Yoshikawa Kiyotsugu

ヨシカワキヨツグ | Yoshikawa Kiyotsugu

Affiliation and department：
Job title： Professor

Research field (1)： Tumor diagnostics and therapeutics

Research keywords (2)：分子生物学 , Molecular Biology

Research theme for competitive and other funds (9)：

2022 - 2025 上皮化誘導・DNA修復抑制性短鎖RNAと細胞運命制御による難治性癌治療法の創出
2018 - 2022 Development of therapeutic strategy targeting epithelial-mesenchymal transition and cell-fate determination factor for malignancy
2015 - 2017 Establishment of luminal induction therapy of triple-negative breast cancer stem cells
2012 - 2014 Application of sensitive EMT/MET reporter to identification of target genes for breast cancer stem cells.
2003 - 2004 AIDによる免疫グロブリン遺伝子体細胞突然変異導入のメカニズムの解明

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Papers (38)：

Yosuke Mitani, Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Ayaka Mizumoto, Yoshihiro Yamamoto, Tomoki Saito, Shigeki Kataoka, Junichi Matsubara, et al. HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function. Scientific reports. 2022. 12. 1. 9213-9213
Shi G, Yoshida Y, Yuki K, Nishimura T, Kawata Y, Kawashima M, Iwaisako K, Yoshikawa K, Kurebayashi J, Toi M, et al. Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity. Oncotarget. 2016. 7. 50. 82158-82169
Tingfang Yi, Bo Zhai, Yonghao Yu, Yoshikawa Kiyotsugu, Thomas Raschle, Manuel Etzkorn, Hee-Chan Seo, Michal Nagiec, Rafael E. Luna, Ellis L. Reinherz, et al. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111. 21. E2182-E2190
Junji Itou, Yoshiaki Matsumoto, Kiyotsugu Yoshikawa, Masakazu Toi. Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. FEBS LETTERS. 2013. 587. 18. 3115-3121
Il-mi Okazaki, Katsuya Okawa, Maki Kobayashi, Kiyotsugu Yoshikawa, Shimpei Kawamoto, Hitoshi Nagaoka, Reiko Shinkura, Yoko Kitawaki, Hisaaki Taniguchi, Tohru Natsume, et al. Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011. 108. 19. 7920-7925

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MISC (12)：

吉川清次, 荒川芳輝, 戸口田淳也, 戸井雅和. 間葉転換解除による難治性がん治療法の開発. 日本癌学会総会記事. 2016. 75回. E-1045
吉川清次, 荒川芳輝, 戸口田淳也, 戸井雅和. 間葉転換解除による難治性がん治療法の開発. 日本癌学会総会記事. 2016. 75回. E-1045
吉川清次, 酒井浩旭, 嶋崎雅広, 岡田宣宏, 松本純明, 戸井雅和, 戸井雅和. トリプルネガティブ乳癌とグリオブラストーマにおけるMETによる分化療法の検討. 日本癌治療学会学術集会(Web). 2015. 53rd
Tingfang Yi, Bo Zhai, Yonghao Yu, Yoshikawa Kiyotsugu, Thomas Raschle, Manuel Etzkorn, Hee-Chan Seo, Michal Nagiec, Rafael E. Luna, Ellis L. Reinherz, et al. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells (vol 111, pg E2182, 2014). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111. 30. 11223-11223
Kiyotsugu Yoshikawa, Yoshiaki Matsumoto, Junji Ito, Yoshie Shiojiri, Ellis Reinherz, Masakazu Toi. Application of sensitive EMT reporter to identification of breast cancer stem cell-related genes. CANCER RESEARCH. 2013. 73

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Books (3)：

乳癌レビュー(乳癌とDNA修復)
メディカルレビュー 2012
乳癌レビュー(乳癌幹細胞)
メディカルレビュー 2012
乳癌幹細胞特性とepithelial-mesenchymal transition
最新医学社 2010

Lectures and oral presentations (2)：

Application of sensitive epithelial-mesenchymal transition (EMT) reporter to identification of mammary stem cell-related genes
(Oncology and Translational Research the 8th annual conference 2012)
乳癌幹細胞についての最近の知見と創薬標的同定の試み
(第42回滋賀県立成人病センター研究所セミナー 2012)

Education (4)：

- 1999 Kyoto University
- 1999 Kyoto University Graduate School, Division of Medicine
- 1989 Kyoto University Faculty of Medicine Department of Medical Science
- 1989 Kyoto University Faculty of Medicine

Professional career (1)：

Doctor of Medicine (Kyoto University)

Association Membership(s) (5)：

日本死の臨床研究会 , 日本乳癌学会 , 日本免疫学会 , 分子生物学会 , 日本癌学会

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