Nonoguchi Hiroshi

2011 - 2012 The Investigation of the Mechanisms of the Regulation of RAS by Vasopresin V1a Receptor

2010 - 2011 The Investigation of the Mechanisms of the Regulation of RAS by Vasopresin V1a Receptor

2009 - 2011 Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins

2009 - 2011 The role of vasopressin V1a receptor in diabetic nephropathy and the invention of new therapy.

2007 - 2008 The investigation of the role of interaction of two types of antidiuretic hormone receptors for diuresis and the invention of the new therapy for renal edema.

2005 - 2008 Strategy for protection of kidney injury based on functioal relation betwee renal specific stress response mechanisms and xenobiotic detoxication systems

2006 - 2007 糖尿病性腎症の糸球体上皮細胞(足細胞)障害におけるGSK-3Βの役割の検討

2005 - 2006 Functional analysis of antidiuretic hormone receptor using V1a knockout mice and invention of new diuretics.

2004 - 2005 The role of GSK-3 dependent transcriptional factor on glomerulo injury

2003 - 2004 The investigation of the mechanisms and therapy of the abnormality in antidiuretic hormone action in patients with chronic renal failure

2001 - 2002 The effect of interstitial osmolarity in juxta-glomerular apparatus on macula densa cells and cloning of mammalian osmosensor

2001 - 2002 Regulation of diuresis by 2 types of antidiuretic hormone receptor in chronic renal failure and therapeutic investigation of edema

1999 - 2000 Role of renal arginase in acute renal failure

1999 - 2000 プロスタシンの増殖作用の研究および早期腫瘍マーカーとしての有用性の研究

1998 - 2000 Regulation of NO synthesis by the urea cycle enzymes

1998 - 1999 The study on molecular biological mechanisms and therapy of sodiam and acid disturbance in renal failure

1997 - 1998 Prevention of acute renal failure by anti-endothelin converting enzyme.

1997 - 1998 Role of endothelin converting enzyme in essential hypertension

1997 - 1997 新しいGTP結合蛋白(G_<13>)をかいしたイオンチャネル活性機序の解明

1996 - 1997 Gene therapy for acute renal failure

1996 - 1997 The investigation of molecular biological mechanisms and therapy of refractory renal edema.

1994 - 1995 The investigation of the mechanisms and the rapy of renal edema from the acpect of cell porality.

1993 - 1995 Elucidation of the mechanism of essential hypertension making a transgenic mice made by putative kallikrein binding protein

1992 - 1994 Elucidation of mechanism of acute renal failure by use molecular biological techniques

1992 - 1993 Role and therapy of renal medullary dysfunction as a risk factor for chronic renal failure

1990 - 1990 体液調節における心房性ナトリウム利尿ホルモンの役割(特に尿細管作用について)