Rchr
J-GLOBAL ID：200901039420217830   Update date: Jun. 03, 2025

Kaji Hirokazu

カジ ヒロカズ | Kaji Hirokazu
Affiliation and department：
Institute of Science Tokyo Laboratory for Biomaterials and Bioengineering (LBB), Institute of Integrated Research (IIR)

About Institute of Science Tokyo Laboratory for Biomaterials and Bioengineering (LBB), Institute of Integrated Research (IIR)


Job title： Professor
Other affiliations (3)：
  • Institute of Science Tokyo  Research Center for Autonomous Systems Materialogy (ASMat), Institute of Integrated Research (IIR)   Professor
  • Institute of Science Tokyo  Graduate School of Medical and Dental Sciences   Professor
  • HPS Inc.  Co-founder & CTO
Homepage URL  (1)： https://www.tmd.ac.jp/bmc
Research field  (5)： Nanobioscience ,  Nanomaterials ,  Biomaterials ,  Biomedical engineering ,  Nano/micro-systems
Research keywords  (6)： Biointerface ,  Biomaterial ,  Biodevices ,  Cell and Tissue Engineering ,  Microfluidics ,  Drug delivery
Research theme for competitive and other funds  (22)：
  • 2024 - 2030 Creation of immune-instructive drug delivery devices
  • 2024 - 2026 口腔内ディスバイオーシスと全身疾患の統合的理解に向けたin vitro評価システムの創出
  • 2023 - 2026 Creation of in vitro evaluation systems for integrated understanding of oral dysbiosis and systemic diseases
  • 2022 - 2024 Preparation of organoids with human placental structure and construction of placental barrier ability evaluation system
  • 2021 - 2024 妊娠高血圧症候群の発症機序の解明に向けたヒト栄養膜細胞の血管浸潤モデルの開発
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Papers (208)：
  • Toshiaki Abe, Reiko Daigaku, Xie Yuting, Yasukazu Daigaku, Nobuhiro Nagai, Hirokazu Kaji, Aya Katsuyama, Yuki Katsukura, Yasuko Izumida, Atsuko Suzuki, et al. Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1. Investigative ophthalmology & visual science. 2025. 66. 4. 70-70
  • Takeshi HORI, Hirokazu KAJI. Alternatives to animal testing for assessing transplacental transfer. Translational and Regulatory Sciences. 2025
  • Inês M Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima, Serge Ostrovidov, Takeshi Hori, Yuji Nashimoto, Hirokazu Kaji. Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta. Lab on a chip. 2024
  • 梨本 裕司, 今野 杏, 西川 香里, 伊野 浩介, 堀 武志, 梶 弘和, 新宅 博文, 後藤 昌史, 珠玖 仁. 膵臓移植・膵島移植・人工膵臓の現状と展望 生体模倣システムによる膵島の血管形成能力と遺伝子発現の照合. 膵臓. 2024. 39. 3. A279-A279
  • 梨本 裕司, 今野 杏, 西川 香里, 伊野 浩介, 堀 武志, 梶 弘和, 新宅 博文, 後藤 昌史, 珠玖 仁. 膵臓移植・膵島移植・人工膵臓の現状と展望 生体模倣システムによる膵島の血管形成能力と遺伝子発現の照合. 膵臓. 2024. 39. 3. A279-A279
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MISC (167)：
  • XU Jiacheng, 堀武志, 梨本裕司, 吉田昭太郎, 梶弘和. Chitosan Micro-Mesh Sheets for Sustainable Production of Cultured Fish Fillets. 化学とマイクロ・ナノシステム. 2024. 23. 2
  • 清水聖晟, 稲垣舞, 堀武志, 梶弘和, 岡江寛明, 有馬隆博, 立川正憲. 脳微小血管内皮細胞におけるヒト栄養膜幹細胞由来細胞外小胞の取り込み機構. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2024. 45th
  • 緑川凜, 堀武志, 野口幸希, 西村友宏, 西村友宏, 梶弘和, 登美斉俊. ヒト栄養膜幹細胞から分化させた合胞体栄養膜細胞におけるpropionic acid輸送機構. 日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集. 2024. 42nd-32nd
  • 梨本裕司, 今野杏, 西川香里, 伊野浩介, 堀武志, 梶弘和, 新宅博文, 新宅博文, 後藤昌史, 珠玖仁. 生体模倣システムによる膵島の血管形成能力と遺伝子発現の照合. 膵臓(Web). 2024. 39. 3
  • 稲垣皓介, 堀武志, 梨本裕司, 吉田昭太郎, 梶弘和. 2層型マイクロ流体デバイスを用いたヒト網膜関門モデルの構築. 化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM). 2024. 49th
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Patents (6)：
  • 細胞担持パターン化ナノ薄膜
  • タンパク質および細胞が内壁に固定された中空構造体
  • 持続性ドラッグデリバリーシステム
  • 角膜経上皮電気抵抗値の測定方法
  • 細胞または組織の培養制御装置とその方法
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Books (14)：
  • Microfluidic Cell Culture Systems, 2nd Edition
    Elsevier Publishing 2019
  • 臓器チップの技術と開発動向
    シーエムシー出版 2018
  • Retinal Degenerative Diseases, Advances in Experimental Medicine and Biology, vol 854.
    Springer 2016
  • Stem Cell Biology and Tissue Engineering in Dental Sciences
    Elsevier Publishing 2015
  • Retinal Degenerative Diseases, Advances in Experimental Medicine and Biology, vol 801.
    Springer 2014
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Lectures and oral presentations  (87)：
  • Development of a multilayered drug-delivery sheet that allows minimally invasive delivery to the eye
    (EMBS Micro and Nanotechnology in Medicine Conference 2018)
  • Microfluidic cell culture model of the outer-blood-retina-barrier
    (EMBS Micro and Nanotechnology in Medicine Conference 2018)
  • Development of an implantable cell culture device for retinal diseases
    (EMBS Micro and Nanotechnology in Medicine Conference 2018)
  • Development of a human corneal model using a blinking eyelid device
    (EMBS Micro and Nanotechnology in Medicine Conference 2018)
  • Microfluidic model of the outer blood-retina-barrier
    (MicroTAS 2018 2018)
ｍore...
Education (3)：
  • 2003 - 2005 Tohoku University Graduate School of Engineering Department of Bioengineering and Robotics
  • 2001 - 2003 Tohoku University Graduate School of Engineering Department of Biomolecular Engineering
  • 1997 - 2001 Tohoku University School of Engineering Department of Molecular Chemistry and Engineering
Professional career (1)：
  • Ph.D. (Tohoku University)
Work history (14)：
  • 2025/06 - 現在 Institute of Science Tokyo Graduate School of Medical and Dental Sciences Professor
  • 2024/10 - 現在 Institute of Science Tokyo Research Center for Autonomous Systems Materialogy (ASMat), Institute of Integrated Research (IIR) Professor
  • 2024/10 - 現在 Institute of Science Tokyo Laboratory for Biomaterials and Bioengineering (LBB), Institute of Integrated Research (IIR) Professor
  • 2023/10 - 現在 HPS Inc. Co-founder & CTO
  • 2023/04 - 現在 Keio University Faculty of Pharmacy, Graduate School of Pharmaceutical Sciences Visiting Professor
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Committee career (38)：
  • 2022/05 - 現在 Society for Chemistry and Micro-Nano Systems Director
  • 2018/04 - 現在 The Japanese Society for Biomaterials Councillor
  • 2011/01 - 現在 Journal of Biomaterials and Tissue Engineering Associate Editor
  • 2022 - 2024 PRiME2024 PRiME2024実行委員会幹事委員
  • 2023/07 - IEEE EMBC’23 Conference Editorial Board Reviewer
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Awards (16)：
  • 2022/12 - 公益財団法人カシオ科学振興財団 研究助成(特別テーマ)
  • 2019/12 - 一般財団法人青葉工学振興会 青葉工学振興会賞
  • 2018/05 - 公益財団法人インテリジェント・コスモス学術振興財団 インテリジェント・コスモス奨励賞
  • 2018/03 - 公益財団法人テルモ生命科学芸術財団 テルモ生命科学芸術財団研究開発助成
  • 2016/04 - 化学とマイクロ・ナノシステム学会 化学とマイクロ・ナノシステム学会奨励賞
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Association Membership(s) (11)：
The Association for Research in Vision and Ophthalmology ,  Japanese Society of Biorheology ,  The Japan Society of Mechanical Engieers ,  The Electrochemical Society of Japan ,  日本動物実験代替法学会 ,  Japanese Society for Medical and Biological Engineering ,  Society For Biomaterials ,  Biomedical Engineering Society ,  Society for Chemistry and Micro-Nano Systems ,  The Japan Society of Drug Delivery System ,  Japanese Society for Biomaterials
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