Amano Mutsuki

アマノムツキ | Amano Mutsuki

Affiliation and department：
Job title： Associate professor
Homepage URL (1)： http://www.med.nagoya-u.ac.jp/Yakuri/

Research field (1)： Cell biology

Research theme for competitive and other funds (36)：

2020 - 2023 がん幹細胞のリン酸化シグナルの解析による治療標的分子の探索
2020 - 2023 心臓の硬化を制御するG蛋白質共役受容体の機能解明と心不全治療薬シーズの探索
2019 - 2023 血栓形成における12-リポキシゲナーゼの局在・活性制御メカニズムの解明
2017 - 2021 Analysis of substrate recognition and regulatory mechanisms for protein kinases.
2017 - 2021 Study on regulatory mechanism of neural activity and emotional behavior by intracellular signals

2016 - 2021 Analysis of genes that affect individuality

2017 - 2020 The role of protein kinase N in cardiomyocyte

2015 - 2019 The role of cellular localization of ALOX proteins in vascular aging

2014 - 2017 Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drug

2013 - 2016 Elucidation of phosphorylation signal regulating the cell polarity

2012 - 2015 RhoF promotes murine marginal zone B cell development

2011 - 2015 Involvement of small GTPase Rho family signaling pathways in diseases.

2011 - 2013 Multidimensional analyses of the CDKL5, a causative gene for neurodevelopment disorders, by proteomic and LOF approaches

2008 - 2012 MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

2008 - 2010 Analysis of disease-related genes involved in Rho family small GTPase signaling

2008 - 2009 細胞増殖・分化に関わる蛋白質リン酸化酵素の新規基質スクリーニング法の開発

2006 - 2007 Analysis of disease susceptibility genes on Rho family signaling molecules

2003 - 2007 Molecular mechanism underlying cell polarity and cell migration

2003 - 2007 細胞の極性・遊走を制御する分子機構の解明

2005 - 2006 Rhoキナーゼの新しい展開

2005 - 2006 Effects of statin on vascular diseases-inhibitory mechanism on intimal hyperplasia

2004 - 2005 微小管ダイナミクスと細胞極性・遊走の制御機構

2004 - 2004 細胞間接着及び細胞遊走制御系の解析

2003 - 2003 細胞間接着制御系の網羅的解析

2002 - 2003 Isolation of cell lines with high potentials for lymphatic metastasis from active Rho-Kinase-transfected oral carcinoma and clarification of their machanism of metastasis

2002 - 2002 細胞間接着制御系の網羅的解析

2001 - 2002 Rhoファミリー及びそのエフェクター分子を介する細胞骨格分子の制御機構

2001 - 2001 形態を制御する細胞内骨格制御系の網羅的解析

2000 - 2000 形態を制御する細胞内骨格制御系の網羅的解析

2000 - 2000 CRMP-2による神経軸索・樹状突起の運命決定機構の解明

2000 - 2000 低分子量G蛋白質とその標的蛋白質による血管構築の分子機構

1999 - 2000 低分子量GTP結合蛋白質Rhoを介する細胞骨格の制御機構

1999 - 2000 ANALYSIS OF MOLECULAR MECHANISMS FOR NEURAL NETWOEK FORMATION BY RHO FAMILY

1999 - 2000 Regulation of Cytoskeletons and Cell Adhesions by the Rho Family GTPases.

1999 - 1999 低分子量G蛋白質とその標的蛋白質による血管構築の分子機構

1999 - 1999 蛋白質分解による細胞間接着の制御メカニズムの解析

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Papers (114)：

Yasuhiro Funahashi, Rijwan Uddin Ahammad, Xinjian Zhang, Emran Hossen, Masahiro Kawatani, Shinichi Nakamuta, Akira Yoshimi, Minhua Wu, Huanhuan Wang, Mengya Wu, et al. Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning. Science signaling. 2024. 17. 853. eado9852
Takayuki Kannon, Satoshi Murashige, Tomoki Nishioka, Mutsuki Amano, Yasuhiro Funahashi, Daisuke Tsuboi, Yukie Yamahashi, Taku Nagai, Kozo Kaibuchi, Junichiro Yoshimoto. KANPHOS: Kinase-associated neural phospho-signaling database for data-driven research. Frontiers in Molecular Neuroscience. 2024. 17
Huanhuan Wang, Yukie Yamahashi, Marcel Riedl, Mutsuki Amano, Kozo Kaibuchi. The Evaluation of Rac1 Signaling as a Potential Therapeutic Target of Alzheimer's Disease. International journal of molecular sciences. 2023. 24. 15
Emran Hossen, Yasuhiro Funahashi, Md Omar Faruk, Rijwan Uddin Ahammad, Mutsuki Amano, Kiyofumi Yamada, Kozo Kaibuchi. Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity. International journal of molecular sciences. 2022. 24. 1
Daisuke Tsuboi, Takeshi Otsuka, Takushi Shimomura, Md Omar Faruk, Yukie Yamahashi, Mutsuki Amano, Yasuhiro Funahashi, Keisuke Kuroda, Tomoki Nishioka, Kenta Kobayashi, et al. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior. Cell reports. 2022. 40. 10. 111309-111309

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MISC (24)：

船橋靖広, 吉本潤一郎, 観音隆幸, 西岡朋生, 天野睦紀, 臼井支朗, 貝淵弘三. KANPHOSプラットフォームキナーゼ関連神経リン酸化シグナル伝達に関する包括的データベース(KANPHOS Platform: A comprehensive database for kinase-associated neural phosphorylation signaling). 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [2P-391]
T. Takano, J. Yoshimoto, T. Kannon, T. Nishioka, M. Amano, K. Kaibuchi. KANPHOS (Kinase-Associated Neural PHOspho-Signaling), a comprehensive database for specific substrates of kinases. MOLECULAR BIOLOGY OF THE CELL. 2016. 27
N. Ishizawa, T. Takano, M. Wu, S. Nakamuta, C. Xu, T. Namba, M. Amano, K. Kaibuchi. Long-range Ca2+signaling regulates neuronal polarization via Rho-kinase in a CaMKI-dependent manner. MOLECULAR BIOLOGY OF THE CELL. 2015. 26
Y. Yura, T. Bando, M. Amano, K. Kaibuchi. Novel substrates of Rho kinase in the heart. MOLECULAR BIOLOGY OF THE CELL. 2014. 25
Tomonari Hamaguchi, Kei Kozawa, Katsuhiro Kato, Shohag Md Hasanuzzaman, Xinjian Zhang, Tomoki Nishioka, Mutsuki Amano, Kozo Kaibuchi. Cooperative regulation of cellular contractility by Rho-kinase/Scrib/Shroom2 complex. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 71P-71P

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Work history (3)：

2007/05/01 - 現在 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Associate professor
2003/04/01 - 2007/04/30 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Lecturer
Nagoya University Lecturer

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