Yanagi Yusuke

ヤナギユウスケ | Yanagi Yusuke

Affiliation and department：
Job title： Professor Emeritus

Research field (1)： Virology

Research keywords (13)：微生物 , モルビリウイルス , パラミクソウイルス , 麻疹ウイルス , 免疫抑制 , ウイルスレセプター , 感染 , ウイルス , Negative strand RNA virus , Paramyxovirus , Measles virus , Virus Receptor , Virology

Research theme for competitive and other funds (26)：

2020 - 2023 Measles virus transmission in the brain
2017 - 2019 Molecular basis of the mumps virus tropism to glandular and nervous tissues
2017 - 2019 パラミクソウイルスのシアル酸受容体の多様性と宿主との共進化
2012 - 2017 Interplay between viruses and their host cells
2012 - 2017 Molecular basis of host cell competency in virus infection

2012 - 2014 Study of pathogenesis for SSPE caused by measles virus infection and development of the antiviral drug

2009 - 2012 Measles pathogenesis as studied using animal models

2006 - 2011 Matrix of Infection Phenomena

2006 - 2010 Infection and pathogenesis of negative strand RNA viruses

2005 - 2008 Analysis of measles pathogenesis using the mouse model expressing measles virus receptor SLAM and recombinant viruses

2001 - 2006 Molecular Bases underlying Microbial Infections and the Host Responses

2005 - 2005 感染現象の研究マトリックスを構築するための企画調査研究

2001 - 2005 Measles virus receptors and the pathogenesis of measles

2003 - 2004 INTERACTION BETWEEN MEASLES VIRUS AND INNATE IMMUNITY

2003 - 2003 RNAウイルス研究の新展開

2001 - 2002 Tropism and pathogenesis of measles virus

2001 - 2002 デングウイルスの細胞侵入機構の研究

1998 - 2000 Identification of the cellular receptor for measles virus

1997 - 1997 膵癌切除後のAdjuvant Cytokine Gene Therapy-ハムスター膵管癌を用いた基礎的研究-

1997 - 1997 C型肝炎ウイルスの細胞レセプター解明へのアプローチ

1996 - 1997 Cellular receptor for measles virtus

1994 - 1995 Molecular mechanism of measles virus-induced immunosuppression

1992 - 1993 ANALYSIS OF FUNCTIONAL PROPERTIES OF VIRAL

1985 - 1988 On the origin and adaptive changes of genetic restriction molecules on T cells

1987 - 1987 野生遺伝子の導入による生物機能モデル動物の開発

1986 - 1987 T cell antigen receptor and chain genes and MHC restriction

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Papers (148)：

Yuichi Hirai, Ryuichi Takemoto, Yusuke Yanagi, Yuta Shirogane. Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering. Journal of Virology. 2025. e0230724
Jiei Sasaki, Akihiko Sato, Michihito Sasaki, Iori Okabe, Kota Kodama, Satoko Otsuguro, Kosuke Yasuda, Hirotatsu Kojima, Yasuko Orba, Hirofumi Sawa, et al. X-206 exhibits broad-spectrum anti-β-coronavirus activity, covering SARS-CoV-2 variants and drug-resistant isolates. Antiviral Research. 2024. 106039-106039
Ryuichi Takemoto, Yuichi Hirai, Shumpei Watanabe, Hidetaka Harada, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane. Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein. Journal of Virology. 2023. 97. 5
Yuta Shirogane, Hidetaka Harada, Yuichi Hirai, Ryuichi Takemoto, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi. Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus. Science Advances. 2023. 9. 4. eadf3731
Ryuichi Takemoto, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane. Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin. Journal of Virology. 2022. 96. 3. e0194921

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MISC (2)：

鈴木干城, 柳雄介, 橋口隆生. 膜融合トリガー型ヘマグルチニンストークの構造解析から考察されるモルビリウイルスの膜融合活性化メカニズム. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
橋口隆生, 柳雄介, 前仲勝実. 【ウイルス学・構造生物学】結晶構造が解き明かす麻疹ウイルスワクチン成功の理由. メディカルバイオ. 2008. 5. 1. 10-11

Education (1)：

- 1980 Kyushu University School of Medicine

Professional career (1)：

(BLANK) (The University of Tokyo)

Work history (13)：

2021/04 - 現在 Kyushu University Professor Emeritus
2022/04 - 2024/03 Nagasaki University
2021/08 - 2022/03 Nagasaki University
2021/04 - 2021/07 Nagasaki University
2000/04 - 2021/03 Kyushu University Faculty of Medical Sciences

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Committee career (3)：

2021/05 - 2024 日本微生物学連盟常務理事
2015/04 - 2021/04 日本微生物学連盟理事長
2010/01 - 2013/12 日本ウイルス学会理事長

Awards (3)：

2006 - 野口英世記念医学賞
1996 - Fellow of the American Association for the Advancement of Science
1995 - 日本ウイルス学会杉浦奨励賞

Association Membership(s) (2)：

日本ウイルス学会 , American Association for the Advancement of Science

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