2017 - 2020 Transport mechanisms of fatty acids and drugs bound to glomerular filtered albumin in renal proximal tubule
2014 - 2017 Molecular mechanisms underlying HIF-1 activation by fatty acid-bearing albumin and renal protective effect by its regulation
2010 - 2014 Establishment of a new alveolar epithelial cell model by gene transfection and its application to the study on drug transport and toxicity in the lungs
2011 - 2013 Identification of primary molecule leading to aminoglycoside-induced nephrotoxicity and optimization of molecular-targeted approach for preventing aminoglycoside toxicity
2009 - 2010 Pharmacokinetics of IgG and FcRn expression under normal and disease conditions
2007 - 2009 Study on the transport of proteins in alveolar type I/II epithelial cells for the development of new pulmonary DDS systems
2007 - 2009 Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects
2007 - 2008 Pharmacokinetic properties of vitamin-binding proteins and these application to vector for drug delivery
2005 - 2006 Development of protein drug delivery system from the lung based on ligand recognition mechanisms of the receptors
2001 - 2002 Studies on the mechanisms underlying renal tubular deficiency due to the lack of the expression and function of CLCN5, a gene responsible for Dent's disease
1999 - 2001 Effect of endocrine disrupting chemicals on host defense mechanism (transpoter, enzymes)
1999 - 2000 Search for the new, endogenous compound with multidrug resistance modulating activity and its application to cancer chemotherapy
1998 - 1999 ホルモン及びオータコイド受容体を介した薬物の輸送活性調節
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Papers (101)：
Sun H, Urakami-Takebayashi Y, Motohashi H, Nagai J. Internalization of FITC-albumin in human adipose-derived stem cells: Involvement of clathrin and caveolin. Pharmazie. 2022. 77. 141-146
Miyazaki M, Hayata M, Samukawa N, Iwanaga K, Nagai J. Pharmacokinetic-pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats. Scientific Reports. 2020. 10. 1. 18876
Jin C, Yonezawa A, Yoshimatsu H, Imai S, Koyanagi M, Yamanishi K, Nakagawa S, Itohara K, Omura T, Nakagawa T, et al. Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. Scientific Reports. 2020. 10. 1. 18443
Minori Nakatsuji, Yumiko Urakami-Takebayashi, Sae Miyadokoro, Toyoaki Ikeda, Ikki Takehara, Hongxin Sun, Hideyuki Motohashi, Yoshio Ohno, Junya Nagai. Fatty acids bound to albumin induce prostaglandin E2 production in human renal proximal tubular epithelial cell line HK-2. Biochemical and Biophysical Research Communications. 2020. 530. 1. 273-277
1995 - 1997 Kyoto University Graduate School of Pharmaceutical Sciences
1993 - 1995 Kyoto University Graduate School of Pharmaceutical Sciences
1989 - 1993 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
Ph.D. (Kyoto University)
Work history (8)：
2021/04 - 現在 Osaka Medical and Pharmaceutical University Faculty of Pharmacy Professor
2014/04 - 2021/03 Osaka University of Pharmaceutical Sciences Professor
2012/04 - 2014/03 広島大学大学院医歯薬保健学研究院 准教授
2007/04 - 2012/03 広島大学大学院医歯薬学総合研究科 准教授
2005/04 - 2007/03 広島大学大学院医歯薬学総合研究科 助教授
2002/04 - 2005/03 広島大学大学院医歯薬学総合研究科 助手
2002/06 - 2003/05 デンマーク王国オーフス大学留学 (文部科学省長期在外研究員)
1997/10 - 2002/03 Hiroshima University Institute of Pharmaceutical Sciences, Faculty of Medicine
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Committee career (10)：
2018/04 - 現在 日本薬剤学会代議員
2016/01 - 現在 日本薬物動態学会代議員
2014/04 - 現在 日本薬学会近畿支部委員
2017/02 - 2022/01 日本薬学会代議員
2016/05 - 2018/03 日本薬剤学会評議員
2018 - 2018 平成30年度薬剤学教科担当教員会議 委員長
2010/01 - 2016/12 日本薬物動態学会評議員
2009/04 - 2010/03 平成21年度日本薬学会中国四国支部幹事
2007/04 - 2009/03 日本薬学会ファルマシアトピックス専門小委員
2006/04 - 2008/03 日本薬剤学会将来ビジョン委員
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Awards (3)：
2012/03 - 広島大学 大学院医歯薬学総合研究科教員表彰
2008/10 - 日本薬物動態学会 2008年度DMPK三賞
2005/11 - 日本薬学会中国四国支部 奨励賞
Association Membership(s) (7)：
日本薬学教育学会
, THE MEMBRANE SOCIETY OF JAPAN
, JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
, JAPANESE SOCIETY OF NEPHROLOGY
, THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, THE PHARMACEUTICAL SOCIETY OF JAPAN
