J-GLOBAL ID:200901039469189564   Update date: Jan. 10, 2020

Ochiai Kuniyasu

オチアイ クニヤス | Ochiai Kuniyasu
Affiliation and department:
Job title: Professor
Research field  (4): Biomolecular chemistry ,  Pathological medical chemistry ,  Bacteriology (including mycology) ,  Morphological basic dentistry
Research keywords  (18): Oral microbiology ,  Periodontitis ,  Periodontopathic bacteria ,  Short-chain fatty acids ,  Butyric acid ,  自然免疫 ,  epigenetic effects ,  bactarial metabolite ,  Oral bacteria ,  Immunorespose ,  Periodontal siseases ,  Periodontopathic bacteria ,  Systemic infection ,  HIV ,  短鎖脂肪酸 ,  酪酸 ,  エピジェネティク作用 ,  バイオフィルム
Papers (118):
  • Kobayashi Y, Hayashi M, Yoshino F, Tamura M, Yoshida A, Ibi H, Lee MC, Ochiai K, Ogiso B. Passive ultrasonic irrigation in the presence of a low concentration of hydrogen peroxide enhances hydroxyl radical generation and bactericidal effect against Enterococcus faecalis. J Oral Sci, 56(1), 35-9. 2014. 56. 1. 35-39
  • Cueno ME, Kamio N, Imai K, Ohya M, Tamura M, Ochiai K. Structural Significance of the β1K396 Residue Found in the Porphyromonas gingivalis Sialidase β-Propeller Domain: A Computational Study with Implications for Novel Therapeutics Against Periodontal Disease. OMICS. 2014. 18. 9. 591-599
  • Cueno ME, Tamura M, Ohya M, Ochiai K. Similar physiological effects in Porphyromonas gingivalis ATCC 33277 under hemin-excess and hemin-limited concentrations are putatively associated to different hydrogen peroxide function. Anaerobe. 2014. 28. 178-181
  • Kamio N, Imai K, Shimizu K, Cueno ME, Tamura M, Saito Y, Ochiai K. Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir. Cell Mol Life Sci. 2014
  • Imai K, Kamio N, Cueno ME, Saito Y, Inoue H, Saito I, Ochiai K. Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epsteinn-Barr virus latency in B95-8 cells. FEBS J, 281(9), 2148-58. 2014. 281. 9. 2148-2158
MISC (28):
  • Cueno ME, Tamura M, Ochiai K. Middle-aged rats orally supplemented with gel- encapsulated catechin favorably increases blood cytosolic NADPH levels. Phytomedicine. 2015. 22. (4). 425-430
  • Arai T, Ochiai K, Senpuku H. Actinomyces naeslundii GroEL-dependent initial attachment and biofilm formation in a flow cell system. J MIcrobiol Methods,. 2015. 109. 160-166
  • Cueno ME, Nagano K, Imai K, Tamura M, Yoshimura F, Ochiai K. Ab initio modeling approach towards establishing the structure and docking orientation of the Porphyromonas gingivalis FimA. J Mol Graph Model. 2015. 55. 65-71
  • Cueno ME, Kamio N, Seki K, Kurita-Ochiai T, Ochiai K. High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells. Cell Stress Chaperones. 2015. 20. (4). 709-713
  • Kato A, Imai K, Ochiai K, Ogata Y. Prevalence and quantitative analysis of Epstein - Barr virus DNA and Porphyromonas gingivalis associated with Japanese chronic periodontitis patients. Clin Oral Invest. 2015. 19. (7). 1605-1610
Books (18):
  • Use of mutans in the elucidation of virulence of Streptococcus mutans.
    Secretory immunity and infection. 1978
  • Innate host factors and microbial studies using rat secreations:
    Animal Models in Cariology 1981
  • Effects of periodontopathic bacteria in secondary immunoresponse and isotype switching.
    Frontiers of mucosal immunology 1991
  • 分子生物学歯科小辞典
    口腔保健協会 2003
  • 嫌気性菌代謝産物・脂肪酸の為害作用:線維芽細胞アポトーシス誘導
    消化器と免疫 2003
Lectures and oral presentations  (276):
  • 嫌気性代謝産物・酪酸誘導T細胞アポトーシス回避機構に於ける接着分子の役割
    (日本細菌学会総会 2004)
  • 炎症性サイトカインの歯周病原性細菌増殖促進作用
    (歯科基礎医学会 2004)
  • Characterization of effects of butyric acid on cell proliferation, cell cycle distribution and apoptosis.
    (日本免疫学会総会 2004)
  • Fibroblasts rescure butyric acid-induced T-cell apoptosis: Rple of adhesion molecules
    (国際歯科研究学会日本部会 2004)
  • Effects of SCFA on mucous membrane and immunoresponse
    (Science Research Symposium; Frontiers of GI Research 2004)
Education (1):
  • - 1973 Nihon University Faculty of Veterinary Medicine Veterinary medicine
Work history (5):
  • 1973/04 - 1974/03 日本大学松戸歯科大学(現松戸歯学部)副手
  • 1975/04 - 1987/03 日本大学松戸歯科大学(現松戸歯学部)助手
  • 1987/04 - 2000/03 日本大学講師
  • 2000/04 - 2005/03 明海大学教授(歯学部)
  • 2005/04 - 日本大学教授(歯学部)
Association Membership(s) (8):
International Association for Dental Research ,  日本無菌生物ノートバイオロジー学会 ,  日本消化器免疫学会 ,  日本歯周病学会 ,  腸内細菌学会 ,  日本免疫学会 ,  歯科基礎医学会 ,  日本細菌学会
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