Date Hiroshi

2019 - 2022 Development of innovative organ preservation solutions using functional ultrafine bubbles

2019 - 2022 Reduction of donor mononuclear phagocytes during ex vivo lung perfusion attenuates ischemia-reperfusion injury in a rat lung transplantation model

2019 - 2021 Innovative therapy for chronic respiratory failure using organoid technique

2018 - 2021 Development of selective immunosuppressive therapy preserving natural immunity for treating chronic rejection after lung transplantation

2018 - 2020 The elucidation of key signaling pathways and the establishment of treatment strategies for mutant p53-induced epithelio-mesenchymal transition in lung cancer

2017 - 2020 Establishment of noninvasive nuclear monitoring for chronic rejection after lung transplantation and development of early therapy

2017 - 2020 Large animal experimental study on lung repair by hydrogen diffusion for lung transplantation from donation after cardiac death

2017 - 2020 Development of a new material to prevent postoperative adhesions following pulmonary resection

2016 - 2019 Significance of sarcopenia in chronic respiratory diseases

2019 - 2019 肺移植後遠隔期における身体活動性とその他臨床指標との関連

2016 - 2018 Comprehensive analyses of transcriptome and DNA copy number variations in thymic cancer

2015 - 2018 Early diagnosis and novel treatment with low-dose IL-2 of humoral rejection in lung transplantation.

2016 - 2017 チロシンキナーゼ阻害剤を用いた新たな臓器保存・虚血再灌流肺障害治療戦略

2015 - 2017 Multilateral investigation on various antibodies aiming at realization of ABO incompatible and/or crossmatch positive lung transplantation

2014 - 2017 Lung repair by inhalation therapy during ex-vivo lung perfusion for lung transplantation from donation after circulatory death

2014 - 2017 Transcriptome analysis of pulmonary arterioles in interstitial pneumonia with pulmonary hypertension

2014 - 2016 Comprehensive kinome analysis of metastatic activity in lung cancer cells

2013 - 2016 The analysis of predictive markers for the efficacy of cisplatin and vinorelbine regimens as postoperative adjuvant chemotherapy of lung cancer

2013 - 2015 Research on antibody-mediated rejection aiming for lung transplantation with positive crossmatched and ABO-incompatible donors

2012 - 2015 Balance between memory T cell and regulatory T cell in lung transplant recipients

2011 - 2014 Experimental study to repair non-heart beating donor lung using ex-vivo lung perfusion for clinical application

2011 - 2014 Attenuation of hyperacute dysfunction and coagulopathy in GalT-KO pulmonary xenotransplantation

2011 - 2013 Pre-clinical study on pulmonary perfusion preservation using modified ET-Kyoto solutions

2011 - 2013 Non-invasive assessment for acute rejection in lung transplantation.

2011 - 2013 Gene therapy using FGFR-inhibiting vector against lung squamous cell carcinoma

2010 - 2012 Detection of new fusion partner genes with ALK gene

2011 - 2011 ドナー肺の長時間低温保存における至適保存方法検討

2009 - 2011 臨床肺移植の予後改善を目指した移植免疫学的研究の新たな展開

2009 - 2011 Preclinical study for tolerance induction in lung transplantation

2008 - 2010 A large animal experimental study to establish a clinical applicable method for lung transplantation utilizing non-heart beating donors

2008 - 2010 Development of a method for simultaneous multiple thoracic and abdominal organ procurement using ET-Kyoto solution

2008 - 2010 Basic research for evaluating the donor lung mechanical properties using FOT (Forced Oscillation Technique)

2008 - 2010 Pre-clinical study on the protective effect of drug inhalation on the lung graft from donor after cardiac death

2008 - 2009 新規ナノキャリアーを利用した癌の標的治療

2007 - 2009 The serum level of de novo donor specific antibody can predict acute rejection in lung transplantation.

2006 - 2007 Experimental Study on Microthrombi Formation for Lung Transplantation from Non-Heart-Beating Donor

2006 - 2007 Modified low-flow ultrafiltration ameliorates hemodynamics and early graft function and reduces blood loss in living-donor lobar lung transplantation

2005 - 2007 Investigation of vascular resistance reducing therapy for primary pulmonary hypertension: replacement of RBC with nano-order liposomal hemoglobin

2003 - 2006 An experimental study about development of the ventilator for total liquid ventilation and its optimal respiratory setting.

2004 - 2005 RESEARCH ON PORTABLE ARTIFICIAL BOOSTER LUNG

2004 - 2005 Experimental Study to Develop a New Procedure for Living-Donor Lobar Lung Transplantation

2004 - 2005 Serum tumor necrosis factor α, Interleukin-6, and polymorphonuculear elastase levels during lung transplantation with cardiopulmonary bypass

2002 - 2003 Research on Mobile Artificial Booster Lung

2002 - 2003 Experimental Study on Pulmonary Function and Lung Growth after Living-Donor Lobar Lung Transplantation

2002 - 2003 Effect of Nitric Oxide and Cytokines for Reperfusion Lung Injury in Living-donor Lung Transplantation

1999 - 2002 An experimental study about anti-local inflammation effects of liquid ventilation.

2000 - 2001 A study about total pulmonary replacement with artificial intra-thoracic implantable lung.

2000 - 2001 Expeimental Study on Pulmonary Function and Lung Growth after Living-Donor Lobar Lung Transplantation

2000 - 2001 The relationship between anti-donor antibodies and acute rejection in lung transplantation

1996 - 1998 Measurement of Lung Volume by Lung Ventilation Scanning using SPECT and Prediction of Postoperarive pulmonary function

1995 - 1996 A Experimental Study for Pulmonary Transplantation from Non-heart-beating Donor.

肺癌

肺気腫

肺移植

Lung Cancer

Emphysema

Lung Transplantation