Rchr
J-GLOBAL ID:200901036746211905
Update date: Oct. 02, 2024
Oikawa Shinji
オイカワ シンジ | Oikawa Shinji
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
http://www.medic.mie-u.ac.jp/eiseigaku/
Research field (3):
Hygiene and public health (laboratory)
, Environmental effects of radiation
, Food sciences
Research keywords (5):
酸化ストレス
, 神経変性疾患
, 発がん機構
, aging
, carcinogenesis
Research theme for competitive and other funds (50):
- 2023 - 2027 若年性アルツハイマー病の原因解明と早期血液バイオマーカーの探索
- 2022 - 2025 Mechanism of action of cancer chemopreventive agents and its application to neurodegenerative diseases: Focus on inflammation
- 2019 - 2024 Cooking oil-derived hydroxynonenal and lifestyle-related diseases
- 2019 - 2023 Mechanism of epigenetic aberration in inflammation-related carcinogenesis: molecular epidemiology by a comparison of risk factors between Japan and China
- 2019 - 2023 認知症における血中エクソソーム内包酸化損傷タンパク質の変動解析とリスク診断
- 2019 - 2022 A strategic research to establish blood biomarker for cerebral amyloid angiopathy and disease modifying therapy in dementia.
- 2019 - 2022 Roles of DAMP and autophagy in inflammation-related carcinogenesis and its application to cancer prevention
- 2018 - 2021 A possible mechanism of Alzheimer's disease caused by lipid peroxidation
- 2018 - 2020 過酸化脂質によるアルツハイマー病発症機構の解明
- 2016 - 2019 Carcinogenic mechanisms of stem cells in inflammation-related cancer and its prevention
- 2016 - 2019 Establishment of early diagnostic markers for nasopharyngeal carcinoma and experimental verification through fieldwork in southern China
- 2015 - 2019 Development of a PET imaging agent and disease biomarker for Alzheimer's disease.
- 2015 - 2018 The compensatory micro circulation regulation mechanism against cerebral perfusion pressure decrease
- 2014 - 2017 Proteomic profiling of exosomal proteins for the early diagnosis of Alzheimer's disease and prevention of Alzheimer's disease
- 2015 - 2017 アルツハイマー病における新規PETイメージング試薬の開発とバイオマーカーの探索
- 2013 - 2016 Epigenetic alteration in inflammation-related carcinogenesis and its application to cancer prevention and therapy
- 2013 - 2016 Development of screening methods for early detection of nasopharyngeal carcinoma in southern China
- 2014 - 2016 エキソソームを用いたアルツハイマー病の早期診断法の開発と予防法の確立
- 2012 - 2015 A study on the pathogenic mechanism of amyotrophic lateral sclerosis (ALS) and search for efficient biomarkers using proteomic/metabolomic analysis
- 2011 - 2014 Development of risk assessment methods for parkinson's disease using carbonylated protein, a protein oxidation product, as a predictive indicator
- 2012 - 2014 プロテオーム・メタボローム解析を用いたALS発症機構の解明とバイオマーカーの探索
- 2011 - 2013 Molecular mechanisms for the pathogenesis of cancer cachexia that is observed in a conditionally K-raG12V-expressed tumor model animal
- 2011 - 2013 プロテオミクスによる酸化損傷蛋白質を指標としたパーキンソン病リスク評価法の開発
- 2010 - 2012 Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention
- 2010 - 2012 血液脳関門破綻と血管内皮障害とに共通する接着因子の作用メカニズムの解明
- 2010 - 2012 Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers
- 2009 - 2011 Cancer prevention study on the relationship of cancer stem cells biomarker and 8-nitroguanine in cancer tissues
- 2009 - 2011 Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.
- 2008 - 2010 パーキンソン病における酸化ストレス誘導神経細胞死の新規解明と予防法の確立
- 2007 - 2009 Molecular epidemiology study on carcinogenic mechanism of Epstein-Barr-associated nasopharyngeal carcinoma and modification by environmental factors in southern China
- 2007 - 2009 Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment
- 2006 - 2008 A study of aging induced by oxydative stress
- 2006 - 2008 Molecular epidemiological study for bladder carcinogenesis induced by parasite in Egypt
- 2006 - 2008 Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation
- 2006 - 2007 新規光増感剤ポルフィリン誘導体によるDNA損傷機構の解明と光線力学療法への応用
- 2005 - 2006 老化を促進する酸化損傷タンパク質の機能プロテオミクス解析と病的老化予防法の開発
- 2003 - 2005 Molecular epidemiological study on the pathogenesis of cholangiocarcinoma caused by infection with liver flukes in Thailand
- 2003 - 2005 The mechanism for the formation of hotspots in relation to evaluation of carcinogenic risks of environmental chemicals
- 2004 - 2004 酸化ストレスによる老化促進機構の解明と病的老化の予防
- 2003 - 2004 A study of carcinogenesis-mechanism induced by environmental chemical substance
- 2002 - 2003 Analysis of DNA damage by environmental and dietary factors
- 2001 - 2003 Development of evaluation system for cancer chemopreventive agents based on DNA damage inhibition and gene expression
- 2002 - 2002 新規アンプリファイヤーによる抗がん剤の細胞死誘導増強と協奏的DNA認識機構の解明
- 2000 - 2002 Analysis of sequence-specific DNA damage by oxidative stress and prevention of cancer and aging
- 2000 - 2001 Analysis of the human DNA damage by dietary factors via reactive oxygen species and cancer prevention
- 1999 - 2001 Evaluation of toxicity of environmental chemicals on the basis of their estrogenic activity and DNA-damaging ability and regional risk assessment
- 1999 - 2000 生活環境化学物質と生体内物質との相互作用によるヒト遺伝子損傷と感受性の解析
- 1998 - 2000 The method of safety evaluation of chemopreventive agents based on the ability of damaging human genes
- 1998 - 1998 太陽紫外線特にUVAによる遺伝子損傷機構の解析
- 1995 - 1996 Industrial chemicals induced neural apoptosis with its relation to active oxygen species
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Papers (243):
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Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata, Shinji Oikawa. Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage. Genes and Environment. 2024. 46. 1
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Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murata. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. 2024. 14. 1. 7427-7427
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Kaoru Midorikawa, Kokoro Kobayashi, Shinya Kato, Shosuke Kawanishi, Hatasu Kobayashi, Shinji Oikawa, Mariko Murata. Oxidative DNA damage: induction by fructose, in vitro, and its enhancement by hydrogen peroxide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2023. 503719-503719
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Yuichiro Hirao, Hatasu Kobayashi, Yurie Mori, Shinya Kato, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa. Myricetin causes site-specific DNA damage via reactive oxygen species generation by redox interactions with copper ions. Mutation research. Genetic toxicology and environmental mutagenesis. 2023. 891. 503694-503694
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Guofei Feng, Yasushi Arima, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Weilin Zhao, Zhe Zhang, Kazuhiko Takeuchi, Mariko Murata. Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway. Cancer Cell International. 2023. 23. 1
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MISC (154):
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馮 国飛, 有馬 寧, 翠川 薫, 及川 伸二, 小林 果, Zhao Weilin, Zhang Zhe, 竹内 万彦, 村田 真理子. トランスフェリン受容体のノックダウンは上咽頭癌の細胞増殖および浸潤を抑制する(Knockdown of transferrin receptor suppresses cell proliferation and invasion of nasopharyngeal carcinoma). 日本癌学会総会記事. 2022. 81回. P-1290
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FENG Guofei, FENG Guofei, HE Feng, HE Feng, 有馬寧, 翠川薫, 及川伸二, 小林果, 竹内万彦, 村田真理子. GDF10はTGF-β/Smad/NF-κB経路を介して上咽頭癌の進展を抑制する. 日本衛生学雑誌(Web). 2022. 77. Supplement
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岡野元彦, 岡野元彦, 何峰, 有馬寧, 小林果, 及川伸二, 西村廣明, 俵功, 村田真理子. 上咽頭癌細胞のオートファジー及びアポトーシス関連分子発現に対するタウリンの影響. 日本衛生学雑誌(Web). 2022. 77. Supplement
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平工雄介, AHMED Sharif, 小林果, AFROZ Tahmina, 馬寧, 及川伸二, 川西正祐, 村田真理子. インジウム化合物による肺上皮細胞におけるDNA損傷. 産業衛生学雑誌. 2022. 64. 1
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馮国飛, 馮国飛, 徐軼菲, 徐軼菲, 有馬寧, 翠川薫, 及川伸二, 竹内万彦, 村田真理子. 上咽頭癌におけるマクロファージ分化とEpstein-Barrウィルス,ヒトパピローマウィルス,MIFとの関係. 日本癌学会学術総会抄録集(Web). 2021. 80th
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Books (4):
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抗酸化物質のプロオキシタント作用とDNA損傷性を指標にした安全性評価
食と生活病 昭和堂 2003
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発がん性(共著)
中毒学(荒木俊一 編)/朝倉書店 2002
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Role of Metal in Oxidative DNA Damage by Non-mutagenic Carcinogen
Genetic Response to Metals 1995
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Oxygen Radical Formation and Site-specific DNA Damage by Metal and Carcinogen
Frontiers of reactive oxygen species in biology and medicine 1994
Works (2):
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Generation of Hydroxyl Radical, Oxidative DNA Lesion and Mutagenesis in E. coli
1999 -
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Damage Induced by Nitroxyl Arion in the Presence of Hydrogen Peroxide
1999 -
Education (3):
- - 1993 Hokkaido University
- - 1993 Hokkaido University Graduate School, Division of Environmental Science
- - 1985 Hokkaido University Faculty of Fisheries
Professional career (1):
- (BLANK) (Hokkaido University)
Work history (7):
- 1997/03 - 現在 Mie University Graduate School of Medicine
- 1995 - 1997 Jikei University
- 1995 - 1997 The Jikei University School of Medicine
- 1994 - 1995 Kyoto University Faculty of Medicine
- 1994 - 1995 Kyoto University, Faculty of Medicine
- 1992 - 1994 日本学術振興会 特別研究員
- 1992 - 1994 Fellowships of the Japan Society for the Promotion of Science for Japanese Junior Scientists.
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Committee career (4):
- - 現在 日本環境変異原学会 評議員
- - 現在 Mutation Research - Genetic Toxicology and Environmental Mutagenesis Editorial Board
- - 現在 日本フリーラジカル学会 評議員
- - 現在 衛生学会 評議員
Awards (5):
- 2024/09 - 三重大学 令和6年度三重大学知的財産最優秀出願賞 対象が脳アミロイド血管症を有するかを判定するための方法、組成物およびキット
- 2015 - 学術振興会 「科研費」審査委員表彰
- 2006 - 日本環境変異原学会研究奨励賞
- 2004 - 日本衛生学会奨励賞
- 2001 - 日本光医学・光生物学会奨励賞
Association Membership(s) (10):
日本分子生物学会
, 日本フリーラジカル学会
, 日本基礎老化学会
, 環境ホルモン学会
, 日本光医学・光生物学会
, 環境変異原学会
, 環境科学会
, 衛生学会
, 癌学会
, 生化学会
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