Rchr
J-GLOBAL ID：200901039583660196   Update date: Feb. 01, 2024

Ogawa Tomohisa

オガワ トモヒサ | Ogawa Tomohisa
Affiliation and department：
Tohoku University

About Tohoku University


Homepage URL  (1)： https://www.agri.tohoku.ac.jp/enzyme/index-j.html
Research field  (5)： Genomics ,  Biochemistry ,  Structural biochemistry ,  Molecular biology ,  Applied biochemistry
Research keywords  (8)： Venomics ,  snake venom ,  biominerarization ,  lectin ,  genome ,  molecular evolution ,  protein engineering ,  protein
Research theme for competitive and other funds  (34)：
  • 2004 - 現在 Molecular Mechanism of Bio-mineralization and Its Development to The Novel Nano-Technology
  • 1996 - 現在 Study on the structure and function relationship of snake venom proteins and their inhibitor
  • 1996 - 現在 Study on the stucture and function relationship of lectins
  • 1989 - 現在 Molecular diversification of protein structures and functions via accelerated evolution
  • 2018 - 2022 Trans-omic study for diversity and evolution of venomic proteins of Protobothrops flavoviridis.
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Papers (177)：
  • Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa. A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site. Toxins. 2023. 15. 8. 500-500
  • Ryota Suzuki, Haruka Takahashi, Chika Yoshida, Masafumi Hidaka, Tomohisa Ogawa, Eugene Futai. Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production. International Journal of Molecular Sciences. 2023. 24. 4. 3970-3970
  • Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela J. Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, et al. A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nature Communications. 2022. 13. 1
  • Akiko Isomoto, Eiichi Shoguchi, Kanako Hisata, Jun Inoue, Yinrui Sun, Kenji Inaba, Noriyuki Satoh, Tomohisa Ogawa, Hiroki Shibata. Active Expression of Genes for Protein Modification Enzymes in Habu Venom Glands. Toxins. 2022
  • Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, et al. Hidden pathway for cytokine receptor activation: a marine sponge-derived lectin reveals sugar-mediated thrombopoietin receptor activation. 2022
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MISC (377)：
  • 浅野航佑, 原口大輝, 須藤愛莉咲, 松井崇, 松井崇, 小寺義男, 小寺義男, 小川智久, 横山武司, 田中良和. ストップコドンリードスルーの分子機構解明. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
  • 影山大夢, 小野寺かこ, 松井崇, 松井崇, 小川智久, 小川智久, 横山武司, 田中良和. Crystal Structure Analysis and Sugar Binding Analysis of a Novel Lectin Like Protein. Photon Factory News. 2022. 39. 4
  • 渡辺ひかり, 吉田知加, 蔡哲夫, 日高將文, 小川智久, 富田泰輔, 二井勇人. Functional analysis of γ-secretase subunit Aph1 in the yeast reconstitution system. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 関正義, 小川智久, 日高將文, 二井勇人. Construction of expression and purification system in yeast for analysis of γ-secretase mutant. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 小川智久, 大泉結帆, 平垣内一子, 田中良和, 村本光二. Identification of converting factors for anti-cancer peptide lunasin from soybean isolated and their mechanism. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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Patents (10)：
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Books (15)：
  • Common sense of chemical substances you need to know
    SB Creative 2016 ISBN:9784797356892
  • 知っていると安心できる成分表示の知識 その食品、その洗剤、本当に安全なの?
    SBcreative 2016 ISBN:9784797356908
  • 話したくなる!つかえる生物
    明日香出版社 2014 ISBN:9784756917126
  • Lectin Methods and Protocols Part4, Method in Molecular Biology: Tracing Ancestral Specificity of Lectins: Ancestral Sequence Reconstruction Method as a New Approach in Protein Engineering
    Humana Press 2014
  • Protein Engineering -Technology and Application: Experimental molecular archeology: reconstruction of ancestral mutants and evolutionary history of proteins as a new approach in protein engineering.
    InTech 2013
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Lectures and oral presentations  (32)：
  • 動物毒は,どのように進化してきたのか?
    (第42回日本分子生物学会大会 ワークショップ 『毒生物が産生する『トキシン』の織りなす多元的世界』(3AW-03) 2019)
  • Venomics project reveals the evolution and molecular mechanism to produce highly divergent venom proteins.
    (International Conference on Flow Dynamics (ICFD) OS8: Advanced Physical Stimuli and Biological Responses 2018)
  • The habu snake venomics reveals accelerated evolution and an extensive alternative splicing to produce highly divergent venom proteins
    (5thCWRU-Tohoku Joint Workshop. 2018)
  • Advanced research of unique venom-related animals based on Venomics project: Overview and introduction
    (第89回日本生化学会大会シンポジウム:2S07ベノミクス研究による‘おもしろ’毒関連生物の生化学研究の新展開 2016)
  • 祖先型タンパク質再構築法によりタンパク質の機能・進化を探る
    (フォーラム「生命科学談話シリーズ:アミノ酸・ペプチド・タンパク質の新世代バイオケミストリ」(ペプチド科学九州フォーラム) 2016)
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Education (2)：
  • - 1991 Kyushu University Graduate School of Science, Department of Chemistry
  • - 1986 Kyushu University Faculty of Science 化学
Professional career (1)：
  • 博士(理学) (Kyushu University)
Work history (11)：
  • 2022/04 - 現在 Tohoku University Graduate School of Agricultural Science, Division of Biochemistry, Laboratory of Enzymology Professor
  • 2020/04 - 2022/03 Tohoku University Graduate School of Agricultural Science
  • 2001/04 - 2020/03 Graduate School of Life Sciences, Tohoku University associate professor
  • 2007/04 - 2009/03 Center for Interdisciplinary Research, Tohoku University Associate professor Project Leader
  • 2004/10 - 2007/03 Center for Interdisciplinary Research, Tohoku University Associate professor Leader
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Committee career (3)：
  • 2007/04 - 現在 東北糖鎖研究会 世話人
  • 2005/07 - 2008/07 毒素シンポジウム 運営委員
  • 2005/04 - 2007/03 日本農芸化学会 東北支部会計幹事
Awards (2)：
  • 2004/09/19 - 日本農芸化学会東北支部 日本農芸化学会東北支部支部奨励賞(第2回) 「加速進化によるタンパク質の構造と機能の多様化」
  • 1994/02/03 - 財団法人 井上科学振興財団 Inoue Research Award for Young Scientists (10th) ハブ毒腺ホスホリパーゼA2アイソザイムのcDNAクローニング及び構造解析:非翻訳領域配列の異常に高い保存性
Association Membership(s) (9)：
アメリカ生化学・分子生物学会 ,  JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY ,  International Society on Toxinology ,  日本動物細胞工学会 ,  日本分子生物学会 ,  日本糖質学会 ,  日本化学会 ,  日本農芸化学会 ,  日本生化学会
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