose-to-Brain , Blood-Brain Barrier Transport , Intranasal formulations , Nasal spray formulation / Nasal powder formulation , 経鼻吸収 , Cerebral Ischemia , cerebral ischemic reperfusion injury , transdermal therapeutic system , 容器回転撹拌型連続造粒 , Drug Absorption , Syrup for Infants , 半固形製剤 , Orally disintegrating tablet

Research theme for competitive and other funds (23)：

2025 - 2028 Searching for a rescue method by intranasal drug combination therapy aiming at neuroprotection against acute cerebral infarction
2024 - 2027 Intranasal administration of lamotrigine containing nano co-crystals for brain transport and therapeutic effect on epilepsy
2019 - 2021 鼻から脳への薬物移行経路を介した経鼻投与製剤の基盤技術の開発と中枢疾患治療戦略
2017 - 2020 脳神経系希少疾患治療を目指した経鼻投与による脳内バイオ医薬デリバリー戦略の構築
2018 - 2019 薬物封入ナノキャリアが虚血性脳梗塞急性期における脳神経保護効果に及ぼす影響

2018 - 2018 脳松果体から分泌される中分子ペプチドホルモン・メラトニンの鼻から脳への薬物送達とその移行経路の解明

2017 - 2018 虚血性脳梗塞に対する薬物の経鼻投与経路の有用性

2013 - 2015 皮膚老化の進行過程を抑制するための抗酸化作用を有する物質の皮内送達法の探索

2013 - 2014 グルタミン酸受容体及び酸感受性イオンチャネルを分子標的としたビグアニド誘導体の新規脳機能保護薬としての有用性

2011 - 2012 NMDAR及びASICを分子標的とした脳梗塞改善薬の開発研究

2010 - 2012 老化を基礎とする疾患の発症・進展の予防を目的とした薬物の脳内移行特性の解明と応用

2009 - 2010 血液脳関門におけるアミノ酸輸送に及ぼす脳虚血/再灌流障害の影響

2008 - 2010 エプタゾシン等の経皮吸収剤化に関する研究

2008 - 2009 一過性脳虚血障害による血液脳関門破綻の蛍光イメージング

2007 - 2008 麻薬拮抗薬の血液脳関門取り込み輸送に関わる有機カチオントランスポーターの役割

2006 - 2007 薬物輸送担体を利用した非麻薬性鎮痛薬の鎮痛作用増強に関する研究

2005 - 2007 アポトーシス誘導型新規化学療法の検索:抗がん剤に抵抗性を獲得したヒトがん細胞に対して

2005 - 2006 麻薬拮抗性鎮痛薬の血液脳関門排出における輸送担体の関与

2001 - 2002 Development of non-oral type sustained release formulation for pain control

2000 - 2002 Development of the antibacterial biomaterial for the clinical use

2000 - 2001 Distribution control and transport mechanism of the basic drugs across the blood-brain barrier

2000 - 2001 Development of non-oral pharmaceutical formulation for the management of cancer-related and postoperative pain

1998 - 1999 Kinetic analysis of the transport mechanism of pentazocine across the blood-brain barrier

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Papers (133)：

Yasuhito Nobushi, Kazuo Uchikura, Fumiyuki Watanabe, Toyofumi Suzuki, Hiromichi Asamoto. Determination of 1-deoxynojirimycin by hydrophilic interaction liquid chromatography with tris (2,2’-bipyridine) ruthenium (II)-electrogenerated chemiluminescence detection. Salt and Seawater Science & Technology. 2025. 6. 29-34
So Iwabuchi, Toru Imai, Naoto Suzuki, Hiroshi Nango, Taiki Nagatomo, Hiroko Miyagishi, Toyofumi Suzuki, Susumu Ootsuka, Yasuhiro Kosuge. Comparative evaluation of amiodarone and furosemide compatibility under different mixing conditions. Scientific Reports. 2025. 15. 1
Taiki Nagatomo, Kanon Nagasawa, Yuiko Kanbara, Naoto Suzuki, Toyofumi Suzuki. Impact of using amorphous solid dispersions on brain and systemic delivery of intranasally administered phenytoin. Journal of Drug Delivery Science and Technology. 2025. 111. 107122
Hiroshi Nango, Ai Takahashi, Naoto Suzuki, Takumi Kurano, Saia Sakamoto, Taiki Nagatomo, Toyofumi Suzuki, Takanori Kanazawa, Yasuhiro Kosuge, Hiroko Miyagishi. Therapeutic efficacy of intranasal N-acetyl-L-cysteine with cell-penetrating peptide-modified polymer micelles on neuropathic pain in partial sciatic nerve ligation mice. Pharmaceutics. 2025. 17. 44
Taiki Nagatomo, Mihiro Kanai, Mitsuyoshi Fukuda, Manabu Shimazaki, Yoshihisa Yamamoto, Naoto Suzuki, Kaname Hashizaki, Toyofumi Suzuki. Quantitative relationship between the viscosity of pediatric syrups containing ambroxol hydrochloride and the adhesive remaining amount in the metering glass. The Journal of Community Pharmacy and Pharmaceutical Sciences. 2025. 17. 1. 1-12

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MISC (141)：

宮岸寛子, 金沢貴憲, 藏野匠, 鈴木直人, 鈴木豊史, 小菅康弘. Therapeutic effects of N-acetyl-L-cysteine by intranasal administration combined with cell-penetrating peptide-modified polymer micelles in mouse models of neuropathic pain. 日本薬学会年会要旨集(Web). 2024. 144th
飯岡真吾, 金沢貴憲, 藏野匠, 小菅康弘, 鈴木豊史, 近藤啓. Therapeutic effects by siRNA-loaded Nose-to-Brain micelles in ALS model mice. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
藏野匠, 渋市梨子, 鶴田こむぎ, 村山弘樹, 山崎海斗, 小菅康弘, 小菅康弘, 鈴木豊史, 鈴木豊史, 金沢貴憲, et al. Improvement of distribution in the spinal cord and life-prolongation effect in ALS model mice by intranasal administration of NAC combined with cell-penetrating peptide-modified polymer micelles. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
鈴木豊史, 鈴木直人, 橋崎要, 長友太希, 柳侑里, 金沢貴憲. Quantitative evaluation of the nasal retention of temperature-sensitive in situ gel using 3D human nasal cavity model. 日本薬学会年会要旨集(Web). 2020. 140th
鶴田こむぎ, 藏野匠, 浅山涼, 吉野正洋, 山口真侑, 鈴木直人, 和田平, 小菅康弘, 榛葉繁紀, 鈴木豊史, et al. 細胞透過性ペプチド修飾高分子ミセル併用経鼻投与によるsiRNAの筋萎縮性側索硬化症マウスにおける脊髄内分布と標的mRNA発現抑制効果. 日本薬学会関東支部大会講演要旨集. 2020. 64th

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Patents (23)：

Pharmaceutical composition for external use (Canada)
Pharmaceutical composition for external use (South Korea)
外用医薬組成物を用いた貼付剤
Matrix-type patch preparation and method for producing same (Taiwan)
Externally-applied medicinal composition (China)

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Books (14)：

Biopharmaceutics <4th Edition>
2025 ISBN:9784524404827
Physical pharmaceutics
Kyoto Hirokawa Publishing INC. 2025 ISBN:9784910844558
臨床製剤学[電子版付]改訂第5版増補
南江堂 2025 ISBN:9784524404926
新規モダリティ医薬品のための新しいDDS技術と製剤化
Technical Information Institute Co., Ltd. 2023 ISBN:9784861049361
コンパス生物薬剤学[電子版付]改訂第3版増補
南江堂 2022 ISBN:9784524404520

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Lectures and oral presentations (672)：

酢酸亜鉛投与症例の有効性に影響を及ぼす病態背景および栄養状態の調査研究[22-12-O16-5]
(第35回日本医療薬学会年会(神戸) 2025)
連続混合造粒機「LaVortex G」を用いた医薬品原料の連続混合能力と装置内滞留時間の評価[一般講演1]
(第42回製剤と粒子設計シンポジウム(新潟) 2025)
脂肪酸類がイオン液体介在ミセルの形成と可溶化能に及ぼす影響[P-140pm]
(第69回日本薬学会関東支部大会(日本薬大) 2025)
コリン/オレイン酸イオン液体の経鼻製剤化に向けたモル比率および噴霧特性の評価[P-138pm]
(第69回日本薬学会関東支部大会(日本薬大) 2025)
脳梗塞急性期に対するコハク酸エチルメチルヒドロキシピリジンの経鼻投与による脳移行性とその神経保護効果[P-135pm]
(第69回日本薬学会関東支部大会(日本薬大) 2025)

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Professional career (1)：

博士(薬学) (日本大学)

Work history (4)：

2016/04 - 現在 School of Pharmacy, Nihon University Laboratory of Pharmaceustics Professor
2011/04 - 2016/03 School of Pharmacy, Nihon University Laboratory of Pharmaceutics Associate Professor
2004/04 - 2011/03 School of Pharmacy, Nihon University Laboratory of Pharmaceutics Lecturer
2002/08 - 2003/09 University of California at Los Angeles (UCLA), School of Medicine Department of Medicine/Endocrinology (Prof. Pardridge) Postgraduate Scientist (Visiting Researcher)

Committee career (14)：

2024/04 - 現在 The Pharmaceutical Society of Japan Section Editor-in-Chief, The Editorial Committee of the Pharmaceutical Society of Japan
2019/02 - 現在 The Pharmaceutical Society of Japan 代議員
2018/04 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) 代議員
2022/04 - 2025/03 Japan Accreditation Board for Pharmaceutical Education 2022-2024 Evaluation Team Evaluation Member
2020/04 - 2025/03 Ministry of Health, Labour and Welfare The 106-110th Pharmacist National Examination, Pharmacy Examination Board

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Awards (6)：

2021/09 - Japan Oil Chemists' Society The 20th Japan Oil Chemists' Society, Oleo Science Transport Mechanism in the Nose-to-Brain Drug Delivery and Role of Nanosystems
2017/10 - The 50th
2010/10 - 2010
2006/07 - The APSTJ Global Education Seminar The APSTJ Global Education Seminar Presentation Award 2006 Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology
2005/06 - The Journal of Nuclear Medicine Editor's Selection Award 2004 (Outstanding Basic Science Investigation) from The Journal of Nuclear Medicine

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Association Membership(s) (5)：

Academy of Pharmaceutical Science and Tschnology of Japan (APSTJ) , The Japanese Society for the Study of Xenobiotics (JSSX) , The Pharmacutical Society of Japan#9305569 , 日本DDS学会 , The Japanese Society of Clinical Pharmacology and Therapeutics

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