Rchr

J-GLOBAL ID：200901037323556511 Update date: Jul. 28, 2024

Toyoshima Chikashi

トヨシマチカシ | Toyoshima Chikashi

Affiliation and department：
Job title： Professor,Professor
Homepage URL (1)： http://www.iam.u-tokyo.ac.jp/StrBiol/

Research field (1)： Biophysics

Research keywords (6)：構造解析 , 結晶化 , 膜蛋白質 , ion pump , membrane proteins , structural biology

Research theme for competitive and other funds (34)：

2023 - 2026 イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展
2023 - 2025 Development of artificial reaction intermediates by introduction of steric hindrance
2022 - 2025 多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
2020 - 2023 異常凝集体に対する体外診断法開発によるアルツハイマー病の早期診断と病態解明
2020 - 2022 Developement of technology for visualising lipid bilayers in crystals of membrane proteins

2019 - 2022 Structural biology of active transport and its regulation by P-type ATPases

2012 - 2015 Visualization of Coulomb potential by electron crystallography

2002 - 2006 P型イオンポンプによる能動輪送機構の構造的解明

1998 - 2003 Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation

1999 - 2002 Ca-ATPaseの電子線・X線結晶解析

1999 - 2001 Crystallographics study of active ion transport

1998 - 1999 Development of electron diffraction methods for protein crystallography

1998 - 1999 Structural elucidation of active ion transport

1997 - 1998 Crystallographic study of calcium ion pump of sarcoplasmic reticulum

1996 - 1998 Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels

1996 - 1997 Structural Basis of Active Transport by Ion Pumps

1995 - 1997 チャネルとトランスポータの構造・機能相関

1996 - 1996 イオンチャンネル機能を実現する超分子構造の化学的,物理学的解析

1995 - 1996 Elucidation of the organization mechanism of dynamic higher-ordered structures in biological cells

1994 - 1996 Conformation of the Muscarinic Acetylcholine Receptor

1995 - 1995 イオンチャンネル機能を実現する超分子構造の化学的、物理学的解析

1994 - 1995 New Generation of Protein Crystallography

1994 - 1995 Gating mechanism of the acetylcholine receptor ion channel

1993 - 1995 PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS

1994 - 1994 NMDAレセプターの大量生産とその三次元構造解析

1994 - 1994 化学的,物理学的手法によるイオンチャンネル超分子構造の解析

1993 - 1994 Development of technologise for three-dimensional structural analysis of protein crystals using electron microscope

1993 - 1993 低温電子顕微鏡法による呼吸鎖酵素複合体二次元結晶の三次元構造解析

1992 - 1993 Three-dimensional strutural study of the sarcoplasmic reticulum clcium ATPase under various physiological conditions.

1990 - 1993 Folding and crystallization conditions of menbrane protein supercomplexes

1992 - 1992 低温電子顕微鏡による呼吸鎖酵素複合合体二次元結晶の三次元構造解析

1991 - 1992 Time-resolved 3-dimensional Structural Study of Biological Reactions by Flash Photolysis and Frozen-hydrated Electron Microscopy

1991 - 1991 氷包埋低温電子顕微鏡によるカルシウムATPaseの三次元構造解析

1990 - 1990 膜蛋白質3次元微結晶の電子線構造解析

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Papers (64)：

Ryuta Kanai, Bente Vilsen, Flemming Cornelius, Chikashi Toyoshima. Crystal structures of Na+ ,K+ -ATPase reveal the mechanism that converts the K+ -bound form to Na+ -bound form and opens and closes the cytoplasmic gate. FEBS letters. 2023
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima. Cryo-electron microscopy of Na+ ,K+ -ATPase reveals how the extracellular gate locks in the E2·2K+ state. FEBS letters. 2022
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima. Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 15. e2123226119
Ryuta Kanai, Flemming Cornelius, Haruo Ogawa, Kanna Motoyama, Bente Vilsen, Chikashi Toyoshima. Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 1
Yoshiki Kabashima, Haruo Ogawa, Rie Nakajima, Chikashi Toyoshima. What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117. 31. 18448-18458

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MISC (122)：

TOYOSHIMA Chikashi. Crystal structure analysis of P-type ATPase. 2018. 23. 4. 334-342
豊島近, 乗松良行. X線コントラスト変調法によって明らかになった膜蛋白質と燐脂質の相互作用のダイナミクス. 放射光. 2018. 31. 3. 212-218
乗松良行, 豊島近. はじめて解像された膜タンパク質とリン脂質の相互作用のダイナミクス. 実験医学. 2017. 35. 6. 2741-2744
H. Ogawa, C. Toyoshima. Large production of mammalian membrane proteins toward determination of high-resolution structure. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S169-S169
Haruo Ogawa, Chikashi Toyoshima. Large Scale Production of Mammalian Membrane Proteins Toward Determination of High-Resolution Structure. BIOPHYSICAL JOURNAL. 2017. 112. 3. 188A-188A

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Books (4)：

Three-dimensional structural study of Ca2+-ATPase from sarcoplasmic reticulum. Na/K-ATPase and Related ATPases, eds. K. Taniguchi and S. Kaya
Elsevier 2000
The Ca2+ pump of sarco-and endoplasmic reticulum membranes. In ''Calcium Homeostasis(Topics in Biological Inorganic Chemistry Vol. 3) '' eds. E. Carafoli and J. Krebs, Springer-Verlag
Berlin 2000
「構造生物学とその解析法」日本生物物理学会/シリーズ・ニューバイオフィジックス刊行委員会編
共立出版 1997
「レセプター-基礎と臨床」
朝倉書店 p288-296

Lectures and oral presentations (49)：

Structural Biology of Ion Pumps : From lipid bilayer to proton
(2019)
P 型 ATPase によるイオン輸送とその制御機構
(日本薬学会第139年会 2019)
Role of phospholipids in ion pumping
(5th ShanghaiTech-SIAIS Bioforum 2018)
The current situation of crystal structure analysis of Ca pump
(2018)
Structural Biology of the Calcium Pump
(WCP2018 - 18th World Congress of Basic and Clinical Pharmacology 2018)

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Education (2)：

- 1983 The University of Tokyo
- 1978 The University of Tokyo Faculty of Science Department of Physics

Professional career (1)：

理学博士 (東京大学)

Work history (9)：

2020/04 - 現在東京大学定量生命科学研究所特任教授、東京大学特別教授室特別教授
2018/04 - 2020/03 改組により東京大学定量生命科学研究所教授
1994 - The University of Tokyo Institute of Molecular and Cellular Biosciences
1990 - Tokyo Institute of Technology School of Science
1989 - 理化学研究所・国際フロンティア研究員

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Awards (10)：

2018/06 - The Japan Academy Imperial Prize and Japan Academy Prize Elucidation of the Molecular Mechanism of the ATP-driven Ion-transport across the Membranes
2016 - 武田科学振興財団 2016年度武田医学賞
2016 - 上原記念生命科学財団平成27年度上原賞
2016 - スウェーデン王立科学アカデミー Gregori Aminoff Prize
2015 - 紫綬褒章

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Association Membership(s) (1)：

日本生物物理学会

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