Rchr
J-GLOBAL ID：200901036721878492   Update date: Apr. 23, 2024

Maehama Tomohiko

Maehama Tomohiko
Research field  (4)： Functional biochemistry ,  Pathobiochemistry ,  Molecular biology ,  Cell biology
Research keywords  (8)： PTEN ,  PICT1 ,  nucleolar stress ,  シグナル伝達 ,  tumor suppressor ,  tumor ,  signal transduction ,  phosphoinositide
Research theme for competitive and other funds  (31)：
  • 2024 - 2027 PICT1を起点とする核小体ストレス応答機構の全貌解明
  • 2022 - 2025 癌抑制ドライバー経路を標的とする抗癌剤開発
  • 2019 - 2021 リボソームタンパク質を標的とした新規p53活性化薬剤の探索
  • 2018 - 2021 Study of PICT1-mediated nucleolar stress response and tumorigenesis
  • 2018 - 2019 p53活性化新規抗がん薬の探索
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Papers (74)：
  • Tomohiko Maehama, Miki Nishio, Junji Otani, Tak Wah Mak, Akira Suzuki. Nucleolar stress: Molecular mechanisms and related human diseases. Cancer science. 2023
  • Yusuke Shiraishi, Tomohiko Maehama, Miki Nishio, Junji Otani, Hiroki Hikasa, Tak Wah Mak, Takehiko Sasaki, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, et al. N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ. GENES TO CELLS. 2022. 27. 10. 602-612
  • Yuntao Dai, Tetsuya Kawaguchi, Miki Nishio, Junji Otani, Hironori Tashiro, Yoshito Terai, Ryohei Sasaki, Tomohiko Maehama, Akira Suzuki. The TIGD5 gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor. GENES TO CELLS. 2022
  • Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P. Lydon, et al. Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022. 119. 29
  • Yusuke Shiraishi, Tomohiko Maehama, Miki Nishio, Masato Fujisawa, Akira Suzuki. A carbazole compound affects Hippo signaling pathway and represses bladder cancer cell proliferation. CANCER SCIENCE. 2022. 113. 1629-1629
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MISC (25)：
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Lectures and oral presentations  (30)：
  • 動物モデルによる先端がん研究 Hippoシグナルによるがんの発症進展制御
    (日本生化学会大会プログラム・講演要旨集 2021)
  • Hippo-YAP signaling pathway in squamous cell carcinoma onset and progression
    (The 5th UW-KU International Joint Symposium 2021)
  • Hippo経路を標的として膀胱がん細胞の増殖を抑制する新規化合物の同定
    (日本癌学会総会記事 2021)
  • Basal like乳癌におけるHippo経路の役割
    (日本癌学会総会記事 2021)
  • Hippo-YAP signaling pathway in squamous cell carcinoma onset and progression
    (The 39th Sapporo International Cancer Symposium 2021)
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Education (2)：
  • 1990 - 1995 東京工業大学大学院 生命理工学研究科
  • 1986 - 1990 Tokyo Institute of Technology Faculty of Science
Work history (6)：
  • 2024 - 現在 Showa University Department of Biochemistry, School of Medicine Professor
  • 2016 - 2024 Kobe University Graduate School of Medicine Associate Professor
  • 2006 - 2016 National Institute of Infectious Diseases Department of Biochemistry and Cell Biology Laboratory Chief
  • 2000 - 2006 Tokyo Metropolitan Institute of Medical Science Department of Pharmacology Researcher
  • 1997 - 1999 University of Michigan Medical School Research Fellow
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Association Membership(s) (4)：
日本癌学会 ,  The Molecular Biology Society of Japan ,  日本プロテインホスファターゼ研究会 ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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