Hayakawa Morisada

ハヤカワモリサダ | Hayakawa Morisada

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://www.jichi.ac.jp/medicine/about/department/basic/biochemistry/pathophysiology/index.html , http://www.jichi.ac.jp/biochem/byotai/index.html

Research field (5)： Nutrition and health science , Hematology and oncology , Immunology , Pathobiochemistry , Molecular biology

Research keywords (6)： NAFLD , Hemophilia , Allergy , サイトカイン , 喘息 , ゲノム編集

Research theme for competitive and other funds (11)：

2024 - 2027 肝類洞血流障害を起点としたNASH病態形成機構の解明
2021 - 2024 血漿糖タンパク質VWFによる非アルコール性脂肪肝炎(NASH)発症機序の解明
2020 - 2023 Neuro-immune linkage in ST2-transgenic mouse
2018 - 2021 Elucidation of the origin of blood coagulation factor VIII-producing cells for the development of new hemophilia treatment
2018 - 2021 NAFLDに対する新規治療ターゲットとしてのIL-33/ST2Lシグナルの役割

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Papers (43)：

Takafumi Hiramoto, Hiroshi Inaba, Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Hiroshi Nishimasu, Osamu Nureki, Ei Kinai, Tsukasa Ohmori. Genome editing of patient-derived iPSCs identifies a deep intronic variant causing aberrant splicing in hemophilia A. Blood advances. 2023. 7. 22. 7017-7027
Yuji Kashiwakura, Kazuhiro Endo, Atsushi Ugajin, Tomohiro Kikuchi, Shuji Hishikawa, Hitoyasu Nakamura, Yuko Katakai, Nemekhbayar Baatartsogt, Takafumi Hiramoto, Morisada Hayakawa, et al. Efficient Gene Transduction in Pigs and Macaques with the Engineered AAV Vector AAV.GT5 for Hemophilia B Gene Therapy. Molecular Therapy - Methods & Clinical Development. 2023. 30. 502-514
冨樫朋貴, ネメフバヤル・バータルツォグト, 長尾恭光, 柏倉裕志, 早川盛禎, 鴨下信彦, 平本貴史, 藤原隆行, 森下英理子, 濡木理, et al. 改変型プロテインCによるプロテインC欠損マウスのゲノム編集治療. 日本血栓止血学会誌. 2023. 34. 2. 257-257
柏倉裕志, 遠藤和洋, 宇賀神敦, 菊地智博, 菱川修司, 中村仁康, 片貝祐子, Nemekhbayar Baatartsogt, 平本貴史, 早川盛禎, et al. 血友病B遺伝子治療に対する新規改変型AAV.GT5ベクターの応用. 日本血栓止血学会誌. 2023. 34. 2. 240-240
冨樫朋貴, ネメフバヤル・バータルツォグト, 長尾恭光, 柏倉裕志, 早川盛禎, 鴨下信彦, 平本貴史, 藤原隆行, 森下英理子, 濡木理, et al. 改変型プロテインCによるプロテインC欠損マウスのゲノム編集治療. 日本血栓止血学会誌. 2023. 34. 2. 257-257

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MISC (20)：

早川盛禎, 尾崎裕美, 大森司. IκBζはマスト細胞からのIL-33依存性サイトカイン・ケモカイン産生を増強する. 臨床免疫・アレルギー科. 2021. 75. 355-362
早川盛禎. IL-33デコイ受容体による皮膚炎症の制御. コスメトロジー研究報告. 2015. 23. 93-97
早川盛禎. 生物系薬学制御性T細胞の発生を制御する腸内細菌代謝産物. ファルマシア. 2014. 50. 8. 815-815
HAYAKAWA Hiroko, HAYAKAWA Morisada, OHTO-OZAKI Hiromi. Soluble ST2 controls allergic inflammation in a murine model of asthma. FASEB JOURNAL. 2013. 27. 835.4
早川盛禎. IL-33(Interleukin-33). 日本生化学会会誌. 2011. 83. 253

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Lectures and oral presentations (82)：

Correction of human hemophilia B gene in iPSCs by base-editing based on engineered Cas9
(2020)
Factor VIII expression in vivo
(2020)
Increase in the Treatment Efficiency of Genome Editing for Hemophilia B by Codon-Optimization of SaCas9 in Mice.
(ISTH2020, Virtual Congress 2020)
Correction of Human Hemophilia B Gene in iPSCs by Base-Editing Approach Based on Engineered Cas9 with Broad PAM Flexibility
(ISTH2020, Virtual Congress 2020)
塩基編集による血友病B患者由来iPSCの遺伝子修復
(第42回日本血栓止血学会学術総会 2020)

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Education (3)：

- 2000 Jichi Medical University
- 1995 Japan Advanced Institute of Science and Technology
- 1993 Nihon University

Professional career (1)：

Ph. D. (Jichi Medical University)

Work history (7)：

2024/11 - 現在 Jichi Medical University School of Medicine, Graduate School of Medicine, Center for Gene Therapy Research Associate Professor
2018/11 - 2024/10 Jichi Medical University School of Medicine, Graduate School of Medicine, Center for Gene Therapy Research Assistant Professor
2011/01 - 2018/10 Jichi Medical University School of Medicine, Graduate School of Medicine Assistant Professor
2009/01 - 2011/01 Harvard Medical School Massachusetts General Hospital, Cutaneous Biology Research Center Research Fellow
2006/11 - 2009/01 Jichi Medical University School of Medicine, Graduate School of Medicine Assistant Professor

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Committee career (3)：

2012/04 - 現在日本生化学会関東支部栃木県
2017/11 - 2021/10 日本生化学会代議員
2012/10 - 2013/09 日本生化学会代議員

Awards (4)：

2024/06 - 国際血栓止血学会 2024 ISTH Best Poster Award
2011/11 - 武田科学振興財団医学系研究奨励受賞
2008/11 - 自治医科大学自治医科大学優秀論文賞
1998/04 - 自治医科大学自治医科大学大学院研究奨励賞

Association Membership(s) (8)：

International Society for Advancement of Cytometry , Japanese Society of Hematology , アメリカ生化学・分子生物学会 , 日本分子生物学会 , 日本生化学会 , American Society for Biochemistry and Molecular Biology , The Japanese Biochemical Society , The Molecular Biology Society of Japan

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