Rchr
J-GLOBAL ID：200901039583660196   Update date: Sep. 24, 2024

Ogawa Tomohisa

オガワ トモヒサ | Ogawa Tomohisa
Affiliation and department：
Tohoku University

About Tohoku University


Homepage URL  (1)： https://www.agri.tohoku.ac.jp/enzyme/index-j.html
Research field  (5)： Genomics ,  Biochemistry ,  Structural biochemistry ,  Molecular biology ,  Applied biochemistry
Research keywords  (8)： Venomics ,  snake venom ,  biominerarization ,  lectin ,  genome ,  molecular evolution ,  protein engineering ,  protein
Research theme for competitive and other funds  (34)：
  • 2004 - 現在 Molecular Mechanism of Bio-mineralization and Its Development to The Novel Nano-Technology
  • 1996 - 現在 Study on the structure and function relationship of snake venom proteins and their inhibitor
  • 1996 - 現在 Study on the stucture and function relationship of lectins
  • 1989 - 現在 Molecular diversification of protein structures and functions via accelerated evolution
  • 2018 - 2022 Trans-omic study for diversity and evolution of venomic proteins of Protobothrops flavoviridis.
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Papers (178)：
  • Zhengguang Wang, Zhihan Yang, Mami Shishido, Khadija Daoudi, Masafumi Hidaka, Hiroaki Tateno, Eugene Futai, Tomohisa Ogawa. Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction. International journal of molecular sciences. 2024. 25. 12
  • Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa. A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site. Toxins. 2023. 15. 8. 500-500
  • Ryota Suzuki, Haruka Takahashi, Chika Yoshida, Masafumi Hidaka, Tomohisa Ogawa, Eugene Futai. Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production. International Journal of Molecular Sciences. 2023. 24. 4. 3970-3970
  • Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela J. Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, et al. A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nature Communications. 2022. 13. 1
  • Akiko Isomoto, Eiichi Shoguchi, Kanako Hisata, Jun Inoue, Yinrui Sun, Kenji Inaba, Noriyuki Satoh, Tomohisa Ogawa, Hiroki Shibata. Active Expression of Genes for Protein Modification Enzymes in Habu Venom Glands. Toxins. 2022
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MISC (399)：
  • 小川智久, 榊原里奈, 川崎創, 日高將文, 二井勇人. ヘビ毒成分はアルツハイマー病治療薬の候補となりうるか?. トキシンシンポジウム予稿集. 2023. 69th
  • 伊藤匠, 日高將文, 小川智久, 二井勇人. 出芽酵母を用いたC9orf72連鎖性筋萎縮性側索硬化症および前頭側頭型認知症におけるAUG非依存性翻訳機構解析系の構築. 日本生化学会大会(Web). 2023. 96th
  • 鈴木優香, 日高將文, 二井勇人, 小川智久. Phosphorylation of 26 kDa matrix protein regulates bio-mineralization in pearl shell. 日本生化学会大会(Web). 2023. 96th
  • 宍戸茉美, 小川紗也加, 日高將文, 二井勇人, 小川智久, 小川智久. Brevibacillus expression system is efficient for producing Dioscorea batatas mannose binding lectin DB1. 日本生化学会大会(Web). 2023. 96th
  • 山口晶也, 鈴木涼太, 日高將文, 小川智久, 二井勇人. Specific presenilin mutation near the substrate binding site modulate γ-secretase activity. 日本生化学会大会(Web). 2023. 96th
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Patents (10)：
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Books (15)：
  • Common sense of chemical substances you need to know
    SB Creative 2016 ISBN:9784797356892
  • 知っていると安心できる成分表示の知識 その食品、その洗剤、本当に安全なの?
    SBcreative 2016 ISBN:9784797356908
  • 話したくなる!つかえる生物
    明日香出版社 2014 ISBN:9784756917126
  • Lectin Methods and Protocols Part4, Method in Molecular Biology: Tracing Ancestral Specificity of Lectins: Ancestral Sequence Reconstruction Method as a New Approach in Protein Engineering
    Humana Press 2014
  • Protein Engineering -Technology and Application: Experimental molecular archeology: reconstruction of ancestral mutants and evolutionary history of proteins as a new approach in protein engineering.
    InTech 2013
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Lectures and oral presentations  (32)：
  • 動物毒は,どのように進化してきたのか?
    (第42回日本分子生物学会大会 ワークショップ 『毒生物が産生する『トキシン』の織りなす多元的世界』(3AW-03) 2019)
  • Venomics project reveals the evolution and molecular mechanism to produce highly divergent venom proteins.
    (International Conference on Flow Dynamics (ICFD) OS8: Advanced Physical Stimuli and Biological Responses 2018)
  • The habu snake venomics reveals accelerated evolution and an extensive alternative splicing to produce highly divergent venom proteins
    (5thCWRU-Tohoku Joint Workshop. 2018)
  • Advanced research of unique venom-related animals based on Venomics project: Overview and introduction
    (第89回日本生化学会大会シンポジウム:2S07ベノミクス研究による‘おもしろ’毒関連生物の生化学研究の新展開 2016)
  • 祖先型タンパク質再構築法によりタンパク質の機能・進化を探る
    (フォーラム「生命科学談話シリーズ:アミノ酸・ペプチド・タンパク質の新世代バイオケミストリ」(ペプチド科学九州フォーラム) 2016)
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Education (2)：
  • - 1991 Kyushu University Graduate School of Science, Department of Chemistry
  • - 1986 Kyushu University Faculty of Science 化学
Professional career (1)：
  • 博士(理学) (Kyushu University)
Work history (11)：
  • 2022/04 - 現在 Tohoku University Graduate School of Agricultural Science, Division of Biochemistry, Laboratory of Enzymology Professor
  • 2020/04 - 2022/03 Tohoku University Graduate School of Agricultural Science
  • 2001/04 - 2020/03 Graduate School of Life Sciences, Tohoku University associate professor
  • 2007/04 - 2009/03 Center for Interdisciplinary Research, Tohoku University Associate professor Project Leader
  • 2004/10 - 2007/03 Center for Interdisciplinary Research, Tohoku University Associate professor Leader
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Committee career (3)：
  • 2007/04 - 現在 東北糖鎖研究会 世話人
  • 2005/07 - 2008/07 毒素シンポジウム 運営委員
  • 2005/04 - 2007/03 日本農芸化学会 東北支部会計幹事
Awards (2)：
  • 2004/09/19 - 日本農芸化学会東北支部 日本農芸化学会東北支部支部奨励賞(第2回) 「加速進化によるタンパク質の構造と機能の多様化」
  • 1994/02/03 - 財団法人 井上科学振興財団 Inoue Research Award for Young Scientists (10th) ハブ毒腺ホスホリパーゼA2アイソザイムのcDNAクローニング及び構造解析:非翻訳領域配列の異常に高い保存性
Association Membership(s) (9)：
アメリカ生化学・分子生物学会 ,  JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY ,  International Society on Toxinology ,  日本動物細胞工学会 ,  日本分子生物学会 ,  日本糖質学会 ,  日本化学会 ,  日本農芸化学会 ,  日本生化学会
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