Maehama Tomohiko

Research field (4)： Functional biochemistry , Pathobiochemistry , Molecular biology , Cell biology

Research keywords (8)： PTEN , PICT1 , nucleolar stress , シグナル伝達 , tumor suppressor , tumor , signal transduction , phosphoinositide

Research theme for competitive and other funds (20)：

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Papers (80)：

Junji Otani, Miki Nishio, Riko Tokita, Hiroki Hikasa, Makoto Nishimori, Shingo Dan, Isao Naguro, Hidenori Ichijo, Masanori Miyanishi, Takehiko Sasaki, et al. SAMD4 represses VGLL4 mRNA to activate TEAD and promote cancer progression. Oncogene. 2026
Uchiyama J, Shimizu Y, Unoki T, Kasamatsu S, Ida T, Ihara H, Kim YG, Hase K, Miura Y, Maehama T, et al. Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides. Redox biology. 2026. 92. 104123-104123
Misaki Kosaka*, Yoshimi Okamoto-Uchida*, Haruka Hirose*, Yuya Nagaoka, Norio Miyamura, Akinori Kanai, Daiki Hatakeyama, Michiko Nakagawa, Miki Nishio, Tomohiko Maehama, et al. Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations. 2025
Miki Nishio, Keiko Yamaguchi, Junji Otani, Katsuya Yuguchi, Daisuke Kohno, Tsutomu Sasaki, Tadahiro Kitamura, Masakazu Shinohara, Tomoyoshi Soga, Koichi Kawamura, et al. MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes. Proceedings of the National Academy of Sciences of the United States of America. 2025. 122. 17. e2424741122
Tomohiko Maehama, Miki Nishio, Junji Otani, Tak Wah Mak, Akira Suzuki. Nucleolar stress: Molecular mechanisms and related human diseases. Cancer science. 2023

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MISC (27)：

前濱朝彦, 西尾美希, 鈴木聡. 核小体ストレスによる細胞死と病態. 医学のあゆみ. 2022. 283. 396-402
前濱朝彦, 西尾美希, 鈴木聡. 【細胞競合による生体制御とがん】細胞競合とがん哺乳類Hippo経路による細胞接着の制御と細胞競合. 医学のあゆみ. 2020. 274. 5. 457-462
前濱朝彦. PICT1を起点としたリボソームホメオスタシス制御機構の解明. 日本応用酵素協会誌. 2017. 51. 59-60
The role of Hippo-YAP/TAZ signaling in mechanotrasduction and tumorigenesis. 2016. 67. 2. 127-131
前濱朝彦, 鈴木聡. 【脂質疾患学なぜ"あぶら"の異常が病気を引き起こすのか?その質的量的変化と肥満、がん、不妊症、免疫・皮膚・神経疾患】 (第2章)多彩な疾患における脂質の量的・質的変化がん PTEN 脂質ホスファターゼとしての機能と発がんへの関与. 実験医学. 2015. 33. 15. 2479-2485

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Lectures and oral presentations (47)：

核小体ストレス経路を標的とした新規抗がん薬の開発
(第48回日本分子生物学会年会 2025)
Adipocyte-specific MOB1 deficiency improves high-fat diet-induced obesity and glucose metabolism
(第98回日本生化学会大会 2025)
転写後調節によるHippo-YAP経路の制御
(第84回日本癌学会学術総会 2025)
核小体ストレス経路を標的とした新規抗がん薬の開発
(第84回日本癌学会学術総会 2025)
選択的スプライシングを起点としたマクロファージにおける血管新生調節機構の解明
(日本生化学会関東支部例会 2025)

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Education (2)：

Work history (8)：

2024 - 現在 Showa Medical University Research Center for Biochemistry Professor
2024 - 現在 Kobe University
2024 - 現在 Showa Medical University Department of Biochemistry, School of Medicine Professor
2016 - 2024 Kobe University Graduate School of Medicine Associate Professor
2006 - 2016 National Institute of Infectious Diseases Department of Biochemistry and Cell Biology Laboratory Chief

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Association Membership(s) (4)：

日本癌学会 , The Molecular Biology Society of Japan , 日本プロテインホスファターゼ研究会 , The Japanese Biochemical Society

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