Research field (4)：
Food sciences
, Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (6)：
薬物デザイン
, 生物薬剤学
, 薬物送達システム
, Drug Design
, Biopharmaceutics
, Drug Delivery System
Research theme for competitive and other funds (42)：
2023 - 2025 Development of covalent protein drug with unnatural amino acids
2016 - 2019 Preclinical and clinical study of influenza microneedle vaccine and analysis of immunity induction mechanism
2015 - 2017 Development of novel transdermal immunotherapy aimed at curing food allergies
2013 - 2016 Analysis of physicochemical characteristics of microneedle patch, and development of novel therapeutic approach for seborrheic keratosis treatment
2013 - 2015 Exploration of adjuvant for optimization of transcutaneous vaccine
2011 - 2012 Development of a novel transcutaneous vaccination device using a dissolving microneedle array.
2010 - 2012 Development of a tumor diagnosis system using novel immuno-PET/MRI probe
2008 - 2010 Construction of antibody-based molecular imaging techniques to analyze a development of tumor angiogenesis.
2005 - 2007 免疫担当細胞の体内動態制御に基づく癌治療の最適化
2005 - 2006 アポトーシス抵抗性を有する樹状細胞を用いた癌免疫療法の最適化
2004 - 2004 改変型アデノウイルスベクターを用いたin vivo胎盤毒性評価系の構築
2003 - 2004 Development of nanomedicine system based the control of intracellular pharmacokinetics.
2003 - 2004 高分子バイオコンジュゲート化アデノウイルスベクターの粒子設計とその評価
2001 - 2003 Development of intracellular controlled release system for optimization of gene therapy
2001 - 2003 Development of novel vaccine adjuvant for infectious disease
2001 - 2002 Development of Fiber-Mutant Adenovirus Vectors for targeting gene therapy
2001 - 2002 Enhancement of the specific activities of PEGylated proteins by a simple procedure using a reversible amino-protective reagent
1995 - 1996 Preparation of aniti-tumor tissue endothelium antibodies and its application of cancer-missle therapy
1995 - 1996 Development of fusogenic liposomes which can deliver any substances into the cells through membrane fusion
1995 - 1995 キメラマウス作成によるメンケス病の病因解析に関する研究
1994 - 1994 腫瘍誘導血管新生のin vivo評価法の開発とその応用
ワクチンのDDS
細胞性製剤の開発
遺伝子治療におけるDDS研究
Drug Delivery System for Vaccine
Development of Cytomedicine
Application of DDS for the gene therapy
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Papers (131)：
Kenji Ishimoto, Yuma Konishi, Shuichi Otani, Soya Maeda, Yukio Ago, Nobumasa Hino, Masayuki Suzuki, Shinsaku Nakagawa. Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy. Journal of natural medicines. 2023. 77. 3. 604-609
Kotaro Sakamoto, Wararat Kittikulsuth, Eijiro Miyako, Akumwami Steeve, Rika Ishimura, Shinsaku Nakagawa, Yukio Ago, Akira Nishiyama. The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody. PloS one. 2023. 18. 7. e0286651
Mineyuki Mizuguchi, Yusuke Nakagawa, Kishin Inui, Wakana Katayama, Yurika Sawai, Ayaka Shimane, Ryota Kitakami, Takuya Okada, Yuko Nabeshima, Takeshi Yokoyama, et al. Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. Journal of medicinal chemistry. 2022. 65. 24. 16218-16233
Kotaro Sakamoto, Bangzhong Lin, Kazuto Nunomura, Takeshi Izawa, Shinsaku Nakagawa. The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors. Scientific Reports. 2022. 12. 1. 8121-8121
石本憲司, 石本憲司, 中川晋作, 中川晋作. Preparation and evaluation of amorphous β-carotene for the development of functional foods. 日本薬学会年会要旨集(Web). 2021. 141年会. S38-5
谷川清香, 大川勝也, 北惠郁緒里, 長谷拓明, 神宮司健太郎, CHEN Lu, 山口拓海, 吾郷由紀夫, 中川晋作, 辻川和丈. Investigation on the mechanism of recognition disorder for mouse lacking Alkbh8. 日本薬学会年会要旨集(Web). 2021. 141年会. 29V05-pm19S
古庵大地, 今戸瑛二, 浅野智志, 浅野智志, CHEN Lu, 宮岡辰典, 山田めゐ, 石本憲司, 石本憲司, 中川晋作, et al. Neuron-specific VPAC2 receptor overexpression leads to cognitive impairment in mice. 日本薬学会年会要旨集(Web). 2021. 141年会. 27P02-118S
小西佑磨, 石本憲司, 石本憲司, 大植颯, 大谷修一, 大谷修一, 前田壮矢, 前田壮矢, 吾郷由希夫, 吾郷由希夫, et al. Basic study on the anti-allergic effect of the tea-derived material epigallocatechin gallate. 日本薬学会年会要旨集(Web). 2021. 141年会. 28P01-212S
