Tashiro Kei

タシロケイ | Tashiro Kei

Affiliation and department：
Homepage URL (1)： https://www.kpu-m.ac.jp/doc/classes/igaku/sentan/21.html

Research field (1)： Medical biochemistry

Research keywords (1)：ゲノム医科学

Research theme for competitive and other funds (36)：

2023 - 2026 Investigation of genetic variants and clinical risk factors associated with the progression rate of visual field defect in glaucoma
2021 - 2024 Establishment of multi-omics dataset for elucidating the genetic factors of corneal dystrophy
2021 - 2024 Establishing a Risk Prediction Method for Primary Open Angle Glaucoma Using Next Generation Sequencer and Analysis on Non-synonymous Valiant
2020 - 2023 Identification and kinetic analysis of glaucoma resistance gene with primary open angle glaucoma
2020 - 2023 遺伝解析の統計的検出力を高めるための緑内障臨床情報クラスタリング手法の開発

2020 - 2023 疾患関連ゲノム領域に潜む人種差から迫る緑内障発症機序解明に向けたマルチオミクス

2017 - 2021 Evaluation of genetic factors for deterioration of primary open angle glaucoma

2017 - 2020 Identification of variants associated with intraocular pressure lowering efficacy of glaucoma eye drops by genome-wide association study

2017 - 2020 Identification of responsible genomic region of Primary Open Angle Glaucoma with International Consortium

2014 - 2017 Revealing pathogenesis of Fuchs endothelial corneal dystrophy in Japanese by means of exome array

2014 - 2017 Genome wide association study by visual field defect pattern in primary open angle glaucoma

2014 - 2017 Identifying novel angiogenesis-related pathway from differentially expressed genes during retinal development obtained by the microarray analysis

2012 - 2015 Candidate gene analysis of well-known genes in primary open-angle glaucoma patients utilizing custom-made gene chip

2011 - 2013 Identification of Japanese-specific SNP in exfoliation glaucoma patients with genome-wide association analysis of 1000K microarray

2011 - 2013 The analysis of the role of SFRP2 function in immune system

2011 - 2012 Gain more insight, perform the following genome-wide association studies in Japanese, counterargument to the study that need correct re-diagnosis by Europe-an study

2010 - 2012 Pioneering Research to Elucidate the Pathogenic Mechanism and Genetic Susceptibility of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis

2009 - 2011 Investigation of epigenetic factors in the pathogenesis of glucocorticoid-induced glaucoma

2009 - 2011 Elucidation of the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilage

2007 - 2008 SDF-1 plays a role in bone growth and repair by cytoskeleton modulation

2007 - 2008 Developmental research for a New Therapy for SJS/TEN

2005 - 2006 Clarification of the roles of SDF-1 on mesenchymal stem cells in bone graft healing-toward a clinical application for the improvement of allograft healing-

2005 - 2006 Research on underlying mechanisms of Stevens-Johnson syndrome

2004 - 2004 幹細胞生存支持活性があり増殖活性は無いサイトカインSDNSFによる生体防御の解析

2004 - 2004 サイトカインSDNSFの放射線治療における幹細胞生存支持能のマウスモデルでの解析

2003 - 2004 Analysis of molecular mechanisms of inner ear development by characterizing a secreted molecule, OC29, isolated from rat otocyst.

2001 - 2002 Isolation and characterization of stem cell-derived neural stem/progenitor cell supporting factor, SDNSF.

2001 - 2001 SDF13'A遺伝子多型のエイズ制御機序の後天的バイアスをふまえた解析

2001 - 2001 新たなHIV-1ウイルス感染標的細胞としてのヒト脳由来神経系幹細胞の解析

2000 - 2000 ヒト脳由来神経系幹細胞株の分化誘導系によるHIVウイルス標的細胞の同定

1999 - 2000 Analysis of novel proteins produced by vascular tissues and their clinical application

1999 - 1999 サルにおけるSDF-1発現系の作製と新たなCXCR4アンタゴニストの探索

1998 - 1999 Virus Receptors and Cytokines

1998 - 1998 SDF-1遺伝子の遺伝子多型とエイズ発症時期の相関及びそのメカニズム

1997 - 1998 The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

1997 - 1997 SDF1発現アデノウイルスによるエイズ遺伝子治療法開発と、SDF1の諸作用の検討.

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Papers (117)：

Yasuo Takashima, Tohru Inaba, Tasuku Matsuyama, Kengo Yoshii, Masami Tanaka, Kazumichi Matsumoto, Kazuki Sudo, Yuichi Tokuda, Natsue Omi, Masakazu Nakano, et al. Potential marker subset of blood-circulating cytokines on hematopoietic progenitor-to-Th1 pathway in COVID-19. Frontiers in Medicine. 2024. 11
Yuka Kawaji-Kanayama, Taku Tsukamoto, Masakazu Nakano, Yuichi Tokuda, Hiroaki Nagata, Kentaro Mizuhara, Yoko Katsuragawa-Taminishi, Reiko Isa, Takahiro Fujino, Yayoi Matsumura-Kimoto, et al. miR-17-92 cluster-BTG2 axis regulates B-cell receptor signaling in mantle cell lymphoma. Cancer science. 2023
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, et al. 7,8-Dihydroxy-3-(4′-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells. Biochemical and Biophysical Research Communications. 2023. 638. 200-209
Tatsuya Nakagawa, Yuichi Tokuda, Masakazu Nakano, Yuya Komori, Naoya Hanada, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Kei Tashiro, Noriko Koizumi, et al. RNA-Seq-Based Transcriptome Analysis of Corneal Endothelial Cells Derived from Patients with Fuchs Endothelial Corneal Dystrophy. 2022
Hiroaki Oku, Akihide Watanabe, Yuichi Tokuda, Tomomichi Nakayama, Kei Tashiro, Chie Sotozono, Masakazu Nakano. Efficient DNA/RNA extraction from tarsal plates by SK mill, a freeze-crush apparatus. Journal of biochemistry. 2022. 172. 6. 385-394

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MISC (97)：

徳田雄市, 奥拓明, 中山知倫, 渡辺彰英, 外園千恵, 田代啓, 中野正和. Optimization of nucleic acid extraction methods from tissues for obtaining high-quality genomic analysis data. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
Yoko Ikeda, Kazuhiko Mori, Morio Ueno, Kengo Yoshii, Masakazu Nakano, Yuko Maruyama, Kojiro Imai, Natsue Omi, Hiroki Mieno, Ryuichi Sato, et al. Seasonal Variation of Intraocular Pressure in Non-Glaucomatous Subjects. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022. 63. 7
徳田雄市, 中野正和, 田代啓. Next-Generation Sequencer and Cancer Genomic Medicine. 京都府立医科大学雑誌. 2022. 131. 4
奥拓明, 渡辺彰英, 米田亜規子, 中山知倫, 徳田雄市, 中野正和, 田代啓, 外園千恵. ヒト眼瞼脂腺癌組織からの核酸の抽出方法の検討. 日本眼瞼義眼床手術学会プログラム・抄録集. 2022. 33rd (CD-ROM)
Yoko Ikeda, Kazuhiko Mori, Morio Ueno, Kengo Yoshii, Masakazu Nakano, Eyuichi Sato, Natsue Omi, Yuko Maruyama, Fumiko Sato, Kojiro Imai, et al. Trend of continuous intraocular pressure decrease over a 20-year period in Japanese normal tension glaucoma patients. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2021. 62. 8

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Association Membership(s) (3)：

THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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