Rchr
J-GLOBAL ID：200901039880850816
Update date: Nov. 11, 2024
Inoue Katsuhisa
イノウエ カツヒサ | Inoue Katsuhisa
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://www.ps.toyaku.ac.jp/yakubutsudotai/
Research field (2)：
Clinical pharmacy
, Physiology
Research keywords (7)：
pharmaceutics
, drug-drug interaction
, pharmacokinetics
, membrane permeability
, intestinal absorption
, drug disposition
, transporter
Research theme for competitive and other funds (22)：
- 2021 - 2024 Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.
- 2021 - 2024 消化管の薬物吸収を制御する新規促進拡散型オリゴペプチドトランスポーターの分子同定
- 2021 - 2024 Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract
- 2020 - 2024 Studies searching for urate-lowering food components using pharmacokinetic model of urate in the whole body
- 2018 - 2021 配糖体の体内動態を制御する促進拡散型トランスポーターの同定
- 2016 - 2020 Studies searching for functional food components to control novel SUA regulators
- 2015 - 2018 Conformationally restricted polyamines: Solid-phase synthesis and biological evaluation
- 2014 - 2017 Elucidation of the molecular mechanism of unstirred water layer
- 2015 - 2017 Development of a drug delivery system targeting activated neutrophils
- 2012 - 2014 Physiological role of a novel nucleobase transporter in the utilization of extracellular purine nucleobases
- 2011 - 2012 Functional Characteristics of a Novel Transporter Specifically Expressed in the Endoplasmic Reticulum in Dendritic Cells and its Role in Immune System
- 2010 - 2011 Species-specific transport systems for nucleobases and urate in small intestine.
- 2008 - 2010 Regulation of intestinal expression of proton-coupled folate transporter and its relevance to folate malabsorption in alcohol consumption.
- 2008 - 2010 Identification and Functional Analysis of the Na^+-Dependent Glycerol Transporter in HCT-15 Cells
- 2008 - 2009 Functional characterization of folate transport in osteoclast
- 2006 - 2007 Effect of Probiotics on the absorption of drugs from the Small Intestine
- 2006 - 2007 Molecular and Functional Characteristics of Glycerol Transporter in HCT-15 Cell Model
- 2006 - 2007 腎臓の有機カチオン/プロトン交換輸送系を担う機能性分子の同定
- 2004 - 2006 小腸特異的な新規コレステロールトランスポーターの機能解析
- 2004 - 2005 Novel Transporter Responsible for Intestinal Glycerol Absorption : Characterization of Its Function and Physiological Role
- 2003 - Study on the drug transport in intestine
- 2000 - 2002 Pharmacokinetic and Cellular Biological Study on Colonic Absorption : Strategies for Optimized Controlled Release Oral Drug Delivery
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Papers (101)：
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Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, Hiroaki Yuasa. SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption. eLife. 2024. 13
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Miyuki Takemura, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka. Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 72-78
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Koki Sugiyama, Hiroe Shimano, Masaki Takahashi, Yuta Shimura, Asuka Shimura, Takahito Furuya, Ryuto Tomabechi, Yoshiyuki Shirasaka, Kei Higuchi, Hisanao Kishimoto, et al. The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells. Journal of Pharmaceutical Sciences. 2023
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Keisuke Kiyomiya, Ryuto Tomabechi, Naoki Saito, Kenta Watai, Tappei Takada, Yoshiyuki Shirasaka, Hisanao Kishimoto, Kei Higuchi, Katsuhisa Inoue. Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy. Molecular Pharmaceutics. 2023
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Yuta Funai, Kazuki Ichijo, Satoru Suzuki, Yuta Tateishi, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka. Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats. Scientific Reports. 2023. 13. 1
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MISC (72)：
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岸本久直, 井上勝央. 薬物の腸管吸収過程における粘液層の寄与とその分子機構解明を目指して. ファルマシア. 2020. 56. 4. 325-329
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黒澤俊樹, 手賀悠真, 山口朋子, 川端健二, 望月達貴, 井上勝央, 楠原洋之, 出口芳春. Analysis of 6-mercaptopurine transport mechanism across blood-brain barrier model derived from human iPS cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
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苫米地隆人, 志村可奈恵, 飯田奏子, 浜田圭佑, 岸本久直, 岸本久直, 白坂善之, 白坂善之, 田口晃弘, 野水基義, et al. Peptide transporters enhance the readthrough activity of a negamycin derivative TCP-112. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
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黒澤俊樹, 手賀悠真, 山口朋子, 川端健二, 望月達貴, 井上勝央, 楠原洋之, 出口芳春. ヒトiPS細胞由来脳毛細血管内皮細胞における6-mercaptopurineの輸送機構解析. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2019. 41st
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井上勝央, 湯浅博昭. 核酸塩基トランスポーターSLC43A3/ENBT1の輸送特性とガンシクロビルを用いた自殺遺伝子療法における役割. 医学のあゆみ. 2019. 271. 1
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Education (3)：
- 1996 - 1998 Kumamoto University Graduate School of Pharmaceutical Sciences
- 1994 - 1996 Kumamoto University Graduate School of Pharmaceutical Sciences
- 1990 - 1994 Kumamoto University Faculty of Pharmaceutical Science
Professional career (1)：
- Ph.D. (Kumamoto University)
Work history (5)：
- 2013/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Professor
- 2007/10 - 2013/03 Nagoya City University Graduate School of Pharmaceutical Sciences Associate Professor
- 2001/02 - 2007/09 Nagoya City University Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences Lecturer
- 2001/06 - 2003/05 Medical College of Georgia Department of Biochemistry and Molecular Biology Postdoctoral Researcher
- 1998/12 - 2001/01 Nagoya City University Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences Assistant Professor
Committee career (8)：
- 2023/11 - 現在 The Japanese Society for the Study of Xenobiotics Director
- 2021/04 - 現在 Editorial Board, Biological and Pharmaceutical Bulletin (BPB)/Chemical and Pharmaceutical Bulletin (CPB)
- 2017/04 - 現在 Drug Metabolism and Pharmacokinetics Editorial Advisory Board
- 2017/01 - 現在 Journal of Pharmaceutical Sciences Editorial Advisory Board
- 2016/05 - 現在 The Academy of Pharmaceutical Science and Technology, Japan Councilor
- 2016/01 - 現在 日本薬物動態学会 トランスポーターDIS 委員長
- 2014 - 現在 Japan Transporter Research Association Advisor
- 2011/11 - 現在 The Japanese Society for the Study of Xenobiotics Councilor
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Awards (1)：
- 2011/11 - The Japanese Society for the Study of Xenobiotics Award for Young Scientists
Association Membership(s) (3)：
日本薬学会
, 日本薬剤学会
, 日本薬物動態学会
