Rchr

J-GLOBAL ID：200901037330991126 Update date: Sep. 29, 2024

Ishihara Kazuyuki

イシハラカズユキ | Ishihara Kazuyuki

Affiliation and department：
Job title： Professor

Research field (2)： Oral medicine , Bacteriology

Research keywords (5)： Microbiology , Oral bacteria , Microbiome , Periodontitis , Treponema

Research theme for competitive and other funds (44)：

2023 - 2026 口腔細菌Capnocytophaga属がもたらす口腔扁平上皮癌悪性化機構の解明
2022 - 2025 Augumentation of virulence by interaction between periodontopathic bacteia
2020 - 2023 Treponema denticolaの細胞侵入機構と免疫回避機構の解明
2019 - 2022 Analysis of microbiome organized on denture base of older adults
2019 - 2022 カンジダ・アルビカンス細胞表層蛋白を標的としたカンジダ症治療薬開発への新たな試み

2018 - 2021 Investigation of epigenetic change in the epithelial cells induced by periodontopathic bacteria

2018 - 2021 口腔細菌カプノサイトファガをトリガー細菌とする歯周病発症機構の解明

2016 - 2020 Investigation of development and progression mechanism of oral candidiasis

2016 - 2019 Response of epithelial cells infected by Treponema denticola

2015 - 2018 Microbiome analysis of apical periodontitis and cellulitis in oral cavity

2014 - 2017 Development of new periodontal disease prevention method using ECF sigma factors of periodontal pathogenic bacteria

2013 - 2016 Investigation of the molecular mechanisms involved in host cell invasion by periodontal pathogens under the exposure by cigarette smoke.

2012 - 2015 Investigation of virulence of microorganisms in polymicrobial infection

2010 - 2012 A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation

2009 - 2011 Investigation of consortia formation by periodontopathic bacteria

2009 - 2011 Association between biofilm formation and amiloyd-like fiber in Aggregatibacter actinomycetecomitans

2007 - 2010 Rejuvenation with oral aging analysis

2007 - 2008 Proteomics analysis of bacterial interaction in biofilm

2006 - 2008 Development of immediate implant system with biofunctionalization using drug delivery system

2005 - 2007 Biofilm eliminative strategy for Periodontal therapy

2005 - 2007 The Effect of antimicrobial agent to artificial biofilm formed by periodontopathic bacteria

2004 - 2006 Role of coaggregation among periodontopathic bacteria in formation of periodontopathic biofilm

2003 - 2005 Disturbance of the immune responses by periodontopathic bacterial virulence factors and host defense activity of salivary proteins

2002 - 2005 Can periodontopathic bacteria induce the cytokines production that cause atherosclerosis in ApoE knockout mice ?

2001 - 2003 Molecular biological research for Periodontal pathogenic surface antigens of Campylobacter rectus.

2000 - 2003 Analysis of Hellcobacter pylori infection route from oral biological view point.

2000 - 2002 The analysis of the immune response to the virulence factors of the periodontopathic bacteria

1999 - 2002 Analysis for pathogenicity of periodontal disease-associated anaerobesin silent aspirated pneumoniae

1999 - 2001 Molecular and immunological analysis of periodontopathic bacterial attachment factors

1999 - 2000 歯周病原性グラム陰性菌による呼吸器感染症起因性に関する研究

1999 - 2000 歯周病原性細菌の免疫調節物質の分子生物学的解析

1998 - 1999 Helicobacter pylori Infection and its Immune Response in Patients with Intraoral Tumors

1997 - 1998 Molecular analysis of pathogen in periodontopathic bacteria

1996 - 1998 Analysis of the virulence factors from periodontopathic bacteria

1996 - 1997 Molecular Analysis of Infectious Mechanisin of A.actinomycelemcomitans

1996 - 1997 歯周病原菌感染予防DNAワクチンの検討

1994 - 1995 Study of the virulence factors from periodontopathic bacteria

1994 - 1995 Molecular analysis of protease from Treopnema denticola

1990 - 1992 歯周病原菌内毒素の細胞および実験的ペリクルへの付着に関する研究

1991 - 1991 口腔トレポネーマの病原性因子の遺伝学的解析

1990 - 1991 The heterogeneity of various Porphyromonas gingivalis strains to adherence and invasive.

1989 - 1991 Molecular biological Analysis of Periodontopathic Bacteria

1990 - 1990 口腔トレポネーマの病原因子の遺伝学的解析

1988 - 1989 Attachment and invasion of periodontopathic bacteria tosubgingival site

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Papers (250)：

Yumi Numata, Yuichiro Kikuchi, Toru Sato, Kazuko Okamoto-Shibayama, Yutaro Ando, Yuri Miyai-Murai, Eitoyo Kokubu, Kazuyuki Ishihara. Novel transcriptional regulator OxtR1 regulates potential ferrodoxin in response to oxygen stress in Treponema denticola. Anaerobe. 2024
Hisako Ishizuka, Kazuna Ishihara, Hideo Yonezawa, Kazuyuki Ishihara, Takashi Muramatsu. Inhibitory effect of bovine milk osteopontin on the initial attachment of Streptococcus mutans. JDS Communications. 2024
Hideo Yonezawa, Eitoyo Kokubu, Yuichiro Kikuchi, Kazuyuki Ishihara. Complete genome sequence of Fusobacterium vincentii strain TDC100 isolated from an apical periodontitis lesion. Microbiology Resource Announcements. 2024
Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, et al. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. International journal of oral science. 2024. 16. 1. 18-18
Takahisa Shirai, Yutaroh Satoh, Kazuyuki Ishihara. Antibacterial activity of mulberry extracts and purified fractions against oral pathogenic bacteria. Journal of Oral Biosciences. 2024

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MISC (168)：

明由理亜, 秋山友理恵, 三邉正樹, 石原和幸, 野村武史, 河野通良. 掌蹠膿疱症患者と関節リウマチ患者の唾液マイクロバイオームの比較. 日本口腔科学会学術集会プログラム・抄録集. 2023. 77th
久永理央, 久永理央, 北村友里恵, 山下慶子, 齋藤淳, 齋藤淳, 石原和幸, 石原和幸. Treponema denticolaの病原性発現における転写調節因子様遺伝子の役割の解明. 歯科学報. 2023. 123. 2
吉川幸輝, 国分栄仁, 国分栄仁, 北村友里恵, 久永理央, 久永理央, 山下慶子, 齋藤淳, 齋藤淳, 石原和幸. Porphyromonas gingivalis Hgp44の付着ドメインがTreponema denticolaとのバイオフィルム形成に与える影響. 歯科学報. 2022. 122. 2
久永理央, 久永理央, 北村友里恵, 山下慶子, 齋藤淳, 齋藤淳, 石原和幸, 石原和幸. Treponema denticolaの病原性発現におけるtranscriptional regulator様遺伝子の役割の解明. 歯科学報. 2022. 122. 2
久永理央, 北村友里恵, 山下慶子, 石原和幸, 石原和幸, 齋藤淳, 齋藤淳. Treponema denticolaの病原性発現における新規転写調節因子の役割の解明. 日本歯周病学会会誌(Web). 2022. 64

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Books (16)：

細菌学的アプローチによる歯内療法の臨床バイオフィルム感染症として捉え解決に導く
医歯薬出版株式会社 2023 ISBN:9784263446706
掌蹠膿疱症性骨関節炎診療の手引き2022
文光堂 2022 ISBN:9784830634796
細菌検査を用いた歯周治療のコンセプト-リスクコントロールとしての抗菌療法
医学情報社 2021 ISBN:4900807915
イラストでわかる歯科医学の基礎
永末書店 2021 ISBN:9784816013935
口腔微生物学 : 感染と免疫
学建書院 2021 ISBN:9784762466540

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Lectures and oral presentations (140)：

The role of responses against environmental stress on the pathogenicity of Treponema denticola
(2024)
Treponema denticolaの病原性発現および増殖におけるHxlR family transcriptional regulator の役割の検討
(第317回東京歯科大学学会 2024)
The effect of responses against environmental stress on the pathogenicity of Treponema denticola
(Gordon Research Conference, Biology of Spirochete 2024)
牛乳由来オステオポンチンのStreptococcus mutansに対する付着抑制効果の検討
(第316回東京歯科大学学会総会 2023)
石原和幸
(2023)

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Education (2)：

1985 - 1989 Tokyo Dental College Graduate School, Division of Dental Research Microbiology
1979 - 1985 Tokyo Dental College

Professional career (1)：

Ph.D., D.D.S. (Graduate School, Division of Dental Research, Tokyo Dental College )

Work history (8)：

2008/04 - 現在 Tokyo Dental College Department of Microbiology Professor
2007/04 - 2008/03 Tokyo Dental College Dpartment of Microbiology Associate Professor
2002/04 - 2007/03 Tokyo Dental College Department of Microbiology Associate Professor
1994/04 - 2002/04 Tokyo Dental College Department of Microbiology Assistant Professor
1994/01 - 1994/03 Tokyo Dentral College Department of Microbiology Assistant

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Committee career (3)：

2015/04 - 現在日本歯周病学会理事
2002/04 - 歯科基礎医学会代議員
1998 - 日本細菌学会評議員

Awards (5)：

2007 - Japanese Society of Periodontology JSP Distinguished Scientist Award
2005 - The Waxman Foundation of Japan Award from The Waxman Foundation of Japan
2004 - Tsuchiya Foundation Award from Tsuchiya Foundation
2000 - Japanese Society for Bacteriology Kuroya Award of Japanese Association for Microbiolgy
1997 - Japanese Association for Oral Biology 9th Rising Members Award of Japanese Association for Oral Biology

Association Membership(s) (5)：

Japanese Society of Periodontology , International Association for Dental Research , The Tokyo Dental College Sciety , Japanese Association for Oral Biology , Japanese Society for Bacteriology

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